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41
The Relationship between Expressive Language Sampling and Clinical Measures in Fragile X Syndrome and Typical Development.
In: Brain sciences, vol 10, iss 2 (2020)
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42
Artificial intelligence approaches to predicting and detecting cognitive decline in older adults: A conceptual review.
Graham, Sarah A; Lee, Ellen E; Jeste, Dilip V. - : eScholarship, University of California, 2020
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43
Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
Lee, Suzee E; Sias, Ana C; Kosik, Eena L. - : eScholarship, University of California, 2019
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44
Physiological, behavioral and subjective sadness reactivity in frontotemporal dementia subtypes.
In: Social cognitive and affective neuroscience, vol 14, iss 12 (2019)
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45
Factors that predict diagnostic stability in neurodegenerative dementia.
In: Journal of neurology, vol 266, iss 8 (2019)
Abstract: ObjectiveTo determine the frequency and characteristics of clinical diagnostic change in frontotemporal dementia (FTD)-spectrum syndromes and Alzheimer's disease (AD)-type dementia.MethodsWe reviewed records and categorized diagnostic changes in patients seen ≥ 2 times with behavioral variant FTD (bvFTD, n = 99), nonfluent and semantic variant primary progressive aphasia (nfvPPA, n = 32; svPPA, n = 59), corticobasal syndrome (CBS, n = 40), progressive supranuclear palsy-Richardson syndrome (PSP-RS, n = 34), and AD-type dementia (n = 49). For bvFTD, we compared patients with and without diagnostic change, and assessed predictors of diagnostic change by logistic regression.ResultsInitial diagnoses changed infrequently at subsequent visits in svPPA (6.8%), PSP-RS (8.8%), and nfvPPA (12.5%), with rare changes largely involving clinicopathological overlap or diagnostic ambiguity. Changes in AD-type dementia (30.6%) and CBS (37.5%) were more common, but reflected greater specificity, predicted co-pathology, or overlapping syndromes. Diagnostic change in bvFTD was also common (32.3%), but more diverse, including motor neuron disease development, alternative neurodegenerative syndromes, and non-neurodegenerative diseases. Diagnostic change occurred more often in those who met possible rather than probable bvFTD criteria (70.6% vs 15.3%, p < 0.001). Patients with stable diagnoses showed greater overall impairment, bvFTD behavioral severity, and atrophy in core right-hemisphere bvFTD regions. Patients with diagnostic change had more severe depression (p < 0.05) and more frequent contributing, secondary diagnoses (p = 0.01), such as cerebrovascular disease. By logistic regression, the accuracy of predicting stable bvFTD diagnoses using first-visit data was 80%.ConclusionbvFTD displays more diverse diagnostic change than other neurodegenerative syndromes. First-visit bvFTD diagnoses may waver if based on meeting possible criteria only.
Keyword: Acquired Cognitive Impairment; Aged; Aging; Alzheimer Disease; Alzheimer's disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer's Disease Related Dementias (ADRD); Alzheimer’s disease; Aphasia; Brain Disorders; Clinical Research; Clinical Sciences; Corticobasal degeneration; Dementia; Female; Frontotemporal Dementia; Frontotemporal Dementia (FTD); Humans; Male; Middle Aged; Neurodegenerative; Neurodegenerative Diseases; Neurological; Neurology & Neurosurgery; Neurosciences; Predictive Value of Tests; Primary Progressive; Progressive; Progressive supranuclear palsy; Rare Diseases; Retrospective Studies; Supranuclear Palsy
URL: https://escholarship.org/uc/item/4rz1t2j1
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46
Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia.
In: Alzheimer disease and associated disorders, vol 33, iss 3 (2019)
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47
Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
Toller, Gianina; Yang, Winson FZ; Brown, Jesse A. - : eScholarship, University of California, 2019
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48
Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
Lee, Suzee E; Sias, Ana C; Kosik, Eena L. - : eScholarship, University of California, 2019
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49
Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.
In: Brain communications, vol 1, iss 1 (2019)
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50
Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
Toller, Gianina; Yang, Winson FZ; Brown, Jesse A. - : eScholarship, University of California, 2019
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51
Physiological, behavioral and subjective sadness reactivity in frontotemporal dementia subtypes.
In: Social cognitive and affective neuroscience, vol 14, iss 12 (2019)
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52
Cortical encoding and decoding models of speech production
Chartier, Josh. - : eScholarship, University of California, 2019
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53
Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.
In: Scientific reports, vol 9, iss 1 (2019)
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54
Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.
In: Scientific reports, vol 9, iss 1 (2019)
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55
Relationships Between Domain-Specific Cognition and Regional Brain Structure in a Typically Developing Cohort
Curley, Lauren Butler. - : eScholarship, University of California, 2019
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56
Linguistic and Cultural Acceptability of a Spanish Translation of the Ohio State University Traumatic Brain Injury Identification Method Among Community-Dwelling Spanish-Dominant Older Adults.
In: Archives of rehabilitation research and clinical translation, vol 1, iss 3-4 (2019)
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57
Muggle or magical?: Electrophysiological investigations of variation in the language-knowledge interface during reading
Troyer, Melissa. - : eScholarship, University of California, 2019
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58
A Randomized Controlled Trial of Sertraline in Young Children With Autism Spectrum Disorder.
Potter, Laura A; Scholze, Danielle A; Biag, Hazel Maridith B. - : eScholarship, University of California, 2019
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59
Pathogenic variants in USP7 cause a neurodevelopmental disorder with speech delays, altered behavior, and neurologic anomalies.
In: Genetics in medicine : official journal of the American College of Medical Genetics, vol 21, iss 8 (2019)
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60
A Randomized Controlled Trial of Sertraline in Young Children With Autism Spectrum Disorder.
Potter, Laura A; Scholze, Danielle A; Biag, Hazel Maridith B. - : eScholarship, University of California, 2019
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