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Neurodevelopmental outcomes among extremely premature infants with linear growth restriction.
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Comparing two facets of emotion perception across multiple neurodegenerative diseases.
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In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020)
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| 3 |
Comparing two facets of emotion perception across multiple neurodegenerative diseases.
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In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020)
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Chunking and redintegration in verbal short-term memory. ...
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| 6 |
Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia.
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In: Alzheimer disease and associated disorders, vol 33, iss 3 (2019)
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| 7 |
Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia.
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In: Alzheimer disease and associated disorders, vol 33, iss 3 (2019)
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| 8 |
Neurodevelopmental outcomes among extremely premature infants with linear growth restriction.
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In: Journal of perinatology : official journal of the California Perinatal Association, vol 39, iss 2 (2019)
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| 9 |
Assessing and mapping language, attention and executive multidimensional deficits in stroke aphasia. ...
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| 10 |
Assessing and mapping language, attention and executive multidimensional deficits in stroke aphasia.
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Abstract:
There is growing awareness that aphasia following a stroke can include deficits in other cognitive functions and that these are predictive of certain aspects of language function, recovery and rehabilitation. However, data on attentional and executive (dys)functions in individuals with stroke aphasia are still scarce and the relationship to underlying lesions is rarely explored. Accordingly in this investigation, an extensive selection of standardized non-verbal neuropsychological tests was administered to 38 individuals with chronic post-stroke aphasia, in addition to detailed language testing and MRI. To establish the core components underlying the variable patients' performance, behavioural data were explored with rotated principal component analyses, first separately for the non-verbal and language tests, then in a combined analysis including all tests. Three orthogonal components for the non-verbal tests were extracted, which were interpreted as shift-update, inhibit-generate and speed. Three components were also extracted for the language tests, representing phonology, semantics and speech quanta. Individual continuous scores on each component were then included in a voxel-based correlational methodology analysis, yielding significant clusters for all components. The shift-update component was associated with a posterior left temporo-occipital and bilateral medial parietal cluster, the inhibit-generate component was mainly associated with left frontal and bilateral medial frontal regions, and the speed component with several small right-sided fronto-parieto-occipital clusters. Two complementary multivariate brain-behaviour mapping methods were also used, which showed converging results. Together the results suggest that a range of brain regions are involved in attention and executive functioning, and that these non-language domains play a role in the abilities of patients with chronic aphasia. In conclusion, our findings confirm and extend our understanding of the multidimensionality of stroke aphasia, emphasize the importance of assessing non-verbal cognition in this patient group and provide directions for future research and clinical practice. We also briefly compare and discuss univariate and multivariate methods for brain-behaviour mapping.
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Keyword:
80 and over; Aged; Aphasia; Attention; Brain; Brain Mapping; Cognition; Comprehension; Computer-Assisted; Executive Function; Female; Humans; Image Processing; Language; Language Tests; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Principal Component Analysis; Semantics; Speech; Stroke
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URL: https://doi.org/10.17863/CAM.42398
https://www.repository.cam.ac.uk/handle/1810/295344
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| 11 |
Language lateralisation measured across linguistic and national boundaries.
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In: Cortex; a journal devoted to the study of the nervous system and behavior, vol. 111, pp. 134-147 (2019)
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| 12 |
Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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In: JAMA neurology, vol 75, iss 3 (2018)
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| 13 |
Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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In: JAMA neurology, vol 75, iss 3 (2018)
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Cognitive Working Memory Training (CWMT) in adolescents suffering from Attention-Deficit/Hyperactivity Disorder (ADHD): A controlled trial taking into account concomitant medication effects.
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In: Psychiatry research, vol. 269, pp. 79-85 (2018)
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A neural network underlying intentional emotional facial expression in neurodegenerative disease.
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A neural network underlying intentional emotional facial expression in neurodegenerative disease.
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| 18 |
Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration.
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In: Brain and behavior, vol 7, iss 4 (2017)
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| 19 |
Observing conversational laughter in frontotemporal dementia.
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In: Journal of neurology, neurosurgery, and psychiatry, vol 88, iss 5 (2017)
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| 20 |
Observing conversational laughter in frontotemporal dementia.
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In: Journal of neurology, neurosurgery, and psychiatry, vol 88, iss 5 (2017)
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