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Strategies and cognitive reserve to preserve lexical production in aging
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In: ISSN: 2509-2715 ; EISSN: 2509-2723 ; GeroScience ; https://hal.univ-grenoble-alpes.fr/hal-03253711 ; GeroScience, Springer International Publishing, 2021, ⟨10.1007/s11357-021-00367-5⟩ (2021)
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Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia
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Gialluisi, Alessandro; Andlauer, Till,; Mirza-Schreiber, Nazanin; Moll, Kristina; Becker, Jessica; Hoffmann, Per; Ludwig, Kerstin,; Czamara, Darina; Pourcain, Beate St; Honbolygó, Ferenc; Tóth, Dénes; Csépe, Valéria; Huguet, Guillaume; Chaix, Yves; Iannuzzi, Stephanie; Demonet, Jean-Francois; Morris, Andrew,; Hulslander, Jacqueline; Willcutt, Erik,; DeFries, John,; Olson, Richard,; Smith, Shelley,; Pennington, Bruce,; Vaessen, Anniek; Maurer, Urs; Lyytinen, Heikki; Peyrard-Janvid, Myriam; Leppänen, Paavo,; Brandeis, Daniel; Bonte, Milene; Stein, John,; Talcott, Joel,; Fauchereau, Fabien; Wilcke, Arndt; Kirsten, Holger; Müller, Bent; Francks, Clyde; Bourgeron, Thomas; Monaco, Anthony,; Ramus, Franck; Landerl, Karin; Kere, Juha; Scerri, Thomas,; Paracchini, Silvia; Fisher, Simon,; Schumacher, Johannes; Nöthen, Markus,; Müller-Myhsok, Bertram; Schulte-Körne, Gerd
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In: ISSN: 1359-4184 ; EISSN: 1476-5578 ; Molecular Psychiatry ; https://hal.archives-ouvertes.fr/hal-02976104 ; Molecular Psychiatry, Nature Publishing Group, 2020, ⟨10.1038/s41380-020-00898-x⟩ (2020)
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Abstract:
International audience ; Developmental dyslexia (DD) is a learning disorder affecting the ability to read, with a heritability of 40–60%. A notable part of this heritability remains unexplained, and large genetic studies are warranted to identify new susceptibility genes and clarify the genetic bases of dyslexia. We carried out a genome-wide association study (GWAS) on 2274 dyslexia cases and 6272 controls, testing associations at the single variant, gene, and pathway level, and estimating heritability using single-nucleotide polymorphism (SNP) data. We also calculated polygenic scores (PGSs) based on large-scale GWAS data for different neuropsychiatric disorders and cortical brain measures, educational attainment, and fluid intelligence, testing them for association with dyslexia status in our sample. We observed statistically significant (p < 2.8 × 10−6) enrichment of associations at the gene level, for LOC388780 (20p13; uncharacterized gene), and for VEPH1 (3q25), a gene implicated in brain development. We estimated an SNP-based heritability of 20–25% for DD, and observed significant associations of dyslexia risk with PGSs for attention deficit hyperactivity disorder (at pT = 0.05 in the training GWAS: OR = 1.23[1.16; 1.30] per standard deviation increase; p = 8 × 10−13), bipolar disorder (1.53[1.44; 1.63]; p = 1 × 10−43), schizophrenia (1.36[1.28; 1.45]; p = 4 × 10−22), psychiatric cross-disorder susceptibility (1.23[1.16; 1.30]; p = 3 × 10−12), cortical thickness of the transverse temporal gyrus (0.90[0.86; 0.96]; p = 5 × 10−4), educational attainment (0.86[0.82; 0.91]; p = 2 × 10−7), and intelligence (0.72[0.68; 0.76]; p = 9 × 10−29). This study suggests an important contribution of common genetic variants to dyslexia risk, and novel genomic overlaps with psychiatric conditions like bipolar disorder, schizophrenia, and cross-disorder susceptibility. Moreover, it revealed the presence of shared genetic foundations with a neural correlate previously implicated in dyslexia by neuroimaging evidence.
