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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 12 of 12 1 Cognitive and Neural Control in Bilingual Language Processing Stasenko, Alena. - : eScholarship, University of California, 2020 BASE Show details 2 Cleaning up translation failures: how Ribosome-associated Quality Control maintains cellular proteostasis Hickey, Kelsey. - : eScholarship, University of California, 2020 Abstract: Ribosome-associated Quality Control (RQC) pathways protect cells from toxicity caused by incomplete protein products resulting from translation of damaged or problematic mRNAs. One component of the RQC pathway, Ltn1p, is an E3 ubiquitin ligase that targets partially synthesized polypeptides for ubiquitin-proteasome mediated degradation. A second core RQC component, Rqc2p, not only nucleates the complex formation but also modifies the nascent polypeptide by adding a carboxyl-terminal alanine and threonine (CAT) tail through a noncanonical elongation reaction. We found that Ltn1p can efficiently access only nascent-chain lysines immediately proximal to the ribosome exit tunnel. For substrates without Ltn1p-accessible lysines, CAT-tailing by Rqc2p expanded the range of RQC-degradable substrates by exposing lysines sequestered in the ribosome exit tunnel. Although the core RQC factors are conserved from yeast to human, much less is known about the mammalian counterparts. Interestingly, the phenotypes observed with loss of RQC in mammals are more severe and include cytotoxicity at a cellular level, and neurodegeneration at an organismal level. Due to the increased requirement for RQC in mammals, we used CRISPR-Cas9-based screening to search for additional RQC strategies in mammals. We found that failed translation leads to specific inhibition of translation initiation on that message. This negative feedback loop is mediated by two translation inhibitors, GIGYF2 and 4EHP. Both model substrates and growth-based assays established that inhibition of additional rounds of translation acts in concert with known RQC pathways to prevent buildup of toxic proteins. Inability to block translation of faulty mRNAs, and subsequent accumulation of partially synthesized polypeptides, could explain the neurodevelopmental and neuropsychiatric disorders observed in mice and humans with compromised GIGYF2 function. Keyword: Cellular biology; Genetics; Molecular biology; protein quality control; ribosome stalling; translation inhibition; ubiquitination URL: https://escholarship.org/uc/item/5bb92862 BASE Hide details 3 The Role of Cognitive Control in Understanding Speech in Noise Plock, Sarah In: Honors Theses at the University of Iowa (2019) BASE Show details 4 Лексические показатели развития речи у дошкольников с разным уровнем саморегуляции ... : Lexical Indicators of Speech Development in Preschool Children with Different Levels of Self-Regulation ... Алмазова Ольга Викторовна; Бухаленкова Дарья Алексеевна; Гаврилова Маргарита Николаевна. - : Современное дошкольное образование. Теория и практика, 2018 BASE Show details 5 非漢字系日本語学習者の漢字学習における阻害要因とその対処法 : 体系的な漢字学習の支援を目指して ヴォロビヨワ ガリーナ; ヴォロビヨフ ヴィクトル; Galina VOROBEVA. - : 国立国語研究所, 2017 BASE Show details 6 Multilinguals' language control Mosca, Michela. - : Sydney, Australia : Macquarie University, 2017 BASE Show details 7 Behavioral approach and fear moderates the relationship between insensitive/intrusive parenting and early language development Richier, C.J., 1992--. - 2016 BASE Show details 8 Testing the Bilingual Advantage Hypothesis: An Individual Differences Study on Rates of Mind Wandering Peralta, Joaquin. - : University of Oregon, 2015 BASE Show details 9 L'agressivité physique chez les enfants maltraités d'âge préscolaire en lien avec les habiletés verbales, le contrôle inhibiteur et les interactions mère-enfant Dubois, Laurie. - 2015 BASE Show details 10 Rumination and inhibitory difficulties: exploring the role of state rumination with emotionally self-relevant words Foxworth, Tamara; NC DOCKS at The University of North Carolina at Greensboro. - 2014 BASE Show details 11 Aging and inhibitory control Gordon, Brian A.. - 2010 BASE Show details 12 Normal and pathological language control in bilinguals Green, D In: In: (Proceedings) Workshop on bilingualism:neurolinguistic and psycholinguistic perspectives. BASE Show details

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