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41
The Relationship between Expressive Language Sampling and Clinical Measures in Fragile X Syndrome and Typical Development.
In: Brain sciences, vol 10, iss 2 (2020)
Abstract: Language impairment is a core difficulty in fragile X syndrome (FXS), and yet standardized measures lack the sensitivity to assess developmental changes in the nature of these impairments. Expressive Language Sampling Narrative (ELS-N) has emerged as a promising new measure with research demonstrating its usefulness in a wide range of ages in developmental disabilities and typical development. We examined ELS-N results in FXS and age-matched typically developing (TD) controls along with cognitive, adaptive, and clinical measures. We found the groups differed significantly on all ELS-N variables. Cognitive abilities were related to lexical diversity, syntactic complexity, and unintelligibility for the FXS group, but only verbal abilities were related to syntactic complexity in TD. Autism spectrum disorder (ASD) symptomatology was related to less intelligibility in speech. Measures of hyperactivity were related to increased talkativeness and unintelligibility. In addition, FXS males in comparison to FXS females were more impaired in cognitive ability, ASD symptoms, hyperactivity, and anxiety. This study extends the previous ELS research, supporting its use in FXS research as a measure to characterize language abilities. It also demonstrates the relationships between ELS-N variables and measures of cognitive, adaptive, ASD symptoms, and clinical symptoms.
Keyword: 2.1 Biological and endogenous factors; 2.3 Psychological; ASD; Autism; Behavioral and Social Science; Brain Disorders; Clinical Research; Cognitive Sciences; expressive language sampling; Fragile X Syndrome; hyperactivity; Intellectual and Developmental Disabilities (IDD); intelligibility; language impairments; Mental Health; Neurosciences; Pediatric; Psychology; Rare Diseases; social and economic factors; talkativeness
URL: https://escholarship.org/uc/item/28w569fc
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42
Artificial intelligence approaches to predicting and detecting cognitive decline in older adults: A conceptual review.
Graham, Sarah A; Lee, Ellen E; Jeste, Dilip V. - : eScholarship, University of California, 2020
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43
Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
Lee, Suzee E; Sias, Ana C; Kosik, Eena L. - : eScholarship, University of California, 2019
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44
Physiological, behavioral and subjective sadness reactivity in frontotemporal dementia subtypes.
In: Social cognitive and affective neuroscience, vol 14, iss 12 (2019)
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45
Factors that predict diagnostic stability in neurodegenerative dementia.
In: Journal of neurology, vol 266, iss 8 (2019)
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46
Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia.
In: Alzheimer disease and associated disorders, vol 33, iss 3 (2019)
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47
Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
Toller, Gianina; Yang, Winson FZ; Brown, Jesse A. - : eScholarship, University of California, 2019
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48
Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
Lee, Suzee E; Sias, Ana C; Kosik, Eena L. - : eScholarship, University of California, 2019
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49
Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.
In: Brain communications, vol 1, iss 1 (2019)
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50
Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
Toller, Gianina; Yang, Winson FZ; Brown, Jesse A. - : eScholarship, University of California, 2019
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51
Physiological, behavioral and subjective sadness reactivity in frontotemporal dementia subtypes.
In: Social cognitive and affective neuroscience, vol 14, iss 12 (2019)
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52
Cortical encoding and decoding models of speech production
Chartier, Josh. - : eScholarship, University of California, 2019
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53
Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.
In: Scientific reports, vol 9, iss 1 (2019)
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54
Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.
In: Scientific reports, vol 9, iss 1 (2019)
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55
Relationships Between Domain-Specific Cognition and Regional Brain Structure in a Typically Developing Cohort
Curley, Lauren Butler. - : eScholarship, University of California, 2019
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56
Linguistic and Cultural Acceptability of a Spanish Translation of the Ohio State University Traumatic Brain Injury Identification Method Among Community-Dwelling Spanish-Dominant Older Adults.
In: Archives of rehabilitation research and clinical translation, vol 1, iss 3-4 (2019)
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57
Muggle or magical?: Electrophysiological investigations of variation in the language-knowledge interface during reading
Troyer, Melissa. - : eScholarship, University of California, 2019
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58
A Randomized Controlled Trial of Sertraline in Young Children With Autism Spectrum Disorder.
Potter, Laura A; Scholze, Danielle A; Biag, Hazel Maridith B. - : eScholarship, University of California, 2019
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59
Pathogenic variants in USP7 cause a neurodevelopmental disorder with speech delays, altered behavior, and neurologic anomalies.
In: Genetics in medicine : official journal of the American College of Medical Genetics, vol 21, iss 8 (2019)
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60
A Randomized Controlled Trial of Sertraline in Young Children With Autism Spectrum Disorder.
Potter, Laura A; Scholze, Danielle A; Biag, Hazel Maridith B. - : eScholarship, University of California, 2019
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