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Age-related differences in the neural bases of phonological and semantic processes in the context of task-irrelevant information.
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Comparing two facets of emotion perception across multiple neurodegenerative diseases.
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In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020)
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Comparing two facets of emotion perception across multiple neurodegenerative diseases.
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In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020)
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Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
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Lee, Suzee E; Sias, Ana C; Kosik, Eena L; Flagan, Taru M; Deng, Jersey; Chu, Stephanie A; Brown, Jesse A; Vidovszky, Anna A; Ramos, Eliana Marisa; Gorno-Tempini, Maria Luisa; Karydas, Anna M; Coppola, Giovanni; Geschwind, Daniel H; Rademakers, Rosa; Boeve, Bradley F; Boxer, Adam L; Rosen, Howard J; Miller, Bruce L; Seeley, William W. - : eScholarship, University of California, 2019
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Abstract:
Mutations in progranulin (GRN) cause heterogeneous clinical syndromes, including behavioral variant frontotemporal dementia (bvFTD), primary progressive aphasia (PPA), corticobasal syndrome (CBS) and Alzheimer-type dementia (AD-type dementia). Human studies have shown that presymptomatic GRN carriers feature reduced connectivity in the salience network, a system targeted in bvFTD. Mice with homozygous deletion of GRN, in contrast, show thalamo-cortical hypersynchrony due to aberrant pruning of inhibitory synapses onto thalamo-cortical projection neurons. No studies have systematically explored the intrinsic connectivity networks (ICNs) targeted by the four GRN-associated clinical syndromes, or have forged clear links between human and mouse model findings. We compared 17 preclinical GRN carriers (14 "presymptomatic" clinically normal and three "prodromal" with mild cognitive symptoms) to healthy controls to assess for differences in cognitive testing and gray matter volume. Using task-free fMRI, we assessed connectivity in the salience network, a non-fluent variant primary progressive aphasia network (nfvPPA), the perirolandic network (CBS), and the default mode network (AD-type dementia). GRN carriers and controls showed similar performance on cognitive testing. Although carriers showed little evidence of brain atrophy, markedly enhanced connectivity emerged in all four networks, and thalamo-cortical hyperconnectivity stood out as a unifying feature. Voxelwise assessment of whole brain degree centrality, an unbiased graph theoretical connectivity metric, confirmed thalamic hyperconnectivity. These results show that human GRN disease and the prevailing GRN mouse model share a thalamo-cortical network hypersynchrony phenotype. Longitudinal studies will determine whether this network physiology represents a compensatory response as carriers approach symptom onset, or an early and sustained preclinical manifestation of lifelong progranulin haploinsufficiency.
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Keyword:
2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Adult; Aged; Aging; Alzheimer's Disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer's Disease Related Dementias (ADRD); Behavioral and Social Science; Brain Disorders; Cerebral Cortex; Clinical Research; Cognitive Dysfunction; Connectome; Dementia; Female; Frontotemporal Dementia; Frontotemporal Dementia (FTD); GRN; Heterozygote; Humans; Magnetic Resonance Imaging; Male; Middle Aged; MRI; Nerve Net; Neurodegenerative; Neurological; Neurosciences; Prodromal Symptoms; Progranulin; Progranulins; Rare Diseases; Thalamus
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URL: https://escholarship.org/uc/item/6vv8g8qt
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Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
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Increased cortical reactivity to repeated tones at 8 months in infants with later ASD. ...
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Increased cortical reactivity to repeated tones at 8 months in infants with later ASD.
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Anterior insular thickness predicts speech sound learning ability in bilinguals.
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In: NeuroImage, vol 165 (2018)
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Improving language mapping in clinical fMRI through assessment of grammar.
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Improving language mapping in clinical fMRI through assessment of grammar.
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Abnormal semantic knowledge in a case of developmental amnesia.
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In: Brain and Mind Institute Researchers' Publications (2017)
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Cortical thickness increases after simultaneous interpretation training.
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In: Neuropsychologia, vol. 98, pp. 212-219 (2017)
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Natural speech reveals the semantic maps that tile human cerebral cortex.
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In: Nature, vol 532, iss 7600 (2016)
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The Yin and the Yang of Prediction: An fMRI Study of Semantic Predictive Processing
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Impaired Recognition and Regulation of Disgust Is Associated with Distinct but Partially Overlapping Patterns of Decreased Gray Matter Volume in the Ventroanterior Insula.
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In: Biological psychiatry, vol 78, iss 7 (2015)
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Impaired Recognition and Regulation of Disgust Is Associated with Distinct but Partially Overlapping Patterns of Decreased Gray Matter Volume in the Ventroanterior Insula.
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In: Biological psychiatry, vol 78, iss 7 (2015)
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Spatiotemporal distribution of cortical processing of first and second languages in bilinguals. I. Effects of proficiency and linguistic setting.
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In: Human brain mapping, vol 34, iss 11 (2013)
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Structural asymmetry of anterior insula: behavioral correlates and individual differences.
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In: Brain and language, vol 126, iss 2 (2013)
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The contribution of the left mid-fusiform cortical thickness to Chinese and English reading in a large Chinese sample.
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Exaggerated object affordance and absent automatic inhibition in alien hand syndrome.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2013)
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