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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 3 Hits 1 – 20 of 45 1 Shared storybook reading with children at family risk of dyslexia Hamilton, Lorna G.; Hayiou-Thomas, Marianna E.; Snowling, Margaret J.. - 2021 BASE Show details 2 Shared storybook reading with children at family risk of dyslexia Hamilton, Lorna G.; Hayiou‐Thomas, Marianna E.; Snowling, Margaret J. In: J Res Read (2021) BASE Show details 3 Polygenic scores and risk prediction for delay (Dale et al., 2020) ... Dale, Philip S.; Stumm, Sophie Von; Selzam, Saskia. - : ASHA journals, 2020 BASE Show details 4 Polygenic scores and risk prediction for delay (Dale et al., 2020) ... Dale, Philip S.; Stumm, Sophie Von; Selzam, Saskia. - : ASHA journals, 2020 BASE Show details 5 Does the Inclusion of a Genome-Wide Polygenic Score Improve Early Risk Prediction for Later Language and Literacy Delay? Dale, Philip S; von Stumm, Sophie; Selzam, Saskia; Hayiou-Thomas, Marianna E. - 2020 Abstract: Purpose The ability to identify children early in development who are at substantial risk for language/literacy difficulties would have great benefit both for the children and for the educational and therapeutic institutions that serve them. Information that is relatively easily available prior to the age of 3 years, such as late talking, family history of language/literacy difficulties, and socioeconomic status, have some but very limited predictive power. Here, we examine whether the inclusion of a DNA-based genome-wide polygenic score that has been shown to capture children's genetic propensity for educational attainment (EA3) adds enough prediction to yield a clinically useful score. Method Data are longitudinal scores of 1,420 children from the Twins Early Development Study, who were assessed at ages 2 and 3 years on language and nonverbal ability and at 12 years of age on oral language, word decoding, and reading comprehension. Five risk factors were examined: expressive vocabulary, nonverbal ability (these two from parent report), family history, mothers' education, and EA3. Analyses were conducted both for continuous and categorically defined measures of risk and outcome. Results Language and literacy abilities at 12 years of age were significantly but modestly predicted by the risk factors, with a small but significant added prediction from EA3. Indices of diagnostic validity for poor outcomes, such as sensitivity and area under the curve statistics, were poor in all cases. Conclusions We conclude that, at present, clinically useful prediction from toddlerhood remains an unattained goal. Supplemental Material https://doi.org/10.23641/asha.12170331. URL: https://eprints.whiterose.ac.uk/161112/ https://eprints.whiterose.ac.uk/161112/1/Polygenic_prediction_of_language_and_literacy_outcomes_Final_author_version.docx https://doi.org/10.1044/2020_JSLHR-19-00161 BASE Hide details 6 Does the Inclusion of a Genome-Wide Polygenic Score Improve Early Risk Prediction for Later Language and Literacy Delay? Dale, Philip S.; von Stumm, Sophie; Selzam, Saskia... In: J Speech Lang Hear Res (2020) BASE Show details 7 Dyslexia and Developmental Language Disorder : comorbid disorders with distinct effects on reading comprehension Snowling, Margaret J; Hayiou-Thomas, Marianna E; Nash, Hannah M. - 2019 BASE Show details 8 Developmental Outcomes for Children at High Risk of Dyslexia and Children With Developmental Language Disorder Snowling, Margaret J.; Nash, Hannah M.; Gooch, Debbie C.. - : John Wiley and Sons Inc., 2019 BASE Show details 9 Dyslexia and Developmental Language Disorder: comorbid disorders with distinct effects on reading comprehension Snowling, Margaret J.; Hayiou‐Thomas, Marianna E.; Nash, Hannah M.... In: J Child Psychol Psychiatry (2019) BASE Show details 10 Developmental Outcomes for Children at High Risk of Dyslexia and Children with Developmental Language Disorder Snowling, Maggie; Nash, Hannah M; Gooch, Debbie. - : Wiley, 2019 BASE Show details 11 Developmental dyslexia Hayiou-Thomas, Marianna E.; Carroll, Julia M.; Snowling, Margaret J. In: The Oxford handbook of psycholinguistics (Oxford, 2018), p. 784-813 MPI für Psycholinguistik Show details 12 Grammar Clinical Marker Yields Substantial Heritability for Language Impairments in 16-Year-Old Twins Dale, Philip S.; Rice, Mabel L; Rimfeld, Kaili. - 2018 BASE Show details 13 The genetic architecture of oral language, reading fluency, and reading comprehension : A twin study from 7 to 16 years Tosto, Maria G.; Hayiou-Thomas, Marianna E.; Harlaar, Nicole. - 2017 BASE Show details 14 The Genetic Architecture of Oral Language, Reading Fluency, and Reading Comprehension: A Twin Study From 7 to 16 Years Tosto, Maria G.; Hayiou-Thomas, Marianna E.; Harlaar, Nicole. - : American Psychological Association, 2017 BASE Show details 15 Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes Pettigrew, Kerry Andrea; Frinton, Emily; Nudel, Ron. - 2016 BASE Show details 16 Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes Pettigrew, Kerry A.; Frinton, Emily; Nudel, Ron. - 2016 BASE Show details 17 Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes Pettigrew, Kerry A.; Frinton, Emily; Nudel, Ron. - : BioMed Central Ltd., 2016 BASE Show details 18 Copy Number Variation Screen Identifies a Rare De Novo Deletion at Chromosome 15q13.1-13.3 in a Child with Language Impairment Pettigrew, Kerry A.; Reeves, Emily; Leavett, Ruth. - : Public Library of Science, 2015 BASE Show details 19 Copy number variation screen identifies a rare de novo deletion at chromosome 15q13.1-13.3 in a child with language impairment Pettigrew, Kerry A.; Reeves, Emily; Leavett, Ruth. - 2015 BASE Show details 20 Why does parental language input style predict child language development? A twin study of gene–environment correlation Dale, Philip S.; Tosto, Maria Grazia; Hayiou-Thomas, Marianna E.. - : Elsevier Scientific Publishing, 2015 BASE Show details Page: 1 2 3

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