| 1 |
Dynamic functional brain network connectivity during pseudoword processing relates to children’s reading skill
|
|
|
|
BASE
|
|
Show details
|
|
|
| 2 |
Teaching vocabulary to adolescents with language disorder: Perspectives from teachers and speech and language therapists
|
|
|
|
BASE
|
|
Show details
|
|
|
| 3 |
Family history of FXTAS is associated with age-related cognitive-linguistic decline among mothers with the FMR1 premutation.
|
|
|
|
In: Journal of neurodevelopmental disorders, vol 14, iss 1 (2022)
|
|
Abstract:
BackgroundWomen who carry a premutation allele of the FMR1 gene are at increased vulnerability to an array of age-related symptoms and disorders, including age-related decline in select cognitive skills. However, the risk factors for age-related decline are poorly understood, including the potential role of family history and genetic factors. In other forms of pathological aging, early decline in syntactic complexity is observed and predicts the later onset of neurodegenerative disease. To shed light on the earliest signs of degeneration, the present study characterized longitudinal changes in the syntactic complexity of women with the FMR1 premutation across midlife, and associations with family history of fragile X-associated tremor/ataxia syndrome (FXTAS) and CGG repeat length.MethodsForty-five women with the FMR1 premutation aged 35-64years at study entry participated in 1-5 longitudinal assessments spaced approximately a year apart (130 observations total). All participants were mothers of children with confirmed fragile X syndrome. Language samples were analyzed for syntactic complexity and participants provided information on family history of FXTAS. CGG repeat length was determined via molecular genetic testing.ResultsHierarchical linear models indicated that women who reported a family history of FXTAS exhibited faster age-related decline in syntactic complexity than those without a family history, with that difference emerging as the women reached their mid-50s. CGG repeat length was not a significant predictor of age-related change.ConclusionsResults suggest that women with the FMR1 premutation who have a family history of FXTAS may be at increased risk for neurodegenerative disease, as indicated by age-related loss of syntactic complexity. Thus, family history of FXTAS may represent a personalized risk factor for age-related disease. Follow-up study is needed to determine whether syntactic decline is an early indicator of FXTAS specifically, as opposed to being a more general age-related cognitive decline associated with the FMR1 premutation.
|
|
Keyword:
2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Adult; Aging; Alleles; Alzheimer's Disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Ataxia; Behavioral and Social Science; Brain Disorders; Child; Clinical Research; Cognitive Dysfunction; Dementia; Female; Fragile X Mental Retardation Protein; Fragile X premutation; Fragile X Syndrome; Genetics; Grammatical complexity; Humans; Intellectual and Developmental Disabilities (IDD); Language Disorders; Language production; Middle Aged; Mothers; Neurodegenerative; Neurodegenerative Diseases; Neurological; Neurosciences; Pediatric; Psychology; Rare Diseases; Tremor
|
|
URL: https://escholarship.org/uc/item/2m78r62b
|
|
BASE
|
|
Hide details
|
|
|
| 4 |
НАРУШЕНИЕ ПРАВИЛ РЕЧЕВОЙ КОММУНИКАЦИИ ПЕРСОНАЖА-РЕБЕНКА: ОРИГИНАЛ И ПЕРЕВОД ... : A CHILD CHARACTER'S VIOLATION OF COMMUNICATION RULES: ORIGINAL TEXT AND TRANSLATION ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 5 |
A CHILD CHARACTER'S VIOLATION OF COMMUNICATION RULES: ORIGINAL TEXT AND TRANSLATION ... : НАРУШЕНИЕ ПРАВИЛ РЕЧЕВОЙ КОММУНИКАЦИИ ПЕРСОНАЖА-РЕБЕНКА: ОРИГИНАЛ И ПЕРЕВОД ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 7 |
The Language Exposure Assessment Tool (DeAnda et al., 2016) ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 9 |
The Language Exposure Assessment Tool (DeAnda et al., 2016) ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 10 |
It’s your turn: The dynamics of conversational turn-taking in father-child and mother-child interaction ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 11 |
RCT assessing the effectiveness of Háblame Bebé (Larson et al., 2022) ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 12 |
RCT assessing the effectiveness of Háblame Bebé (Larson et al., 2022) ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 13 |
Continuity of Communication and Language Development (Määttä et al., 2016) ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 14 |
Continuity of Communication and Language Development (Määttä et al., 2016) ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 16 |
Sentence Comprehension Deficits of Specific Language Impairment (Montgomery et al., 2016) ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 17 |
Reliability of short language samples (Wilder & Redmond, 2022) ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 18 |
Sentence repetition as a clinical marker for Mandarin DLD (Wang et al., 2022) ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 19 |
Longitudinal Effects on Adolescent Language (Harlaar et al., 2016) ...
|
|
|
|
BASE
|
|
Show details
|
|
|
|
|
