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1
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
Abstract: IntroductionThe Frontotemporal Lobar Degeneration Module (FTLD-MOD) includes a neuropsychological battery designed to assess the clinical features of FTLD, although much is unknown about its utility. We investigated FTLD-MOD and Uniform Data Set 3.0 (UDS) language tests for differential diagnosis and disease monitoring.MethodsLinear regressions compared baseline performances in 1655 National Alzheimer's Coordinating Center participants (behavioral variant frontotemporal dementia (bvFTD, n=612), semantic variant primary progressive aphasia (svPPA, n=168), non-fluent/agrammatic variant PPA (nfvPPA, n=168), logopenic variant PPA (lvPPA, n=109), and controls (n=581)). Sample sizes to detect treatment effects were estimated using longitudinal data.ResultsAmong PPAs, the FTLD-MOD language tasks and UDS Multilingual Naming Test accurately discriminated svPPA. Number Span Forward best discriminated lvPPA; Phonemic:Semantic Fluency ratio was excellent for nfvPPA classification. UDS fluency and naming measures required the smallest sample size to detect meaningful change.DiscussionThe FTLD-MOD and UDS differentiated among PPA subtypes. UDS 3.0 measures performed best for longitudinal monitoring.
Keyword: Acquired Cognitive Impairment; Aging; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer's Disease Related Dementias (ADRD); Aphasia; Brain Disorders; Clinical Research; clinical trials; Clinical Trials and Supportive Activities; cognition; Dementia; differential diagnosis; endpoints; frontotemporal dementia; Frontotemporal Dementia (FTD); FTLD module; Genetics; longitudinal; Neurodegenerative; neuropsychology; Neurosciences; primary progressive aphasia; Rare Diseases; speech
URL: https://escholarship.org/uc/item/31v6d3qh
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2
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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3
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring
In: Alzheimers Dement (Amst) (2021)
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4
Automated analysis of lexical features in Frontotemporal Degeneration
In: Cortex (2021)
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5
Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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7
Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium
In: Alzheimers Dement (2020)
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8
Automated analysis of lexical features in Frontotemporal Degeneration
In: medRxiv (2020)
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9
A Longitudinal Study of Speech Production in Primary Progressive Aphasia and Behavioral Variant Frontotemporal Dementia
In: Brain Lang (2019)
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10
Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia
Giannini, Lucia A.A.; Irwin, David J.; McMillan, Corey T.. - : Lippincott Williams & Wilkins, 2017
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11
Neural Correlates of Verbal Episodic Memory and Lexical Retrieval in Logopenic Variant Primary Progressive Aphasia
Win, Khaing T.; Pluta, John; Yushkevich, Paul. - : Frontiers Media S.A., 2017
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12
Transcranial direct current stimulation for the treatment of primary progressive aphasia: An open-label pilot study
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13
Beyond words: Pragmatic inference in behavioral variant of frontotemporal degeneration
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14
Processing ambiguity in a linguistic context: decision-making difficulties in non-aphasic patients with behavioral variant frontotemporal degeneration
Spotorno, Nicola; Healey, Meghan; McMillan, Corey T.. - : Frontiers Media S.A., 2015
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15
Action verb comprehension in amyotrophic lateral sclerosis and Parkinson’s disease
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16
Interrater reliability of the new criteria for behavioral variant frontotemporal dementia.
In: Neurology, vol 80, iss 21 (2013)
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17
Comparative semantic profiles in semantic dementia and Alzheimer's disease
Libon, David J.; Rascovsky, Katya; Powers, John. - : Oxford University Press, 2013
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18
Clinical diagnostic criteria and classification controversies in frontotemporal lobar degeneration
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19
Sparse canonical correlation analysis relates network-level atrophy to multivariate cognitive measures in a neurodegenerative population
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20
Differentiating primary progressive aphasias in a brief sample of connected speech
Ash, Sharon; Evans, Emily; O'Shea, Jessica. - : Lippincott Williams & Wilkins, 2013
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