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1
Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
Shdo, Suzanne M; Ranasinghe, Kamalini G; Sturm, Virginia E. - : eScholarship, University of California, 2020
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Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
Shdo, Suzanne M; Ranasinghe, Kamalini G; Sturm, Virginia E. - : eScholarship, University of California, 2020
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3
Taking the sublexical route: brain dynamics of reading in the semantic variant of primary progressive aphasia
In: Brain (2020)
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4
Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages
In: Front Neurol (2020)
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5
Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
In: Toller, Gianina; Yang, Winson FZ; Brown, Jesse A; Ranasinghe, Kamalini G; Shdo, Suzanne M; Kramer, Joel H; et al.(2019). Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity. NeuroImage. Clinical, 22, 101729. doi:10.1016/j.nicl.2019.101729. UCSF: Retrieved from: http://www.escholarship.org/uc/item/9qm527cr (2019)
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6
Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
Abstract: Loss of warmth is well-documented in behavioral variant frontotemporal dementia (bvFTD) and semantic variant primary progressive aphasia (svPPA) at a group level, and has been linked to salience (SN) and semantic-appraisal (SAN) network atrophy. However, clinical observations of individual patients show much greater heterogeneity, thus measuring this clinical variability and identifying the underlying neurologic mechanisms is a critical step for understanding the symptom profile of any one patient. We used reliable change indexes with premorbid and current informant-based evaluations to characterize patterns of change on the warmth subscale of the Interpersonal Adjective Scale (IAS) questionnaire in 132 patients (21 bvFTD, 19 svPPA, 22 nonfluent variant primary progressive aphasia [nfvPPA], 37 Alzheimer's disease [AD]) and 33 healthy older adults. We investigated whether individual differences in warmth change were reflected in SN or SAN functional connectivity, or structural volume of individual brain regions in these two networks. Though one subset of patients showed significant drop in warmth to abnormally low levels (bvFTD: 38%; svPPA: 21%; nfvPPA: 5%; AD: 11%), a second subset significantly dropped but remained within the clinically normal range (bvFTD: 33%; svPPA: 21%; nfvPPA: 9%; AD: 5%), and a third subset did not drop and stayed in the clinically normal range (bvFTD: 29%; svPPA: 58%; nfvPPA: 86%; AD: 84%). Furthermore, interpersonal warmth score was strongly predicted by SN functional connectivity (p < .01), but not by SAN functional connectivity or by structural volume in these networks. Our results extend earlier group-level findings by showing wide individual variability in degree of disease-related reduction of interpersonal warmth and SN functional connectivity in bvFTD and svPPA, and highlight new approaches to revealing how brain connectivity predicts behavior on an individual patient level. Our findings suggest that measures of interpersonal warmth can provide important clinical information about changes in underlying brain networks, and help clinicians and clinical researchers better identify which bvFTD and svPPA patients are at greater risk for interpersonal disruption.
Keyword: 2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aged; Aging; Alzheimer's Disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Behavioral variant frontotemporal dementia; Brain Disorders; Clinical Research; Dementia; Female; Frontotemporal Dementia; Frontotemporal Dementia (FTD); Humans; Interpersonal warmth; Male; Middle Aged; Nerve Net; Neurodegenerative; Neurological; Neurosciences; Predictive Value of Tests; Resting-state fMRI; Salience network; Semantic variant primary progressive aphasia; Semantic-appraisal network; Social Skills
URL: https://escholarship.org/uc/item/9qm527cr
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7
Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
Toller, Gianina; Yang, Winson FZ; Brown, Jesse A. - : eScholarship, University of California, 2019
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8
Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.
In: Ranasinghe, Kamalini G; Kothare, Hardik; Kort, Naomi; Hinkley, Leighton B; Beagle, Alexander J; Mizuiri, Danielle; et al.(2019). Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease. Scientific reports, 9(1), 5686. doi:10.1038/s41598-019-41794-x. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3170w5cs (2019)
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9
Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.
In: Scientific reports, vol 9, iss 1 (2019)
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10
Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.
In: Scientific reports, vol 9, iss 1 (2019)
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11
Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity
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12
Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer’s disease
Ranasinghe, Kamalini G.; Kothare, Hardik; Kort, Naomi. - : Nature Publishing Group UK, 2019
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13
Distinct spatiotemporal patterns of neuronal functional connectivity in primary progressive aphasia variants
Ranasinghe, Kamalini G; Hinkley, Leighton B; Beagle, Alexander J. - : Oxford University Press, 2017
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14
Deconstructing empathy: Neuroanatomical dissociations between affect sharing and prosocial motivation using a patient lesion model
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15
Regional functional connectivity predicts distinct cognitive impairments in Alzheimer’s disease spectrum
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16
Discrimination of brief speech sounds is impaired in rats with auditory cortex lesions
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