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Cortical microstructure in primary progressive aphasia: a multicenter study.
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In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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| 2 |
Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
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| 3 |
Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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In: JAMA neurology, vol 75, iss 3 (2018)
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| 4 |
Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease.
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| 5 |
Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease.
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| 6 |
Effects of HIV and childhood trauma on brain morphometry and neurocognitive function.
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In: Journal of neurovirology, vol 22, iss 2 (2016)
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| 7 |
Multivariate pattern classification of pediatric Tourette syndrome using functional connectivity MRI.
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In: Developmental science, vol 19, iss 4 (2016)
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Abstract:
Tourette syndrome (TS) is a developmental neuropsychiatric disorder characterized by motor and vocal tics. Individuals with TS would benefit greatly from advances in prediction of symptom timecourse and treatment effectiveness. As a first step, we applied a multivariate method - support vector machine (SVM) classification - to test whether patterns in brain network activity, measured with resting state functional connectivity (RSFC) MRI, could predict diagnostic group membership for individuals. RSFC data from 42 children with TS (8-15yrs) and 42 unaffected controls (age, IQ, in-scanner movement matched) were included. While univariate tests identified no significant group differences, SVM classified group membership with ~70% accuracy (p<.001). We also report a novel adaptation of SVM binary classification that, in addition to an overall accuracy rate for the SVM, provides a confidence measure for the accurate classification of each individual. Our results support the contention that multivariate methods can better capture the complexity of some brain disorders, and hold promise for predicting prognosis and treatment outcome for individuals with TS.
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Keyword:
4.1 Discovery and preclinical testing of markers and technologies; 4.2 Evaluation of markers and technologies; Adolescent; Biomedical Imaging; Brain Disorders; Case-Control Studies; Child; Clinical Research; Cognitive Sciences; Developmental & Child Psychology; Female; Humans; Linguistics; Magnetic Resonance Imaging; Male; Models; Multivariate Analysis; Nerve Net; Neurodegenerative; Neurological; Neurosciences; Pediatric; Prognosis; Psychology; Rare Diseases; Support Vector Machine; Tourette Syndrome
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URL: https://escholarship.org/uc/item/8wr2h7pn
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| 8 |
Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease.
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In: Human brain mapping, vol 36, iss 11 (2015)
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| 9 |
Parallel ICA of FDG-PET and PiB-PET in three conditions with underlying Alzheimer's pathology.
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| 10 |
Parallel ICA of FDG-PET and PiB-PET in three conditions with underlying Alzheimer's pathology.
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| 11 |
Neuroimaging correlates of handwriting quality as children learn to read and write.
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| 12 |
Neuroimaging correlates of handwriting quality as children learn to read and write.
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| 13 |
White matter microstructure correlates of narrative production in typically developing children and children with high functioning autism.
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In: Neuropsychologia, vol 51, iss 10 (2013)
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| 14 |
White matter microstructure correlates of narrative production in typically developing children and children with high functioning autism.
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In: Neuropsychologia, vol 51, iss 10 (2013)
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| 15 |
Neural oscillatory correlates of speech auditory-motor integration in the cortex of healthy individuals and patients with schizophrenia
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In: Herman, Alexander Beaumont. (2013). Neural oscillatory correlates of speech auditory-motor integration in the cortex of healthy individuals and patients with schizophrenia. UC San Francisco: Bioengineering. Retrieved from: http://www.escholarship.org/uc/item/4sg0t34g (2013)
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| 16 |
Language proficiency modulates the recruitment of non-classical language areas in bilinguals.
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In: PloS one, vol 6, iss 3 (2011)
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