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Keyword:
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
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URL: https://hal.archives-ouvertes.fr/hal-02976104/file/MolPsy20.pdf
https://hal.archives-ouvertes.fr/hal-02976104/document
https://doi.org/10.1038/s41380-020-00898-x
https://hal.archives-ouvertes.fr/hal-02976104
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| 3 |
Effects of orthographic consistency and word length on the dynamics of written production in adults: psycholinguistic and rTMS experiments
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In: ISSN: 0922-4777 ; EISSN: 1573-0905 ; Reading and Writing ; https://hal.archives-ouvertes.fr/hal-03576271 ; Reading and Writing, Springer Verlag, 2019, 32 (1), pp.115-146. ⟨10.1007/s11145-017-9776-7⟩ (2019)
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| 4 |
Reproducibility of Brain Responses: High for Speech Perception, Low for Reading Difficulties
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In: Scientific Reports (2019)
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| 5 |
Reproducibility of Brain Responses: High for Speech Perception, Low for Reading Difficulties
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| 6 |
Effects of orthographic consistency and word length on the dynamics of written production in adults: psycholinguistic and rTMS experiments
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In: Reading and Writing, vol. 32, no. 1, pp. 115-146 (2019)
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| 8 |
How specialized are writing-specific brain regions? An fMRI study of writing, drawing and oral spelling
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In: ISSN: 0010-9452 ; Cortex ; https://hal.archives-ouvertes.fr/hal-01473913 ; Cortex, Elsevier, 2017, 88, pp.66-80. ⟨10.1016/j.cortex.2016.11.018⟩ (2017)
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| 9 |
Second language performances in elderly bilinguals and individuals with dementia: The role of L2 immersion
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| 10 |
Primary Progressive Aphasia in the Network of French Alzheimer Plan Memory Centers
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In: ISSN: 1387-2877 ; Journal of Alzheimer's Disease ; https://hal.archives-ouvertes.fr/hal-01824840 ; Journal of Alzheimer's Disease, IOS Press, 2016, 54 (4), pp.1459 - 1471. ⟨10.3233/JAD-160536⟩ (2016)
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| 11 |
Primary Progressive Aphasia in the Network of French Alzheimer Plan Memory Centers
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In: ISSN: 1387-2877 ; Journal of Alzheimer's Disease ; https://hal-univ-fcomte.archives-ouvertes.fr/hal-03630200 ; Journal of Alzheimer's Disease, IOS Press, 2016, 54 (4), pp.1459-1471. ⟨10.3233/JAD-160536⟩ (2016)
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| 12 |
Phonological skills, visual attention span, and visual stress in developmental dyslexia.
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In: ISSN: 0012-1649 ; Developmental Psychology ; https://hal.archives-ouvertes.fr/hal-01400569 ; Developmental Psychology, American Psychological Association, 2016, 52 (10), pp.1503 - 1516. ⟨10.1037/dev0000184⟩ (2016)
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| 13 |
Particularités du variant logopénique au sein des aphasies progressives primaires
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In: ISSN: 0035-3787 ; Revue Neurologique ; https://hal.archives-ouvertes.fr/hal-01676814 ; Revue Neurologique, Elsevier Masson, 2015, 171 (1), pp.16 - 30. ⟨10.1016/j.neurol.2014.08.004⟩ (2015)
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| 14 |
Dyslexia in a French-Spanish bilingual girl: Behavioural and neural modulations following a visual attention span intervention.
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In: ISSN: 0010-9452 ; Cortex ; https://hal.archives-ouvertes.fr/hal-00965217 ; Cortex, Elsevier, 2014, 53, pp.120-145. ⟨10.1016/j.cortex.2013.11.006⟩ (2014)
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| 16 |
Predictors of developmental dyslexia in European orthographies with varying complexity.
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In: ISSN: 0021-9630 ; EISSN: 1469-7610 ; Journal of Child Psychology and Psychiatry ; https://hal.archives-ouvertes.fr/hal-00965034 ; Journal of Child Psychology and Psychiatry, Wiley, 2013, 54 (6), pp.686-94. ⟨10.1111/jcpp.12029⟩ (2013)
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| 17 |
Segregation of lexical and sub-lexical reading processes in the left perisylvian cortex.
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In: ISSN: 1932-6203 ; EISSN: 1932-6203 ; PLoS ONE ; https://hal.archives-ouvertes.fr/hal-00777284 ; PLoS ONE, Public Library of Science, 2012, 7 (11), pp.e50665. ⟨10.1371/journal.pone.0050665⟩ (2012)
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| 18 |
Effect of orthographic processes on letter identity and letter-position encoding in dyslexic children.
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In: EISSN: 1664-1078 ; Frontiers in Psychology ; https://hal.archives-ouvertes.fr/hal-00965206 ; Frontiers in Psychology, Frontiers, 2012, 3, pp.154. ⟨10.3389/fpsyg.2012.00154⟩ (2012)
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| 19 |
Neural dissociation of phonological and visual attention span disorders in developmental dyslexia: FMRI evidence from two case reports.
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In: ISSN: 0093-934X ; EISSN: 1090-2155 ; Brain and Language ; https://hal.archives-ouvertes.fr/hal-00798603 ; Brain and Language, Elsevier, 2012, 120 (3), pp.381-94. ⟨10.1016/j.bandl.2011.12.015⟩ (2012)
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| 20 |
Neuropsychological outcome after a first symptomatic ischaemic stroke with 'good recovery'
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In: ISSN: 1351-5101 ; EISSN: 1468-1331 ; European Journal of Neurology ; https://hal.archives-ouvertes.fr/hal-00667241 ; European Journal of Neurology, Wiley, 2012, 19 (2), pp.212-219. ⟨10.1111/j.1468-1331.2011.03450.x⟩ (2012)
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