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Extremely preterm children demonstrate hyperconnectivity during verb generation: A multimodal approach
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In: Neuroimage Clin (2021)
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Diffuse white matter abnormality in very preterm infants at term reflects reduced brain network efficiency
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In: Neuroimage Clin (2021)
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Early cortical maturation predicts neurodevelopment in very preterm infants
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Abstract:
Objective To evaluate the ability of four objectively defined, cortical maturation features—surface area, gyrification index, sulcal depth and curvature—from structural MRI at term-equivalent age (TEA) to independently predict cognitive and language development at 2 years corrected age in very preterm (VPT) infants. Design Population-based, prospective cohort study. Structural brain MRI was performed at term, between 40 and 44 weeks postmenstrual age and processed using the developing Human Connectome Project pipeline. Setting Multicentre study comprising four regional level III neonatal intensive care units in the Columbus, Ohio region. Patients 110 VPT infants (gestational age (GA) 31 weeks). Main outcome measures Cognitive and language scores at 2 years corrected age on the Bayley Scales of Infant and Toddler Development, Third Edition. Results Of the 94 VPT infants with high-quality T2-weighted MRI scans, 75 infants (80%) returned for Bayley-III testing. Cortical surface area was positively correlated with cognitive and language scores in nearly every brain region. Curvature of the inner cortex was negatively correlated with Bayley scores in the frontal, parietal and temporal lobes. In multivariable regression models, adjusting for GA, sex, socioeconomic status, and injury score on MRI, regional measures of surface area and curvature independently explained more than one-third of the variance in cognitive and language scores at 2 years corrected age in our cohort. Conclusions We identified increased cortical curvature at TEA as a new prognostic biomarker of adverse neurodevelopment in very premature infants. When combined with cortical surface area, it enhanced prediction of cognitive and language development. Larger studies are needed to externally validate our findings.
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Original research
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URL: http://fn.bmj.com/cgi/content/short/105/5/460
https://doi.org/10.1136/archdischild-2019-317466
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Extremely Preterm Children Demonstrate Interhemispheric Hyperconnectivity During Verb Generation: a Multimodal Approach
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In: medRxiv (2020)
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Early cortical maturation predicts neurodevelopment in very preterm infants
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In: Arch Dis Child Fetal Neonatal Ed (2019)
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Magnetic Resonance Spectroscopy at Term-Equivalent Age in Extremely Preterm Infants: Association With Cognitive and Language Development
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