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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 3 4 5...9 Hits 1 – 20 of 170 1 Cortical microstructure in primary progressive aphasia: a multicenter study. Illán-Gala, Ignacio; Montal, Victor; Borrego-Écija, Sergi... In: Alzheimer's research & therapy, vol 14, iss 1 (2022) BASE Show details 2 Neuroanatomical correlations of visuospatial processing in primary progressive aphasia Tee, Boon Lead; Watson Pereira, Christa; Lukic, Sladjana... In: Brain Commun (2022) BASE Show details 3 Editorial: The Unusual Suspects: Linguistic Deficits in Non-Language-Dominant Neurodegenerative Diseases García, Adolfo M.; Ibáñez, Agustín; Miller, Bruce... In: Front Aging Neurosci (2022) BASE Show details 4 Primary Progressive Aphasia Associated With GRN Mutations: New Insights Into the Non-amyloid Logopenic Variant Saracino, Dario; Ferrieux, Sophie; NOGUES-LASSIAILLE, Marie; Houot, Marion; FUNKIEWIEZ, Aurelie; Sellami, Leila; Deramecourt, Vincent; Pasquier, Florence; Couratier, Philippe; PARIENTE, Jeremie; GERAUDIE, Amandine; Epelbaum, Stephane; Wallon, David; Hannequin, Didier; Martinaud, Olivier; Clot, Fabienne; CAMUZAT, Agnes; Bottani, Simona; Rinaldi, Daisy; Auriacombe, Sophie; Sarazin, Marie; Didic, Mira; Boutoleau-Bretonnière, Claire; Thauvin-Robinet, Christel; Lagarde, Julien; ROUE-JAGOT, Carole; SELLAL, Francois; Gabelle, Audrey; ETCHARRY-BOUYX, Frederique; Morin, Alexandre; COPPOLA, Cinzia; Levy, Richard; Dubois, Bruno; Brice, Alexis; Colliot, Olivier; GORNO-TEMPINI, Maria Luisa; Teichmann, Marc; Migliaccio, Raffaella; Le Ber, Isabelle; FRENCH RESEARCH NETWORK ON, Ftd Ftd-Als In: ISSN: 0028-3878 ; EISSN: 1526-632X ; Neurology ; https://hal.archives-ouvertes.fr/hal-03281660 ; Neurology, American Academy of Neurology, 2021, ⟨10.1212/wnl.0000000000012174⟩ (2021) Abstract: International audience ; OBJECTIVE: To determine relative frequencies and linguistic profiles of primary progressive aphasia (PPA) variants associated with progranulin (GRN) mutations, and study their neuroanatomical correlates. METHODS: PPA patients carrying GRN mutations (PPA-GRN) were selected amongst a national prospective research cohort of 1,696 frontotemporal dementia (FTD) patients, including 235 patients with PPA. All PPA patients with amyloid-positive CSF biomarkers were excluded. In this cross-sectional study, speech/language and cognitive profiles were characterized with standardized evaluations, and grey matter (GM) atrophy patterns using voxel-based morphometry. Comparisons were performed with controls, and sporadic PPA patients. RESULTS: Among the overall population of 235 patients, 45 (19%) carried GRN mutations. We studied 32 of these and showed that logopenic PPA (lvPPA) was the most frequent linguistic variant (13, 41%), followed by non-fluent/agrammatic (nfvPPA: 9, 28%) and mixed forms (8, 25%). Semantic variant was rather rare (2, 6%). LvPPA patients, qualified as non-amyloid-lvPPA, presented canonical logopenic deficit. Seven out of 13 had a pure form, six showed subtle additional linguistic deficits not fitting criteria for mixed PPA, hence labelled as "logopenic-spectrum variant". GM atrophy primarily involved left posterior temporal gyrus, mirroring neuroanatomical changes of amyloid-positive-lvPPA. NfvPPA patients presented agrammatism (89%) rather than apraxia of speech (11%). CONCLUSIONS: This study shows that most frequent PPA variant associated with GRN mutations is non-amyloid lvPPA, preceding nfvPPA and mixed forms, and illustrates that language network may be affected at different levels. GRN