| 1 |
Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
|
|
|
|
BASE
|
|
Show details
|
|
|
| 2 |
Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
|
|
|
|
BASE
|
|
Show details
|
|
|
| 3 |
Factors that predict diagnostic stability in neurodegenerative dementia.
|
|
|
|
In: Journal of neurology, vol 266, iss 8 (2019)
|
|
BASE
|
|
Show details
|
|
|
| 4 |
Factors that predict diagnostic stability in neurodegenerative dementia.
|
|
|
|
In: Journal of neurology, vol 266, iss 8 (2019)
|
|
BASE
|
|
Show details
|
|
|
| 5 |
Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia.
|
|
|
|
In: Alzheimer disease and associated disorders, vol 33, iss 3 (2019)
|
|
BASE
|
|
Show details
|
|
|
| 6 |
Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
|
|
|
|
BASE
|
|
Show details
|
|
|
| 7 |
Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia.
|
|
|
|
In: Alzheimer disease and associated disorders, vol 33, iss 3 (2019)
|
|
BASE
|
|
Show details
|
|
|
| 8 |
Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
|
|
|
|
BASE
|
|
Show details
|
|
|
| 9 |
A neural network underlying intentional emotional facial expression in neurodegenerative disease.
|
|
|
|
BASE
|
|
Show details
|
|
|
| 10 |
Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia.
|
|
|
|
BASE
|
|
Show details
|
|
|
| 11 |
A neural network underlying intentional emotional facial expression in neurodegenerative disease.
|
|
|
|
BASE
|
|
Show details
|
|
|
| 12 |
Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia.
|
|
|
|
BASE
|
|
Show details
|
|
|
| 13 |
Impaired Recognition and Regulation of Disgust Is Associated with Distinct but Partially Overlapping Patterns of Decreased Gray Matter Volume in the Ventroanterior Insula.
|
|
|
|
In: Biological psychiatry, vol 78, iss 7 (2015)
|
|
BASE
|
|
Show details
|
|
|
| 14 |
Criminal behavior in frontotemporal dementia and Alzheimer disease.
|
|
|
|
In: JAMA neurology, vol 72, iss 3 (2015)
|
|
BASE
|
|
Show details
|
|
|
| 15 |
Neural basis of motivational approach and withdrawal behaviors in neurodegenerative disease.
|
|
Shinagawa, Shunichiro; Babu, Adhimoolam; Sturm, Virginia; Shany-Ur, Tal; Toofanian Ross, Parnian; Zackey, Diana; Poorzand, Pardis; Grossman, Scott; Miller, Bruce L; Rankin, Katherine P
|
|
In: Brain and behavior, vol 5, iss 9 (2015)
|
|
Abstract:
IntroductionThe Behavioral Inhibition System (BIS) and the Behavioral Activation System (BAS) have been theorized as neural systems that regulate approach/withdrawal behaviors. Behavioral activation/inhibition balance may change in neurodegenerative disease based on underlying alterations in systems supporting motivation and approach/withdrawal behaviors, which may in turn be reflected in neuropsychiatric symptoms.MethodA total of 187 participants (31 patients diagnosed with behavioral variant of FTD [bvFTD], 13 semantic variant of primary progressive aphasia [svPPA], 14 right temporal variant FTD [rtFTD], 54 Alzheimer's disease [AD], and 75 older healthy controls [NCs]) were included in this study. Changes in behavioral inhibition/activation were measured using the BIS/BAS scale. We analyzed the correlation between regional atrophy pattern and BIS/BAS score, using voxel-based morphometry (VBM).ResultsADs had significantly higher BIS scores than bvFTDs and NCs. bvFTDs activation-reward response (BAS-RR) was significantly lower than ADs and NCs, though their activation-drive (BAS-D) was significantly higher than in ADs. Both AD and rtFTD patients had abnormally low activation fun-seeking (BAS-FS) scores. BIS score correlated positively with right anterior cingulate and middle frontal gyrus volume, as well as volume in the right precentral gyrus and left insula/operculum.ConclusionsAD, bvFTD, and rtFTD patients show divergent patterns of change in approach/withdrawal reactivity. High BIS scores correlated with preservation of right-predominant structures involved in task control and self-protective avoidance of potentially negative reinforcers. Damage to these regions in bvFTD may create a punishment insensitivity that underlies patients' lack of self-consciousness in social contexts.
|
|
Keyword:
80 and over; Acquired Cognitive Impairment; Aged; Aging; Alzheimer's disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias; Alzheimer’s disease; and over; Basic Behavioral and Social Science; behavior inhibition; Behavioral and Social Science; Brain; Brain Disorders; Case-Control Studies; Clinical Research; Cognitive Sciences; Computer-Assisted; dementia; Emotions; Female; Frontotemporal Dementia; Humans; Image Processing; Magnetic Resonance Imaging; Male; Middle Aged; Motivation; neurodegeneration; Neurodegenerative; Neurosciences; Psychology; Punishment; Reward; Social Behavior; social concern; voxel-based morphometry
|
|
URL: https://escholarship.org/uc/item/68j7w60f
|
|
BASE
|
|
Hide details
|
|
|
| 16 |
Impaired Recognition and Regulation of Disgust Is Associated with Distinct but Partially Overlapping Patterns of Decreased Gray Matter Volume in the Ventroanterior Insula.
|
|
|
|
In: Biological psychiatry, vol 78, iss 7 (2015)
|
|
BASE
|
|
Show details
|
|
|
| 17 |
Criminal behavior in frontotemporal dementia and Alzheimer disease.
|
|
|
|
In: JAMA neurology, vol 72, iss 3 (2015)
|
|
BASE
|
|
Show details
|
|
|
| 18 |
Neural substrates of socioemotional self-awareness in neurodegenerative disease.
|
|
|
|
In: Brain and behavior, vol 4, iss 2 (2014)
|
|
BASE
|
|
Show details
|
|
|
|
|
