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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 7 of 7 1 Language-enhanced cognitive skills model ... Ubalde, Josep; Alarcón, Amado. - : Zenodo, 2022 BASE Show details 2 Language-enhanced cognitive skills model ... Ubalde, Josep; Alarcón, Amado. - : Zenodo, 2022 BASE Show details 3 MODERN APPROACHES TO TEAM BUILDING TECHNOLOGY IN TEACHING A FOREIGN LANGUAGE IN A NON-LINGUISTIC UNIVERSITY ... Uvarov, V.. - : The Scientific Heritage, 2021 BASE Show details 4 Global coherence in aphasia during conversation (Leaman & Edmonds, 2020) Marion C. Leaman (6251904); Lisa A. Edmonds (4689190). - 2020 BASE Show details 5 An Aetiological Foxp2 Mutation Causes Aberrant Striatal Activity and Alters Plasticity during Skill Learning : Nature Publishing Group, 2012 Abstract: Abstract Mutations in the human FOXP2 gene cause impaired speech development and linguistic deficits, which have been best characterized in a large pedigree called the KE family. The encoded protein is highly conserved in many vertebrates and is expressed in homologous brain regions required for sensorimotor integration and motor-skill learning, in particular cortico-striatal circuits. Independent studies in multiple species suggest that the striatum is a key site of FOXP2 action. Here we used in vivo recordings in awake behaving mice to investigate the effects of the KE-family mutation on the function of striatal circuits during motor-skill learning. We uncovered abnormally high ongoing striatal activity in mice carrying an identical mutation to that of the KE-family. Furthermore, there were dramatic alterations in striatal plasticity during the acquisition of a motor-skill, with most neurons in mutants showing negative modulation of firing rate, starkly contrasting with the predominantly positive modulation seen in control animals. We also observed striking changes in the temporal coordination of striatal firing during motor-skill learning in mutants. Our results indicate that FOXP2 is critical for the function of striatal circuits in vivo, which are important not only for speech but also for other striatal-dependent skills. ; ruicosta@fchampalimaud.org (Costa, Rui M) ; Champalimaud Neuroscience Programme - Rua da Quinta Grande 6, Oeiras, Portugal 2780-901--> - PORTUGAL (Costa, Rui M) ; Champalimaud Neuroscience Programme - Rua da Quinta Grande 6, Oeiras, Portugal 2780-901--> - PORTUGAL (French, Catherine Ann) ; Champalimaud Neuroscience Programme - Rua da Quinta Grande 6, Oeiras, Portugal 2780-901--> - PORTUGAL (Jin, Xin) ; Champalimaud Neuroscience Programme - Rua da Quinta Grande 6, Oeiras, Portugal 2780-901--> - PORTUGAL (Campbell, Thomas G) ; Champalimaud Neuroscience Programme - Rua da Quinta Grande 6, Oeiras, Portugal 2780-901--> - PORTUGAL (Gerfen, Elissa) ; Champalimaud Neuroscience Programme - Rua da Quinta Grande 6, Oeiras, Portugal 2780-901--> - PORTUGAL (Groszer, Matthias) ; Champalimaud Neuroscience Programme - Rua da Quinta Grande 6, Oeiras, Portugal 2780-901--> - PORTUGAL (Fisher, Simon) ; PORTUGAL ; Accepted: 2011-06-03 ; Received: 2011-01-20 ; Revised: 2011-05-24 Keyword: Foxp2; in vivo recording; KE family; motor-skill learning; speech and language; striatum URL: http://hdl.handle.net/2262/62440 https://doi.org/10.1038/mp.2011.105 BASE Hide details 6 Over-education in multilingual economies: evidence from Catalonia Blázquez, Maite; Rendón, Sílvio. - : Bonn: Institute for the Study of Labor (IZA), 2007 BASE Show details 7 English as the Language of Trade, Finance and Technology in APEC: An East Asia Perspective Lazaro, Dorothea C.; Medalla, Erlinda M.. - : Makati City: Philippine Institute for Development Studies (PIDS), 2004 BASE Show details

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