testing is indicated for PPA patients, whether familial or sporadic. This finding is important for upcoming GRN gene-specific therapies. Keyword: [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; Dementia aphasia; Frontotemporal dementia URL: https://hal.archives-ouvertes.fr/hal-03281660/document https://hal.archives-ouvertes.fr/hal-03281660/file/NEUROLOGY-2020-153064v3-LeBer.pdf https://hal.archives-ouvertes.fr/hal-03281660 https://doi.org/10.1212/wnl.0000000000012174 BASE Hide details 5 Uniform data set language measures for bvFTD and PPA diagnosis and monitoring. Staffaroni, Adam M; Weintraub, Sandra; Rascovsky, Katya... In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021) BASE Show details 6 Uniform data set language measures for bvFTD and PPA diagnosis and monitoring. Staffaroni, Adam M; Weintraub, Sandra; Rascovsky, Katya... In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021) BASE Show details 7 Speech Metrics and Samples That Differentiate Between Nonfluent/Agrammatic and Logopenic Variants of Primary Progressive Aphasia Haley, Katarina L.; Jacks, Adam; Jarrett, Jordan... In: J Speech Lang Hear Res (2021) BASE Show details 8 Treatment for Anomia in Bilingual Speakers with Progressive Aphasia Grasso, Stephanie M.; Peña, Elizabeth D.; Kazemi, Nina... In: Brain Sci (2021) BASE Show details 9 Cortical Tracking of the Speech Envelope in Logopenic Variant Primary Progressive Aphasia Dial, Heather R.; Gnanateja, G. Nike; Tessmer, Rachel S.... In: Front Hum Neurosci (2021) BASE Show details 10 Uniform data set language measures for bvFTD and PPA diagnosis and monitoring Staffaroni, Adam M.; Weintraub, Sandra; Rascovsky, Katya... In: Alzheimers Dement (Amst) (2021) BASE Show details 11 Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET La Joie, Renaud; Visani, Adrienne V.; Lesman-Segev, Orit H.... In: Neurology (2021) BASE Show details 12 Connected speech markers of amyloid burden in primary progressive aphasia Slegers, Antoine; Chafouleas, Geneviève; Montembeault, Maxime. - : Elsevier, 2021 BASE Show details 13 Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example Europa, Eduardo; Iaccarino, Leonardo; Perry, David C. - : eScholarship, University of California, 2020 BASE Show details 14 Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease. Chapleau, Marianne; Bedetti, Christophe; Devenyi, Gabriel A. - : eScholarship, University of California, 2020 BASE Show details 15 Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease. Chapleau, Marianne; Bedetti, Christophe; Devenyi, Gabriel A. - : eScholarship, University of California, 2020 BASE Show details 16 Data-Driven, Visual Framework for the Characterization of Aphasias Across Stroke, Post-resective, and Neurodegenerative Disorders Over Time. Fan, Joline M; Gorno-Tempini, Maria Luisa; Dronkers, Nina F. - : eScholarship, University of California, 2020 BASE Show details 17 Speech and language therapy approaches to managing primary progressive aphasia Volkmer, Anna; Rogalski, Emily; Henry, Maya. - : BMJ Publishing Group Ltd, 2020 BASE Show details 18 PPA diagnosis (Europa et al., 2020) ... Europa, Eduardo; Iaccarino, Leonardo; Perry, David C.. - : ASHA journals, 2020 BASE Show details 19 PPA diagnosis (Europa et al., 2020) ... Europa, Eduardo; Iaccarino, Leonardo; Perry, David C.. - : ASHA journals, 2020 BASE Show details 20 Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates ... Vinceti, Giulia; Olney, Nicholas; Mandelli, Maria Luisa. - : Taylor & Francis, 2020 BASE Show details Page: 1 2 3 4 5...9

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