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Effect of age on rate and coarticulation across different speech-tasks.
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In: 12th International Seminar on Speech Production ; https://hal.archives-ouvertes.fr/hal-03099438 ; 12th International Seminar on Speech Production, Dec 2020, Providence, United States (2020)
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Have a break: Aging effects on sentence production and structuring in French
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In: 12th International Seminar on Speech Production ; https://halshs.archives-ouvertes.fr/halshs-03083581 ; 12th International Seminar on Speech Production, Dec 2020, virtual, United States (2020)
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Débit et réduction vocalique : effets de la tâche de parole et du locuteur
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In: Actes de la 6e conférence conjointe Journées d'Études sur la Parole (JEP, 33e édition), Traitement Automatique des Langues Naturelles (TALN, 27e édition), Rencontre des Étudiants Chercheurs en Informatique pour le Traitement Automatique des Langues (RÉCITAL, 22e édition). Volume 1 : Journées d'Études sur la Parole ; 6e conférence conjointe Journées d'Études sur la Parole (JEP, 33e édition), Traitement Automatique des Langues Naturelles (TALN, 27e édition), Rencontre des Étudiants Chercheurs en Informatique pour le Traitement Automatique des Langues (RÉCITAL, 22e édition). Volume 1 : Journées d'Études sur la Parole ; https://hal.archives-ouvertes.fr/hal-02798513 ; 6e conférence conjointe Journées d'Études sur la Parole (JEP, 33e édition), Traitement Automatique des Langues Naturelles (TALN, 27e édition), Rencontre des Étudiants Chercheurs en Informatique pour le Traitement Automatique des Langues (RÉCITAL, 22e édition). Volume 1 : Journées d'Études sur la Parole, 2020, Nancy, France. pp.45-53 (2020)
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Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial
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Sanches, Clara; Levy, Richard; Benisty, Sarah; Volpe-Gillot, Lisette; Habert, Marie-Odile; Kas, Aurélie; Ströer, Sébastian; Pyatigorskaya, Nadya; Kaglik, Anna; Bourbon, Angelina; Dubois, Bruno; Migliaccio, Raffaella; Valero-Cabré, Antoni; Teichmann, Marc
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In: ISSN: 1745-6215 ; Trials ; https://hal.sorbonne-universite.fr/hal-02407657 ; Trials, BioMed Central, 2019, 20 (1), pp.632. ⟨10.1186/s13063-019-3613-z⟩ (2019)
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Abstract:
International audience ; BACKGROUND: Semantic dementia is a neurodegenerative disease that primarily affects the left anterior temporal lobe, resulting in a gradual loss of conceptual knowledge. There is currently no validated treatment. Transcranial stimulation has provided evidence for long-lasting language effects presumably linked to stimulation-induced neuroplasticity in post-stroke aphasia. However, studies evaluating its effects in neurodegenerative diseases such as semantic dementia are still rare and evidence from double-blind, prospective, therapeutic trials is required.OBJECTIVE: The primary objective of the present clinical trial (STIM-SD) is to evaluate the therapeutic efficacy of a multiday transcranial direct current stimulation (tDCS) regime on language impairment in patients with semantic dementia. The study also explores the time course of potential tDCS-driven improvements and uses imaging biomarkers that could reflect stimulation-induced neuroplasticity.METHODS: This is a double-blind, sham-controlled, randomized study using transcranial Direct Current Stimulation (tDCS) applied daily for 10 days, and language/semantic and imaging assessments at four time points: baseline, 3 days, 2 weeks and 4 months after 10 stimulation sessions. Language/semantic assessments will be carried out at these same 4 time points. Fluorodeoxyglucose positron emission tomography (FDG-PET), resting-state functional magnetic resonance imaging (rs-fMRI), T1-weighted images and white matter diffusion tensor imaging (DTI) will be applied at baseline and at the 2-week time point. According to the principle of inter-hemispheric inhibition between left (language-related) and right homotopic regions we will use two stimulation modalities - left-anodal and right-cathodal tDCS over the anterior temporal lobes. Accordingly, the patient population (n = 60) will be subdivided into three subgroups: left-anodal tDCS (n = 20), right-cathodal tDCS (n = 20) and sham tDCS (n = 20). The stimulation will be sustained for 20 min at an intensity of 1.59 mA. It will be delivered through 25cm2-round stimulation electrodes (current density of 0.06 mA/cm2) placed over the left and right anterior temporal lobes for anodal and cathodal stimulation, respectively. A group of healthy participants (n = 20) matched by age, gender and education will also be recruited and tested to provide normative values for the language/semantic tasks and imaging measures.DISCUSSION: The aim of this study is to assess the efficacy of tDCS for language/semantic disorders in semantic dementia. A potential treatment would be easily applicable, inexpensive, and renewable when therapeutic effects disappear due to disease progression.
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Keyword:
[SDV.IB]Life Sciences [q-bio]/Bioengineering; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology; [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]; Language impairments; Neurodegenerative diseases; Neurology; Non-invasive brain stimulation; Primary progressive aphasia; Semantic dementia; Transcranial direct current stimulation
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URL: https://doi.org/10.1186/s13063-019-3613-z
https://hal.sorbonne-universite.fr/hal-02407657
https://hal.sorbonne-universite.fr/hal-02407657/file/document%281%29.pdf
https://hal.sorbonne-universite.fr/hal-02407657/document
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Age effects on voice and rate in French according to sex
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In: 1st International Seminar on the Foundations of Speech (SEFOS): Breathing, Pausing, and the Voice ; https://hal.archives-ouvertes.fr/hal-02434380 ; 1st International Seminar on the Foundations of Speech (SEFOS): Breathing, Pausing, and the Voice, Dec 2019, Sonderborg, Denmark (2019)
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Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial ...
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Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial ...
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Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial
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Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial
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