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    • Hubbard, H. Isabel (13)
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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 14 of 14 1 Speech production differences in English and Italian speakers with nonfluent variant PPA Canu, Elisa; Agosta, Federica; Battistella, Giovanni; Spinelli, Edoardo G.; DeLeon, Jessica; Welch, Ariane E.; Mandelli, Maria Luisa; Hubbard, H. Isabel; Moro, Andrea; Magnani, Giuseppe; Cappa, Stefano F.; Miller, Bruce L.; Filippi, Massimo; Gorno-Tempini, Maria Luisa In: Neurology (2020) Abstract: OBJECTIVE: To understand whether the clinical phenotype of nonfluent/agrammatic primary progressive aphasia (nfvPPA) could present differences depending on the patient’s native language. METHODS: In this cross-sectional study, we analyzed connected speech samples in monolingual English (nfvPPA-E) and Italian speakers (nfvPPA-I) who were diagnosed with nfvPPA and matched for age, sex, and Mini-Mental State Examination scores. Patients also received a comprehensive neuropsychological battery. All patients and 2 groups of age-matched healthy controls underwent an MRI scan with 3D T1-weighted sequences. Connected speech measures and the other cognitive features were compared between patient groups. MRI variables, in terms of gray matter volume, were compared between each patient group and the corresponding controls. RESULTS: Compared to nfvPPA-E, nfvPPA-I had fewer years of education and shorter reported disease duration. The 2 groups showed similar regional atrophy compatible with clinical diagnosis. Patients did not differ in nonlanguage domains, comprising executive scores. Connected speech sample analysis showed that nfvPPA-E had significantly more distortions than nfvPPA-I, while nfvPPA-I showed reduced scores in some measures of syntactic complexity. On language measures, Italian speakers performed more poorly on syntactic comprehension. CONCLUSIONS: nfvPPA-E showed greater motor speech impairment than nfvPPA-I despite higher level of education and comparable disease severity and atrophy changes. The data also suggest greater grammatical impairment in nfvPPA-I. This study illustrates the need to take into account the possible effect of the individual's spoken language on the phenotype and clinical presentation of primary progressive aphasia variants. Keyword: Article URL: https://doi.org/10.1212/WNL.0000000000008879 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238919/ http://www.ncbi.nlm.nih.gov/pubmed/31924679 BASE Hide details 2 Moving Toward Non-transcription Based Discourse Analysis in Stable and Progressive Aphasia Dalton, Sarah Grace; Hubbard, H. Isabel; Richardson, Jessica D. In: Speech Pathology and Audiology Faculty Research and Publications (2019) BASE Show details 3 Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates VINCETI, GIULIA; OLNEY, NICHOLAS; MANDELLI, MARIA LUISA. - 2019 BASE Show details 4 Neurocognitive basis of repetition deficits in primary progressive aphasia Lukic, Sladjana; Mandelli, Maria Luisa; Welch, Ariane. - 2019 BASE Show details 5 Verbal Semantics and the Left Dorsolateral Anterior Temporal Lobe: A Longitudinal Case of Bilateral Temporal Degeneration Vonk, Jet M. J.; Borghesani, Valentina; Battistella, Giovanni... In: Aphasiology (2019) BASE Show details 6 Semantic and lexical features of words dissimilarly affected by non-fluent, logopenic, and semantic primary progressive aphasia Vonk, Jet M. J.; Jonkers, Roel; Hubbard, H. Isabel. - 2019 BASE Show details 7 Neurocognitive Basis of Repetition Deficits in Primary Progressive Aphasia Lukic, Sladjana; Mandelli, Maria Luisa; Welch, Ariane... In: Communication Sciences and Disorders Faculty Publications (2019) BASE Show details 8 Prevalence of Mathematical and Visuospatial Learning Disabilities in Patients With Posterior Cortical Atrophy Miller, Zachary A.; Rosenberg, Lynne; Santos-Santos, Miguel A.. - : American Medical Association, 2018 BASE Show details 9 Visuospatial Functioning In The Primary Progressive Aphasias Watson, Christa L.; Possin, Katherine; Allen, I. Elaine. - : Cambridge Univ Press, 2018 BASE Show details 10 Rates Of Amyloid Imaging Positivity In Patients With Primary Progressive Aphasia Santos-Santos, Miguel A.; Rabinovici, Gil D.; Laccarino, Leonardo. - : Amer Medical Assoc, 2018 BASE Show details 11 Visuospatial Functioning in the Primary Progressive Aphasias Watson, Christa L.; Possin, Katherine; Allen, I. Elaine. - 2017 BASE Show details 12 Healthy brain connectivity predicts atrophy progression in non-fluent variant of primary progressive aphasia Mandelli, Maria Luisa; Vilaplana, Eduard; Brown, Jesse A.. - : Oxford University Press, 2016 BASE Show details 13 Cross-sectional and longitudinal features of non-fluent/agrammatic primary progressive aphasia with underlying corticobasal degeneration or progressive supranuclear palsy pathology Santos-Santos, Miguel A.; Mandelli, Maria Luisa; Binney, Richard J.. - 2016 BASE Show details 14 Speech entrainment enables patients with Broca's aphasia to produce fluent speech Fridriksson, Julius; Hubbard, H. Isabel; Hudspeth, Sarah Grace. - : Oxford University Press, 2012 BASE Show details

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