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1
Cortical microstructure in primary progressive aphasia: a multicenter study.
In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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2
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
Abstract: IntroductionThe Frontotemporal Lobar Degeneration Module (FTLD-MOD) includes a neuropsychological battery designed to assess the clinical features of FTLD, although much is unknown about its utility. We investigated FTLD-MOD and Uniform Data Set 3.0 (UDS) language tests for differential diagnosis and disease monitoring.MethodsLinear regressions compared baseline performances in 1655 National Alzheimer's Coordinating Center participants (behavioral variant frontotemporal dementia (bvFTD, n=612), semantic variant primary progressive aphasia (svPPA, n=168), non-fluent/agrammatic variant PPA (nfvPPA, n=168), logopenic variant PPA (lvPPA, n=109), and controls (n=581)). Sample sizes to detect treatment effects were estimated using longitudinal data.ResultsAmong PPAs, the FTLD-MOD language tasks and UDS Multilingual Naming Test accurately discriminated svPPA. Number Span Forward best discriminated lvPPA; Phonemic:Semantic Fluency ratio was excellent for nfvPPA classification. UDS fluency and naming measures required the smallest sample size to detect meaningful change.DiscussionThe FTLD-MOD and UDS differentiated among PPA subtypes. UDS 3.0 measures performed best for longitudinal monitoring.
Keyword: Acquired Cognitive Impairment; Aging; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer's Disease Related Dementias (ADRD); Aphasia; Brain Disorders; Clinical Research; clinical trials; Clinical Trials and Supportive Activities; cognition; Dementia; differential diagnosis; endpoints; frontotemporal dementia; Frontotemporal Dementia (FTD); FTLD module; Genetics; longitudinal; Neurodegenerative; neuropsychology; Neurosciences; primary progressive aphasia; Rare Diseases; speech
URL: https://escholarship.org/uc/item/31v6d3qh
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3
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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4
Comparing two facets of emotion perception across multiple neurodegenerative diseases.
In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020)
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5
Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
Shdo, Suzanne M; Ranasinghe, Kamalini G; Sturm, Virginia E. - : eScholarship, University of California, 2020
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6
Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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7
Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
Shdo, Suzanne M; Ranasinghe, Kamalini G; Sturm, Virginia E. - : eScholarship, University of California, 2020
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8
Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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9
Comparing two facets of emotion perception across multiple neurodegenerative diseases.
In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020)
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10
Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
Lee, Suzee E; Sias, Ana C; Kosik, Eena L. - : eScholarship, University of California, 2019
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11
Physiological, behavioral and subjective sadness reactivity in frontotemporal dementia subtypes.
In: Social cognitive and affective neuroscience, vol 14, iss 12 (2019)
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12
Factors that predict diagnostic stability in neurodegenerative dementia.
In: Journal of neurology, vol 266, iss 8 (2019)
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13
Factors that predict diagnostic stability in neurodegenerative dementia.
In: Journal of neurology, vol 266, iss 8 (2019)
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14
Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
Lee, Suzee E; Sias, Ana C; Kosik, Eena L. - : eScholarship, University of California, 2019
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15
Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.
In: Brain communications, vol 1, iss 1 (2019)
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16
Physiological, behavioral and subjective sadness reactivity in frontotemporal dementia subtypes.
In: Social cognitive and affective neuroscience, vol 14, iss 12 (2019)
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17
Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory.
In: Annals of clinical and translational neurology, vol 5, iss 10 (2018)
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18
Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
In: JAMA neurology, vol 75, iss 3 (2018)
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19
Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory.
In: Annals of clinical and translational neurology, vol 5, iss 10 (2018)
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20
Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease.
Elahi, Fanny M; Marx, Gabe; Cobigo, Yann. - : eScholarship, University of California, 2017
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