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1
Semantic activation in Parkinson's disease patients on and off levodopa
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Hemispheric contributions to semantic activation: A divided visual field and event-related potential investigation of time-course.
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3
Dopaminergic neuromodulation of semantic processing: A 4-T fMRI study with levodopa
Abstract: There is emerging evidence that alterations in dopaminergic transmission can influence semantic processing, yet the neural mechanisms involved are unknown. The influence of levodopa (L-DOPA) on semantic priming was investigated in healthy individuals (n = 20) using event-related functional magnetic resonance imaging with a randomized, double-blind crossover design. Critical prime-target pairs consisted of a lexical ambiguity prime and 1) a target related to the dominant meaning of the prime (e.g., bank-money), 2) a target related to the subordinate meaning (e.g., fence-sword), or 3) an unrelated target (e.g., ball-desk). Behavioral data showed that both dominant and subordinate meanings were primed on placebo. In contrast, there was preserved priming of dominant meanings and no significant priming of subordinate meanings on L-DOPA, the latter associated with decreased anterior cingulate and dorsal prefrontal cortex activity. Dominant meaning activation on L-DOPA was associated with increased activity in the left rolandic operculum and left middle temporal gyrus. These findings suggest that L-DOPA enhances frequency-based semantic focus via prefrontal and temporal modulation of automatic semantic priming and through engagement of anterior cingulate mechanisms supporting attentional/controlled priming.
Keyword: 170101 Biological Psychology (Neuropsychology; 170204 Linguistic Processes (incl. Speech Production and Comprehension); Activation; Ambiguous Words; Brain Activity; Brain imaging; C1; cognitive function; Cortex; Dopamine; Event-related Fmri; fMRI; Functional Mri; Language; Lexical ambiguity; Modulation; Parkinsons-disease; Physiological Psychology); Psychopharmacology; Semantic priming; Working-memory
URL: https://espace.library.uq.edu.au/view/UQ:189707
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4
Verbal fluency, semantics, context and symptom complexes in schizophrenia
Vogel, Adam P.; Chenery, Helen J.; Dart, Catriona M.. - : Springer New York LLC, 2009
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5
Impaired semantic inhibition during lexical ambiguity repetition in parkinson's disease
Copland, David A.; Sefe, Gameli; Ashley, Jane. - : Elsevier Masson, 2009
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6
The basal ganglia circuits, dopamine, and ambiguous word processing: A neurobiological account of priming studies in Parkinson's disease
Chenery, Helen J.; Angwin, Anthony J.; Copland, David A.. - : Cambridge University Press, 2008
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7
Transdermal nicotine modulates strategy-based attentional semantic processing in non-smokers
Holmes, Anna D.; Chenery, Helen J.; Copland, David A.. - : Cambridge University Press, 2008
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8
Neural correlates of semantic priming for ambiguous words: An event-related fMRI study
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9
The speed of lexical activation is altered in Parkinson's disease
Angwin, Anthony J.; Chenery, Helen J.; Copland, David A.. - : Taylor & Francis Inc, 2007
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10
Self-paced reading and sentence comprehension in Parkinson's disease
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11
Summation of semantic priming and complex sentence comprehension in Parkinson's disease
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12
Hemispheric contributions to lexical ambiguity resolution: Evidence from individuals with complex language impairment following left-hemisphere lesions
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13
Discourse priming of homophones in individuals with dominant subcortical lesions, cortical lesions, and Parkinson’s disease
Copland, David A.; Chenery, Helen J.; Murdoch, Bruce E.. - : Psychology Press, 2001
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