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1
Living with Family Is Directly Associated with Regular Dental Checkup and Indirectly Associated with Gingival Status among Japanese University Students: A 3-Year Cohort Study
In: Int J Environ Res Public Health (2021)
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2
Evaluation of Social Cognition Measures for Japanese Patients with Schizophrenia Using an Expert Panel and Modified Delphi Method
In: J Pers Med (2021)
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3
Optimizing in-hospital triage for large vessel occlusion using a novel clinical scale (GAI(2)AA)
Ohta, Tsuyoshi; Nakahara, Ichiro; Matsumoto, Shoji. - : Lippincott Williams & Wilkins, 2019
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4
Mu rhythm suppression reflects mother-child face-to-face interactions: a pilot study with simultaneous MEG recording
Hasegawa, Chiaki; Ikeda, Takashi; Yoshimura, Yuko. - : Nature Publishing Group, 2016
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5
Apc-Mutant Kyoto Apc Delta (KAD) Rats Are Susceptible to 4-NQO-Induced Tongue Carcinogenesis
Abstract: Despite widening interest in the possible association between infection/inflammation and cancer development, knowledge of this issue in relation to oral cancer remains inadequate. This study aimed to determine the susceptibility of Apc-mutant Kyoto Apc Delta (KAD) rats, which are vulnerable to developing inflammation-associated colorectal carcinogenesis, to 4-nitroquinoline 1-oxide (4-NQO)-induced tongue carcinogenesis in order to clarify the role of inflammation in oral cancer. KAD (20 males and 22 females) and F344/NS1c (22 males and 23 females) rats received drinking water with or without 4-NQO (20 ppm) for eight weeks. Histopathological and immunohistochemical analyses of the tongue were performed at week 20. Additionally, the mRNA expression of inflammatory cytokines in the tongue mucosa was determined at week 8. Tongue squamous cell carcinoma (SCC) developed in the KAD and F344/NS1c rats that received 4-NQO. Regardless of gender, the incidence and multiplicity of tongue SCC were greater in the KAD rats than in the F344/NS1c rats. In addition, the multiplicity of tongue SCC in the female KAD rats was significantly greater than that observed in the male KAD (p < 0.01) and female F344/NS1c rats (p < 0.05). The levels of inflammation and the mRNA expression of inflammatory cytokines in the tongue in the 4-NQO-treated female KAD rats were the highest among the rats given 4-NQO. These results show that KAD rats, particularly females, are susceptible to 4-NQO-induced tongue carcinogenesis, suggesting the utility of models employing KAD rats for investigating the pathobiology of oral (tongue) carcinogenesis associated with inflammation.
Keyword: Article
URL: http://www.ncbi.nlm.nih.gov/pubmed/25050571
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190553
https://doi.org/10.3390/cancers6031522
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6
Anterior Commissure Involvement in Humanherpes Virus 6 Encephalitis
Fujii, Katsunori; Ikehara, Hajime; Nagasawa, Koo. - : SAGE Publications, 2014
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7
Semantic distribution study of noun-noun compounds in the Japanese CT clinical reports
Nishimoto, Naoki; Terae, Satoshi; Jiang, Guoqian. - : American Medical Informatics Association, 2006
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