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Changing the face of neuroimaging research: Comparing a new MRI de-facing technique with popular alternatives
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In: Neuroimage (2021)
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Longitudinal anatomic, functional, and molecular characterization of Pick disease phenotypes
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In: Neurology (2020)
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Differential DNA methylation of vocal and facial anatomy genes in modern humans
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Reducing Racial/Ethnic Disparities in Mental Health Service Use among Emerging Adults: Community-Level Supply Factors
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In: Ethn Health (2020)
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Group-based parenting interventions to promote child development in rural Kenya: a multi-arm, cluster-randomised community effectiveness trial
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In: Lancet Glob Health (2020)
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Lifestyle-Related Exposure to Cadmium and Lead is Associated with Diabetic Kidney Disease
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In: J Clin Med (2020)
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Language recovery following stroke
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In: Clin Neuropsychol (2019)
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The influence of β-amyloid on [(18)F]AV-1451 in semantic variant of primary progressive aphasia
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Cognitive Predictors of Sentence Comprehension in Children with and without Developmental Language Disorder: Implications for Assessment and Treatment
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In: Int J Speech Lang Pathol (2019)
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Missed Opportunities When Communicating With Limited English-Proficient Patients During End-of-Life Conversations: Insights From Spanish-Speaking and Chinese-Speaking Medical Interpreters
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In: J Pain Symptom Manage (2019)
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[18F]AV-1451 tau-PET and primary progressive aphasia
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Josephs, Keith A.; Martin, Peter R.; Botha, Hugo; Schwarz, Christopher G.; Duffy, Joseph R.; Clark, Heather M.; Machulda, Mary M.; Graff-Radford, Jonathan; Weigand, Stephen D.; Senjem, Matthew L.; Utianski, Rene L.; Drubach, Daniel A.; Boeve, Bradley F.; Jones, David T.; Knopman, David S.; Petersen, Ronald C.; Jack, Clifford R.; Lowe, Val J.; Whitwell, Jennifer L.. - 2018
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Abstract:
OBJECTIVES: To assess [(18)F]AV-1451 tau-PET uptake patterns across the primary progressive aphasia (PPA) variants (logopenic, semantic and agrammatic), examine regional uptake patterns of [(18)F]AV-1451 independent of clinical diagnosis, and compare the diagnostic utility of [(18)F]AV-1451, [(18)F]-fluorodeoxygluclose (FDG)-PET and MRI to differentiate the PPA variants. METHODS: We performed statistical parametric mapping of [(18)F]AV-1451 across 40 PPA patients (logopenic-PPA=14, semantic-PPA=13 and agrammatic-PPA=13) compared to 80 cognitively normal, PiB-negative controls, age and gender matched 2:1. Principal component analysis of regional [(18)F]AV-1451 tau-PET SUVR was performed to understand underlying patterns of [(18)F]AV-1451 uptake independent of clinical diagnosis. Penalized multinomial regression analyses were utilized to assess diagnostic utility. RESULTS: Logopenic-PPA showed striking uptake throughout neocortex, particularly temporoparietal, compared to controls, semantic-PPA and agrammatic-PPA. Semantic-PPA and agrammatic-PPA showed milder patterns of focal [(18)F]AV-1451 uptake. Semantic-PPA showed elevated uptake (left>right) in anteromedial temporal lobes, compared to controls and agrammatic-PPA. Agrammatic-PPA showed elevated uptake (left>right) throughout prefrontal white matter and in subcortical grey matter structures, compared to controls and semantic-PPA. The principal component analysis of regional [(18)F]AV-1451 indicated two primary dimensions, a severity dimension that distinguished logopenic-PPA from agrammatic-PPA and semantic-PPA, and a frontal-versus-temporal contrast that distinguishes agrammatic-PPA and semantic-PPA cases. Diagnostic utility of [(18)F]AV-1451was superior to MRI and at least equal to FDG-PET. INTERPRETATION: [(18)F]AV-1451binding characteristics differ across the PPA variants, and were excellent at distinguishing between the variants. [(18)F]AV-1451binding characteristics were as good or better than other brain imaging modalities utilized in clinical practice, suggesting that [(18)F]AV-1451 may have clinical diagnostic utility in PPA.
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Keyword:
Article
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896771/
http://www.ncbi.nlm.nih.gov/pubmed/29451323
https://doi.org/10.1002/ana.25183
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| 12 |
Tau Uptake in Agrammatic Primary Progressive Aphasia with and without Apraxia of Speech
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Tau-PET imaging with [18F]AV-1451 in Primary Progressive Apraxia of Speech
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Prosodic and Phonetic Subtypes of Primary Progressive Apraxia of Speech
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Neuropsychological analysis of auditory verbal hallucinations
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Development of a Culturally Informed Child Safety Curriculum for American Indian Families
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Linguistic Validation of Interactive Educational Interventions in NeuroTrauma
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Tracking the Development of Agrammatic Aphasia: a Tensor-Based Morphometry Study
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Factors Linking Childhood Experiences to Adult Romantic Relationships among African Americans
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