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1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans
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Functional organisation for verb generation in children with developmental language disorder
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In: Neuroimage (2021)
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Abstract:
Developmental language disorder (DLD) is characterised by difficulties in learning one's native language for no apparent reason. These language difficulties occur in 7% of children and are known to limit future academic and social achievement. Our understanding of the brain abnormalities associated with DLD is limited. Here, we used a simple four-minute verb generation task (children saw a picture of an object and were instructed to say an action that goes with that object) to test children between the ages of 10–15 years (DLD N = 50, typically developing N = 67). We also tested 26 children with poor language ability who did not meet our criteria for DLD. Contrary to our registered predictions, we found that children with DLD did not have (i) reduced activity in language relevant regions such as the left inferior frontal cortex; (ii) dysfunctional striatal activity during overt production; or (iii) a reduction in left-lateralised activity in frontal cortex. Indeed, performance of this simple language task evoked activity in children with DLD in the same regions and to a similar level as in typically developing children. Consistent with previous reports, we found sub-threshold group differences in the left inferior frontal gyrus and caudate nuclei, but only when analysis was limited to a subsample of the DLD group (N = 14) who had the poorest performance on the task. Additionally, we used a two-factor model to capture variation in all children studied (N = 143) on a range of neuropsychological tests and found that these language and verbal memory factors correlated with activity in different brain regions. Our findings indicate a lack of support for some neurological models of atypical language learning, such as the procedural deficit hypothesis or the atypical lateralization hypothesis, at least when using simple language tasks that children can perform. These results also emphasise the importance of controlling for and monitoring task performance.
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Article
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836232/ http://www.ncbi.nlm.nih.gov/pubmed/33285329 https://doi.org/10.1016/j.neuroimage.2020.117599
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Investigating the effects of handedness on the consistency of lateralization for speech production and semantic processing tasks using functional transcranial Doppler sonography
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Profile of language abilities in a sample of adults with developmental disorders
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Functional organisation for verb generation in children with developmental language disorder
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PP30 The ambulance service and the child and young persons advance care plan: listening to families and professionals
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Profile of language abilities in a sample of adults with developmental disorders
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In: Dyslexia (2020)
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Investigation into inconsistent lateralisation of language functions as a potential risk factor for language impairment
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Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets
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In: ISSN: 2041-1723 ; EISSN: 2041-1723 ; Nature Communications ; https://hal.archives-ouvertes.fr/hal-02365089 ; Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-13005-8⟩ (2019)
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Sulcal morphology in Alzheimer's disease: an effective marker of diagnosis and cognition
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In: ISSN: 0197-4580 ; Neurobiology of Aging ; https://www.hal.inserm.fr/inserm-02266990 ; Neurobiology of Aging, Elsevier, 2019, Epub ahead of print. ⟨10.1016/j.neurobiolaging.2019.07.015⟩ (2019)
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Investigation into inconsistent lateralisation of language functions as a potential risk factor for language impairment
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The understanding of complex syntax in children with Down syndrome [version 2; peer review: 3 approved]
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Assessing children's understanding of complex syntax : a comparison of two methods
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Testing the unitary theory of language lateralization using functional transcranial Doppler sonography in adults
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Identification of research hypotheses and new knowledge from scientific literature ...
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Identification of research hypotheses and new knowledge from scientific literature ...
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The understanding of complex syntax in children with Down syndrome
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Growth in syntactic complexity between four years and adulthood : evidence from a narrative task
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Phase 2 of CATALISE: a multinational and multidisciplinary Delphi consensus study of problems with language development: terminology
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