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Family history of FXTAS is associated with age-related cognitive-linguistic decline among mothers with the FMR1 premutation.
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In: Journal of neurodevelopmental disorders, vol 14, iss 1 (2022)
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Neural dynamics of semantic categorization in semantic variant of primary progressive aphasia.
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Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
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Yang, Winson FZ; Toller, Gianina; Shdo, Suzanne; Kotz, Sonja A; Brown, Jesse; Seeley, William W; Kramer, Joel H; Miller, Bruce L; Rankin, Katherine P. - : eScholarship, University of California, 2021
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Abstract:
ObjectiveStructural and task-based functional studies associate emotion reading with frontotemporal brain networks, though it remains unclear whether functional connectivity (FC) alone predicts emotion reading ability. The predominantly frontotemporal salience and semantic appraisal (SAN) networks are selectively impacted in neurodegenerative disease syndromes like behavioral-variant frontotemporal dementia (bvFTD) and semantic-variant primary progressive aphasia (svPPA). Accurate emotion identification diminishes in some of these patients, but studies investigating the source of this symptom in patients have predominantly examined structural rather than functional brain changes. Thus, we investigated the impact of altered connectivity on their emotion reading.MethodsOne-hundred-eighty-five participants (26 bvFTD, 21 svPPA, 24 non-fluent variant PPA, 24 progressive supranuclear palsy, 49 Alzheimer's disease, 41 neurologically healthy older controls) underwent task-free fMRI, and completed the Emotion Evaluation subtest of The Awareness of Social Inference Test (TASIT-EET), watching videos and selecting labels for actors' emotions.ResultsAs expected, patients averaged significantly worse on emotion reading, but with wide inter-individual variability. Across all groups, lower mean FC in the SAN, but not other ICNs, predicted worse TASIT-EET performance. Node-pair analysis revealed that emotion identification was predicted by FC between 1) right anterior temporal lobe (RaTL) and right anterior orbitofrontal (OFC), 2) RaTL and right posterior OFC, and 3) left basolateral amygdala and left posterior OFC.ConclusionEmotion reading test performance predicts FC in specific SAN regions mediating socioemotional semantics, personalized evaluations, and salience-driven attention, highlighting the value of emotion testing in clinical and research settings to index neural circuit dysfunction in patients with neurodegeneration and other neurologic disorders.
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Keyword:
2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aging; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Aphasia; Basic Behavioral and Social Science; Behavioral and Social Science; Brain; Brain Disorders; Clinical Research; Dementia; Emotion reading; Emotions; Frontotemporal Dementia; Frontotemporal Dementia (FTD); Functional connectivity; Humans; Magnetic Resonance Imaging; Neurodegeneration; Neurodegenerative; Neurodegenerative Diseases; Neurological; Neurosciences; Primary Progressive; Right anterior temporal lobe; Semantic appraisal network; Semantics
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URL: https://escholarship.org/uc/item/67m8f14f
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Adolescent Protective and Risk Factors for Incarceration through Early Adulthood
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In: JOURNAL OF CHILD AND FAMILY STUDIES, vol 30, iss 6 (2021)
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| 5 |
Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation.
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In: Human brain mapping, vol 42, iss 14 (2021)
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The effect of distance and frequency factors on the prominence of referential entities ; L’effet des facteurs de distance et de fréquence sur la saillance des entités référentielles
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In: ISSN: 0458-726X ; EISSN: 1958-9549 ; Langages ; https://hal.archives-ouvertes.fr/hal-03474751 ; Langages, Armand Colin (Larousse jusqu'en 2003), 2021, Un corpus annoté en chaînes de référence et son exploitation : le projet Democrat, pp.109-128 ; https://www.revues.armand-colin.com/lettres-langues/langages/langages-no-224-42021/ (2021)
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Evidence of the interplay of genetics and culture in Ethiopia. ...
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Web indirect language assessment on monolingual Italian toddlers ...
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Infant and Toddler Child-Care Quality and Stability in Relation to Proximal and Distal Academic and Social Outcomes.
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Do women and men use language differently in spoken face-to-face interaction? A scoping review
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In: Review of Communication Research ; 9 ; 43-79 (2021)
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| 11 |
Evidence of the interplay of genetics and culture in Ethiopia.
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In: essn: 2041-1723 ; nlmid: 101528555 (2021)
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| 12 |
Problems in Foreign Language Education in the Turkish Education System: Pre-Service Teachers’ Accounts
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In: Eurasian Journal of Applied Linguistics, Vol 7, Iss 1, Pp 397-419 (2021) (2021)
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| 13 |
Expressive language development in adolescents with Down syndrome and fragile X syndrome: change over time and the role of family-related factors.
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In: Journal of neurodevelopmental disorders, vol 12, iss 1 (2020)
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| 14 |
Comparing two facets of emotion perception across multiple neurodegenerative diseases.
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In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020)
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| 15 |
Amount and delay insensitivity during intertemporal choice in three neurodegenerative diseases reflects dorsomedial prefrontal atrophy.
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Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
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Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
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Amount and delay insensitivity during intertemporal choice in three neurodegenerative diseases reflects dorsomedial prefrontal atrophy.
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| 19 |
A neurophysiological model of speech production deficits in fragile X syndrome.
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In: Brain communications, vol 2, iss 1 (2020)
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The Relationship between Expressive Language Sampling and Clinical Measures in Fragile X Syndrome and Typical Development.
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In: Brain sciences, vol 10, iss 2 (2020)
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