| 1 |
The trans-ancestral genomic architecture of glycemic traits.
|
|
|
|
In: Nature genetics, vol. 53, no. 6, pp. 840-860 (2021)
|
|
BASE
|
|
Show details
|
|
|
| 2 |
Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.
|
|
|
|
In: Molecular psychiatry, vol 25, iss 10 (2020)
|
|
BASE
|
|
Show details
|
|
|
| 3 |
Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.
|
|
|
|
In: Molecular psychiatry, vol 25, iss 10 (2020)
|
|
BASE
|
|
Show details
|
|
|
| 4 |
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.
|
|
|
|
In: Nature genetics, vol 50, iss 7 (2018)
|
|
BASE
|
|
Show details
|
|
|
| 5 |
Global genetic differentiation of complex traits shaped by natural selection in humans.
|
|
|
|
In: Nature communications, vol. 9, no. 1, pp. 1865 (2018)
|
|
BASE
|
|
Show details
|
|
|
| 6 |
GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.
|
|
Trampush, JW; Yang, MLZ; Yu, J; Knowles, E; Davies, G; Liewald, DC; Starr, JM; Djurovic, S; Melle, I; Sundet, K; Christoforou, A; Reinvang, I; DeRosse, P; Lundervold, AJ; Steen, VM; Espeseth, T; Räikkönen, K; Widen, E; Palotie, A; Eriksson, JG; Giegling, I; Konte, B; Roussos, P; Giakoumaki, S; Burdick, KE; Payton, A; Ollier, W; Horan, M; Chiba-Falek, O; Attix, DK; Need, AC; Cirulli, ET; Voineskos, AN; Stefanis, NC; Avramopoulos, D; Hatzimanolis, A; Arking, DE; Smyrnis, N; Bilder, RM; Freimer, NA; Cannon, TD; London, E; Poldrack, RA; Sabb, FW; Congdon, E; Conley, ED; Scult, MA; Dickinson, D; Straub, RE; Donohoe, G; Morris, D; Corvin, A; Gill, M; Hariri, AR; Weinberger, DR; Pendleton, N; Bitsios, P; Rujescu, D; Lahti, J; Le Hellard, S; Keller, MC; Andreassen, OA; Deary, IJ; Glahn, DC; Malhotra, AK; Lencz, T
|
|
In: Molecular psychiatry, vol 22, iss 3 (2017)
|
|
Abstract:
The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these barriers, the current study utilized GWAS meta-analysis to examine the association of common genetic variation (~8M single-nucleotide polymorphisms (SNP) with minor allele frequency ⩾1%) to general cognitive function in a sample of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Consortium (COGENT). In addition, we utilized individual SNP lookups and polygenic score analyses to identify genetic overlap with other relevant neurobehavioral phenotypes. Our primary GWAS meta-analysis identified two novel SNP loci (top SNPs: rs76114856 in the CENPO gene on chromosome 2 and rs6669072 near LOC105378853 on chromosome 1) associated with cognitive performance at the genome-wide significance level (P<5 × 10-8). Gene-based analysis identified an additional three Bonferroni-corrected significant loci at chromosomes 17q21.31, 17p13.1 and 1p13.3. Altogether, common variation across the genome resulted in a conservatively estimated SNP heritability of 21.5% (s.e.=0.01%) for general cognitive function. Integration with prior GWAS of cognitive performance and educational attainment yielded several additional significant loci. Finally, we found robust polygenic correlations between cognitive performance and educational attainment, several psychiatric disorders, birth length/weight and smoking behavior, as well as a novel genetic association to the personality trait of openness. These data provide new insight into the genetics of neurocognitive function with relevance to understanding the pathophysiology of neuropsychiatric illness.
|
|
Keyword:
Adult; Alleles; Biological Sciences; Cognition; European Continental Ancestry Group; Female; Gene Frequency; Genetic Association Studies; Genetic Loci; Genetic Predisposition to Disease; Genetic Variation; Genome-Wide Association Study; Humans; Male; Medical and Health Sciences; Middle Aged; Multifactorial Inheritance; Neurocognitive Disorders; Polymorphism; Psychiatry; Psychology and Cognitive Sciences; Single Nucleotide
|
|
URL: https://escholarship.org/uc/item/2qj7x9fw
|
|
BASE
|
|
Hide details
|
|
|
| 7 |
Functional annotation signatures of disease susceptibility loci improve SNP association analysis.
|
|
|
|
BASE
|
|
Show details
|
|
|
| 8 |
Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment.
|
|
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2014)
|
|
BASE
|
|
Show details
|
|
|
| 9 |
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci
|
|
|
|
BASE
|
|
Show details
|
|
|
| 10 |
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
|
|
|
|
In: PLoS genetics, vol 7, iss 7 (2011)
|
|
BASE
|
|
Show details
|
|
|
| 11 |
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
|
|
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2009)
|
|
BASE
|
|
Show details
|
|
|
|
|
