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1
Does Cue Focality Modulate Age-related Performance in Prospective Memory? An fMRI Investigation
Carlesimo, G; Santangelo, V; Barban, F. - : TAYLOR & FRANCIS INC, 2021
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2
Effects of palmitoylethanolamide combined with luteoline on frontal lobe functions, high frequency oscillations, and GABAergic transmission in patients with frontotemporal dementia
Abstract: Background: Frontotemporal dementia (FTD) is a presenile neurodegenerative disease for which there is no effective pharmacological treatment. Recently, a link has been proposed between neuroinflammation and FTD. Objective: Here, we aim to investigate the effects of palmitoylethanolamide (PEA) combined with luteoline (PEA-LUT), an endocannabinoid with anti-inflammatory and neuroprotective effects, on behavior, cognition, and cortical activity in a sample of FTD patients. Methods: Seventeen patients with a diagnosis of probable FTD were enrolled. Cognitive and neurophysiological evaluations were performed at baseline and after 4 weeks of PEA-LUT 700 mg×2/day. Cognitive effects were assessed by Neuropsychiatric Inventory (NPI), Mini-Mental State Examination, Frontal Assessment Battery (FAB), Screening for Aphasia in Neurodegeneration, Activities of Daily Living-Instrumental Activities of Daily Living, and Frontotemporal Lobar Degeneration-modified Clinical Dementia Rating scale. To investigate in vivo neurophysiological effects of PEA-LUT, we used repetitive and paired-pulse transcranial magnetic stimulation (TMS) protocols assessing LTP-like cortical plasticity, short-interval intracortical inhibition, long-interval intracortical inhibition (LICI), and short-latency afferent inhibition. Moreover, we used TMS combined with EEG to evaluate the effects on frontal lobe cortical oscillatory activity. Results: Treatment with PEA-LUT was associated with an improvement in NPI and FAB scores. Neurophysiological evaluation showed a restoration of LICI, in particular at ISI 100 ms, suggesting a modulation of GABA(B) activity. TMS-EEG showed a remarkable increase of TMS-evoked frontal lobe activity and of high-frequency oscillations in the beta/gamma range. Conclusion: PEA-LUT could reduce behavioral disturbances and improve frontal lobe functions in FTD patients through the modulation of cortical oscillatory activity and GABA(B)ergic transmission. Keywords: Brain inflammation; EEG; GABA activity; behavioral symptoms; executive functions; frontotemporal dementia; transcranial magnetic stimulation.
Keyword: Settore MED/26
URL: http://hdl.handle.net/2108/252831
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3
Associative agreement as a predictor of naming ability in alzheimer’s disease: A case for the semantic nature of associative links
Zannino, GD; Perri, R; Teghil, A. - : FRONTIERS MEDIA SA, 2018
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4
Transcranial cerebellar direct current stimulation enhances verb generation but not verb naming in poststroke Aphasia
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5
Does Dopamine Depletion Trigger a Spreader Lexical-Semantic Activation in Parkinson's Disease? Evidence from a Study Based on Word Fluency Tasks
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6
Moving beyond the brain: Transcutaneous spinal direct current stimulation in post-stroke aphasia
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7
Does dopamine depletion trigger a spreader lexical-semantic activation in Parkinson’s disease? Evidence from a study based on word fluency tasks.
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8
Right sensory-motor functional networks subserve action observation therapy in aphasia
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9
Bilateral transcranial direct current stimulation language treatment enhances functional connectivity in the left hemisphere: Preliminary data from aphasia
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10
Role of the anterior temporal lobes in semantic representations: Paradoxical results of a cTBS study
Bonni, S.; Koch, G.; Miniussi, C.. - : Elsevier Ltd, 2015
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11
Combining TMS-EEG with transcranial direct current stimulation language treatment in aphasia
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12
Processing past tense in the left cerebellum
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13
Bihemispheric tDCS enhances language recovery but does not alter BDNF levels in chronic aphasic patients
Fiori, V; Caltagirone, C; Marangolo, P. - : IOS Press, 2014
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14
Effect of levodopa on both verbal and motor representations of action in Parkinson’s disease: A fMRI study
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 125 (2013) 3, 324-329
OLC Linguistik
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15
Effect of levodopa on both verbal and motor representations of action in Parkinson's disease: a fMRI study.
In: Brain and Language, vol. 125, no. 3, pp. 324-329 (2013)
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16
Forward and backward span for verbal and visuo-spatial data: standardization and normative data from an Italian adult population
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17
tDCS over the left inferior frontal cortex improves speech production in aphasia
Razzano, C; Campana, S; Marangolo, P. - : Frontiers Research Foundation, 2013
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18
Options to enhance recovery from aphasia by means of non-invasive brain stimulation and action observation therapy
Caltagirone, C; Marangolo, P. - : Expert Reviews Ltd, 2013
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19
Something to talk about: Enhancement of linguistic cohesion through tdCS in chronic non fluent aphasia
Marangolo, P; Fiori, V; Campana, S. - : Elsevier Science Limited, 2013
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20
tDCS stimulation segregates words in the brain: evidence from aphasia
Razzano, C; Cipollari, S; Marangolo, P. - : Frontiers Research Foundation, 2013
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