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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 13 of 13 1 Mechanistic Model-based Drug Oral Absorption Analysis Wang, Kai. - 2021 BASE Show details 2 Sensory assessment and acceptability of coated tablets relationship between instrumental methods and human data Hofmanová, Justyna Katarzyna. - 2020 BASE Show details 3 Scribonius Largus' Compounding of Drugs (Compositiones medicamentorum): introduction, translation, and medico-historical comments Jocks, Ianto Thorvald. - 2020 BASE Show details 4 ASTHMA MANAGEMENT EXPERIENCE AMONG CULTURALLY AND LINGUISTICALLY DIVERSE (CALD) PEOPLE IN AUSTRALIA Alzayer, Reem. - : University of Sydney, 2020 BASE Show details 5 Drugs, Pharmacy, Healing Rites, and Ethnobotany: Therapeutic Writing in the Foundational Narratives of Puerto Rico and the Dominican Republic Nedvyga, Olga. - 2019 BASE Show details 6 Role of community pharmacists in enhancing health literacy of culturally and linguistically diverse community members Mohammad, Annim. - : The University of Sydney, 2017. : Faculty of Pharmacy, 2017 BASE Show details 7 Exploring the Knowledge, Attitudes, and Provision Practices Of Pharmacists in Ontario: A Mixed-Methods Study Dedicated to Emergency Contraception ... Chaumont, Andréanne. - : Université d'Ottawa / University of Ottawa, 2016 BASE Show details 8 Exploring the Knowledge, Attitudes, and Provision Practices Of Pharmacists in Ontario: A Mixed-Methods Study Dedicated to Emergency Contraception Chaumont, Andréanne. - : Université d'Ottawa / University of Ottawa, 2016 BASE Show details 9 Opening the door on student learning: using artefacts to explore pharmacy students’ learning practices Edwards, Ruth M.. - : University of Stirling, 2013 BASE Show details 10 An exploration of factors affecting the use of community pharmacy services by South Asians in Leicester Lakhani, Neena. - : De Montfort University, 2012. : Faculty of Health and Life Sciences, 2012 BASE Show details 11 Characteristics of Latino smokers in different stages of change living in Minnesota. Castellanos, Jose William. - 2011 BASE Show details 12 Arabisch-Deutsches Wörterbuch der Stoffe : aus den drei Naturreichen, die in arabischen alchemistischen Handschriften vorkommen ; nebst Anhang Verzeichnis chemischer Geräte Siggel, Alfred. - Berlin : Akad. Verl., 1950 MPI-SHH Linguistik Show details 13 Evolution of Eukaryal tRNA-Guanine Transglycosylase: Insight Gained from the Characterization of the Human and Escherichia coli tRNA-Guanine Transglycosylases. Chen, Yi-Chen Abstract: Of the approximately 100 tRNA modifications that have been identified thus far, queuine (Q, 7-((4, 5-cis-dihydroxy-2-cyclopenten-1-yl) amino) methyl-7-deazaguanine) is one of the most complicated. Although its physiological role is largely obscure, the Q modification of tRNA in eukarya has been suggested to be involved in cell differentiation, proliferation and response to oxidative stress. Additionally, the malfunction of Q modification has been correlated with several biological disorders. These observations have elicited an interest in acquiring a greater understanding of the physiological role(s) of the queuosine modification. To explore the biological significance of queuosine modification in eukarya, this dissertation work studied the key human enzyme, tRNA-guanine transglycosylase (TGT), which catalyzes the exchange of queuine for guanine in its substrate tRNAs. The eukaryal TGT was previously proposed to be a heterodimeric protein composed of queuine tRNA-ribosyltransferase 1 (QTRT1) and ubiquitin-specific protease 14 (USP14). However, physical and kinetic evidence that we have obtained make it clear that the human TGT consists of QTRT1 and its homologue, queuine tRNA-ribosyltransferase domain-containing 1 (QTRTD1). Additional mutagenesis studies reveal that QTRT1 is responsible for the transglycosylase activity. Our results along with previous observations by others also led us to propose that QTRTD1 not only assists in recognizing substrate tRNAs, but has also evolved into a queuine salvage enzyme that generates the heterocyclic substrate (queuine) for the transglycosylation. Future work is pending to validate the latter part of this hypothesis. To the best of our knowledge, we have also provided the first report of the kinetics of the eukaryal TGT via direct incorporation assays. In vitro kinetic studies reported in this dissertation demonstrate preferential heterocyclic substrate recognition for the human TGT. Follow-up work of wild-type and mutant, human and Escherichia coli TGTs confirmed that active site residues of both enzymes evolved to selectively recognize their cognate heterocyclic substrates. This work has provided a greater understanding of the eukaryal TGT via rigorous enzymatic characterization of the recombinant human and E. coli TGTs. Our results are consistent with the concept that the present forms of TGT have arisen via divergent evolution. ; Ph.D. ; Medicinal Chemistry ; University of Michigan, Horace H. Rackham School of Graduate Studies ; http://deepblue.lib.umich.edu/bitstream/2027.42/84565/1/yichenc_1.pdf Keyword: Biological Chemistry; Characterization of the Eukaryal TGT; Divergent Evolution of TGT; Health Sciences; Heterodimeric Subunit Structure; Human TRNA-guanine Transglycosylase; Pharmacy and Pharmacology; Queuosine Modification URL: https://hdl.handle.net/2027.42/84565 BASE Hide details

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