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Primary Progressive Aphasia Associated With GRN Mutations: New Insights Into the Non-amyloid Logopenic Variant
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In: ISSN: 0028-3878 ; EISSN: 1526-632X ; Neurology ; https://hal.archives-ouvertes.fr/hal-03281660 ; Neurology, American Academy of Neurology, 2021, ⟨10.1212/wnl.0000000000012174⟩ (2021)
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The White Matter Module-Hub Network of Semantics Revealed by Semantic Dementia
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In: ISSN: 0898-929X ; EISSN: 1530-8898 ; Journal of Cognitive Neuroscience ; https://hal.inria.fr/hal-02554966 ; Journal of Cognitive Neuroscience, Massachusetts Institute of Technology Press (MIT Press), 2020, pp.1-18. ⟨10.1162/jocn_a_01549⟩ (2020)
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Abstract:
International audience ; 2AbstractCognitive neuroscience exploring the architecture of semantics has shown that coherent supra-modal concepts are computed in the anterior temporal lobes (ATL) but it is unknown how/where modularinformation implemented by posterior cortices (word/object/face forms) is conveyed to the ATL hub. We investigated the semantic module-hub network in healthy adults (N = 19) and in semantic dementia patients (N = 28) by combining semantic assessments of verbal and non-verbal stimuli and MRI-based fiber tracking usingseeds in three module-related cortices implementing i) written word forms (‘Visual Word Form Area’), ii) abstract lexical representations (posterior-superior temporal cortices), and iii) face/object representations (‘Face Form Area’).Fiber tracking revealed three key tracts linking the ATL with the three module-related cortices. Correlation analyses between tract parameters and semantic scores indicated that the three tracts subserve semantics, transferring modular verbal or non-verbal object/face information to the left and right ATL, respectively. The module-hub tracts were functionally and micro-structurally damaged in semantic dementia whereas damage to non-module specific ATL tracts (inferior longitudinal fasciculus, uncinate fasciculus) had more limited impact on semantic failure. These findings identify major components of the white matter module-hub network of semantics and they corroborate/materialize claims of cognitive models positing direct links between modular and semantic representations. In combination with modular accounts of cognition, they also suggest that the currently prevailing ‘hub-and-spokes’ model of semantics could be extended by incorporating an intermediate module level containing invariant representations, in addition to ‘spokes’ which subserve the processing of a near-unlimited number of sensori-motor and speech-sound features.
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Keyword:
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging; Diffusion MRI; Semantic dementia; Semantics; Tractograghy
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URL: https://hal.inria.fr/hal-02554966/file/Sundqvist-SemNetwork_Preprint.pdf
https://hal.inria.fr/hal-02554966/document
https://doi.org/10.1162/jocn_a_01549
https://hal.inria.fr/hal-02554966
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| 3 |
Sulcal morphology in Alzheimer's disease: an effective marker of diagnosis and cognition
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In: ISSN: 0197-4580 ; Neurobiology of Aging ; https://www.hal.inserm.fr/inserm-02266990 ; Neurobiology of Aging, Elsevier, 2019, Epub ahead of print. ⟨10.1016/j.neurobiolaging.2019.07.015⟩ (2019)
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| 4 |
Structural, Microstructural, and Metabolic Alterations in Primary Progressive Aphasia Variants
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In: ISSN: 1664-2295 ; Frontiers in Neurology ; https://hal.inria.fr/hal-01897015 ; Frontiers in Neurology, Frontiers, 2018, 9, ⟨10.3389/fneur.2018.00766⟩ (2018)
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| 5 |
The structure of the mental lexicon: what primary progressive aphasias reveal
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In: ISSN: 0028-3932 ; EISSN: 1873-3514 ; Neuropsychologia ; https://hal.inria.fr/hal-01672932 ; Neuropsychologia, Elsevier, 2018, 109, pp.107-115. ⟨10.1016/j.neuropsychologia.2017.12.018⟩ (2018)
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| 6 |
Structural, microstructural and metabolic alterations in Primary Progressive Aphasia variants
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In: Annual meeting of the Organization for Human Brain Mapping - OHBM 2018 ; https://hal.inria.fr/hal-01764289 ; Annual meeting of the Organization for Human Brain Mapping - OHBM 2018, Jun 2018, Singapore, Singapore (2018)
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An Automated Pipeline for the Analysis of PET Data on the Cortical Surface
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In: ISSN: 1662-5196 ; Frontiers in Neuroinformatics ; https://hal.inria.fr/hal-01950933 ; Frontiers in Neuroinformatics, Frontiers, 2018, 12, ⟨10.3389/fninf.2018.00094⟩ (2018)
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An Automated Pipeline for the Analysis of PET Data on the Cortical Surface
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| 9 |
Structural, Microstructural, and Metabolic Alterations in Primary Progressive Aphasia Variants
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| 10 |
Accuracy of MRI classification algorithms in a tertiary memory center clinical routine cohort
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In: AAIC 2017 - Alzheimer's Association International Conference ; https://hal.archives-ouvertes.fr/hal-02192444 ; AAIC 2017 - Alzheimer's Association International Conference, Jul 2017, London, United Kingdom. pp.P772-P774, ⟨10.1016/j.jalz.2017.06.1034⟩ (2017)
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| 11 |
Improved accuracy of the diagnosis of early Alzheimer’s disease using combined measures of hippocampal volume and sulcal morphology
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In: AAN 2014 - Annual Meeting of the American Academy of Neurology ; https://hal.inria.fr/hal-01114138 ; AAN 2014 - Annual Meeting of the American Academy of Neurology, Apr 2014, Philadelphia, United States (2014)
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