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Molecular brain (micro report) oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome ...
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Molecular brain (micro report) oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome ...
Abstract: Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by specific social symptoms, restricted interests, stereotyped repetitive behaviors, and delayed language development. The 3q29 microdeletion (3q29del), a recurrent copy number variant, confers a high risk for ASD and schizophrenia, and serves as an important pathological model for investigating the molecular pathogenesis of a large number of neurodevelopmental and psychiatric conditions. Recently, mouse models carrying a deletion of the chromosomal region corresponding to the human 3q29 region (Df/+ mice) were generated and demonstrated neurodevelopmental and psychiatric conditions associated behavioral abnormalities, pointing to the relevance of Df/+ mice as a model for these conditions with high construct and face validity. Currently, the molecular pathogenesis of these behavioral phenotypes in Df/+ mice remains unclear. The oxytocin (OXT) system plays a central role in social behavior across species and has a ...
Keyword: 111714 Mental Health; 69999 Biological Sciences not elsewhere classified; FOS Biological sciences; FOS Health sciences; FOS Sociology; Genetics; Medicine; Neuroscience; Sociology
URL: https://springernature.figshare.com/collections/Molecular_brain_micro_report_oxytocin_ameliorates_impaired_social_behavior_in_a_mouse_model_of_3q29_deletion_syndrome/5919154
https://dx.doi.org/10.6084/m9.figshare.c.5919154
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