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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 14 of 14 1 Speech production differences in English and Italian speakers with nonfluent variant PPA Canu, Elisa; Agosta, Federica; Battistella, Giovanni... In: Neurology (2020) BASE Show details 2 Moving Toward Non-transcription Based Discourse Analysis in Stable and Progressive Aphasia Dalton, Sarah Grace; Hubbard, H. Isabel; Richardson, Jessica D. In: Speech Pathology and Audiology Faculty Research and Publications (2019) BASE Show details 3 Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates VINCETI, GIULIA; OLNEY, NICHOLAS; MANDELLI, MARIA LUISA. - 2019 BASE Show details 4 Neurocognitive basis of repetition deficits in primary progressive aphasia Lukic, Sladjana; Mandelli, Maria Luisa; Welch, Ariane. - 2019 BASE Show details 5 Verbal Semantics and the Left Dorsolateral Anterior Temporal Lobe: A Longitudinal Case of Bilateral Temporal Degeneration Vonk, Jet M. J.; Borghesani, Valentina; Battistella, Giovanni... In: Aphasiology (2019) BASE Show details 6 Semantic and lexical features of words dissimilarly affected by non-fluent, logopenic, and semantic primary progressive aphasia Vonk, Jet M. J.; Jonkers, Roel; Hubbard, H. Isabel. - 2019 BASE Show details 7 Neurocognitive Basis of Repetition Deficits in Primary Progressive Aphasia Lukic, Sladjana; Mandelli, Maria Luisa; Welch, Ariane... In: Communication Sciences and Disorders Faculty Publications (2019) BASE Show details 8 Prevalence of Mathematical and Visuospatial Learning Disabilities in Patients With Posterior Cortical Atrophy Miller, Zachary A.; Rosenberg, Lynne; Santos-Santos, Miguel A.. - : American Medical Association, 2018 BASE Show details 9 Visuospatial Functioning In The Primary Progressive Aphasias Watson, Christa L.; Possin, Katherine; Allen, I. Elaine. - : Cambridge Univ Press, 2018 BASE Show details 10 Rates Of Amyloid Imaging Positivity In Patients With Primary Progressive Aphasia Santos-Santos, Miguel A.; Rabinovici, Gil D.; Laccarino, Leonardo. - : Amer Medical Assoc, 2018 BASE Show details 11 Visuospatial Functioning in the Primary Progressive Aphasias Watson, Christa L.; Possin, Katherine; Allen, I. Elaine. - 2017 BASE Show details 12 Healthy brain connectivity predicts atrophy progression in non-fluent variant of primary progressive aphasia Mandelli, Maria Luisa; Vilaplana, Eduard; Brown, Jesse A.. - : Oxford University Press, 2016 BASE Show details 13 Cross-sectional and longitudinal features of non-fluent/agrammatic primary progressive aphasia with underlying corticobasal degeneration or progressive supranuclear palsy pathology Santos-Santos, Miguel A.; Mandelli, Maria Luisa; Binney, Richard J.. - 2016 BASE Show details 14 Speech entrainment enables patients with Broca's aphasia to produce fluent speech Fridriksson, Julius; Hubbard, H. Isabel; Hudspeth, Sarah Grace; Holland, Audrey L.; Bonilha, Leonardo; Fromm, Davida; Rorden, Chris. - : Oxford University Press, 2012 Abstract: A distinguishing feature of Broca’s aphasia is non-fluent halting speech typically involving one to three words per utterance. Yet, despite such profound impairments, some patients can mimic audio-visual speech stimuli enabling them to produce fluent speech in real time. We call this effect ‘speech entrainment’ and reveal its neural mechanism as well as explore its usefulness as a treatment for speech production in Broca’s aphasia. In Experiment 1, 13 patients with Broca’s aphasia were tested in three conditions: (i) speech entrainment with audio-visual feedback where they attempted to mimic a speaker whose mouth was seen on an iPod screen; (ii) speech entrainment with audio-only feedback where patients mimicked heard speech; and (iii) spontaneous speech where patients spoke freely about assigned topics. The patients produced a greater variety of words using audio-visual feedback compared with audio-only feedback and spontaneous speech. No difference was found between audio-only feedback and spontaneous speech. In Experiment 2, 10 of the 13 patients included in Experiment 1 and 20 control subjects underwent functional magnetic resonance imaging to determine the neural mechanism that supports speech entrainment. Group results with patients and controls revealed greater bilateral cortical activation for speech produced during speech entrainment compared with spontaneous speech at the junction of the anterior insula and Brodmann area 47, in Brodmann area 37, and unilaterally in the left middle temporal gyrus and the dorsal portion of Broca’s area. Probabilistic white matter tracts constructed for these regions in the normal subjects revealed a structural network connected via the corpus callosum and ventral fibres through the extreme capsule. Unilateral areas were connected via the arcuate fasciculus. In Experiment 3, all patients included in Experiment 1 participated in a 6-week treatment phase using speech entrainment to improve speech production. Behavioural and functional magnetic resonance imaging data were collected before and after the treatment phase. Patients were able to produce a greater variety of words with and without speech entrainment at 1 and 6 weeks after training. Treatment-related decrease in cortical activation associated with speech entrainment was found in areas of the left posterior-inferior parietal lobe. We conclude that speech entrainment allows patients with Broca’s aphasia to double their speech output compared with spontaneous speech. Neuroimaging results suggest that speech entrainment allows patients to produce fluent speech by providing an external gating mechanism that yokes a ventral language network that encodes conceptual aspects of speech. Preliminary results suggest that training with speech entrainment improves speech production in Broca’s aphasia providing a potential therapeutic method for a disorder that has been shown to be particularly resistant to treatment. Keyword: Original Articles URL: http://brain.oxfordjournals.org/cgi/content/short/135/12/3815 https://doi.org/10.1093/brain/aws301 BASE Hide details

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