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Potential of automatic speech processing technologies for early detection of oral language disorders: a meta-analytic review ...
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Neurodevelopmental outcomes among extremely premature infants with linear growth restriction.
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Next-gen sequencing identifies non-coding variation disrupting miRNA-binding sites in neurological disorders
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Parenting Stress and Language Development in Children: Associations in Angelman Syndrome and Down Syndrome
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In: The Journal of Purdue Undergraduate Research (2021)
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Implicit Learning in Preschoolers with and Without Developmental Language Disorder
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In: Student Research Symposium (2021)
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Perfil linguístico de crianças com histórico de prematuridade: um estudo preliminar ; Linguistic profile of children with a history of prematurity: a preliminary study
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Expressive language development in adolescents with Down syndrome and fragile X syndrome: change over time and the role of family-related factors.
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In: Journal of neurodevelopmental disorders, vol 12, iss 1 (2020)
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Screen time in 36-month-olds at increased likelihood for ASD and ADHD.
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Screen time in 36-month-olds at increased likelihood for ASD and ADHD.
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A Distinction Between Linguistic and Social Pragmatics Helps the Precise Characterization of Pragmatic Challenges in Children With Autism Spectrum Disorders and Developmental Language Disorder. ...
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Health comorbidities and cognitive abilities across the lifespan in Down syndrome. ...
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Play and prosociality are associated with fewer externalizing problems in children with developmental language disorder: The role of early language and communication environment. ...
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A Cross-Lagged Analysis of Emotion Regulation, Peer Problems, and Emotional Problems in Children With and Without Early Language Difficulties: Evidence From the Millennium Cohort Study. ...
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Sound Discrimination and Explicit Mapping of Sounds to Meanings in Preschoolers with and Without Developmental Language Disorder
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In: Speech and Hearing Sciences Faculty Publications and Presentations (2020)
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Performance of the German version of the PARCA-R questionnaire as a developmental screening tool in two-year-old very preterm infants
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In: ISSN: 1932-6203 ; PLOS ONE, Vol. 15, No 9 (2020) P. e0236289 (2020)
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A Distinction Between Linguistic and Social Pragmatics Helps the Precise Characterization of Pragmatic Challenges in Children With Autism Spectrum Disorders and Developmental Language Disorder.
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Health comorbidities and cognitive abilities across the lifespan in Down syndrome.
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Startin, Carla M; D'Souza, Hana; Ball, George; Hamburg, Sarah; Hithersay, Rosalyn; Hughes, Kate MO; Massand, Esha; Karmiloff-Smith, Annette; Thomas, Michael SC; LonDownS Consortium; Strydom, Andre. - : Springer Science and Business Media LLC, 2020. : J Neurodev Disord, 2020
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Abstract:
BACKGROUND: Down syndrome (DS) is associated with variable intellectual disability and multiple health and psychiatric comorbidities. The impact of such comorbidities on cognitive outcomes is unknown. We aimed to describe patterns of physical health and psychiatric comorbidity prevalence, and receptive language ability, in DS across the lifespan, and determine relationships with cognitive outcomes. METHODS: Detailed medical histories were collected and cognitive abilities measured using standardised tests for 602 individuals with DS from England and Wales (age range 3 months to 73 years). Differences in prevalence rates between age groups and between males and females were determined using chi-squared or Fisher's exact tests. In adults, rates for psychiatric comorbidities were compared to expected population rates using standardised morbidity ratios (SMRs). Adapted ANCOVA functions were constructed to explore age and sex associations with receptive language ability across the lifespan, and regression analyses were performed to determine whether the presence of health comorbidities or physical phenotypes predicted cognitive abilities. RESULTS: Multiple comorbidities showed prevalence differences across the lifespan, though there were few sex differences. In adults, SMRs were increased in males and decreased in females with DS for schizophrenia, bipolar disorder, and anxiety. Further, SMRs were increased in both males and females with DS for dementia, autism, ADHD, and depression, with differences more pronounced in females for dementia and autism, and in males for depression. Across the lifespan, receptive language abilities increasingly deviated from age-typical levels, and males scored poorer than females. Only autism and epilepsy were associated with poorer cognitive ability in those aged 16-35 years, with no relationships for physical health comorbidities, including congenital heart defects. CONCLUSIONS: Our results indicate the prevalence of multiple comorbidities varies across the lifespan in DS, and in adults, rates for psychiatric comorbidities show different patterns for males and females relative to expected population rates. Further, most health comorbidities are not associated with poorer cognitive outcomes in DS, apart from autism and epilepsy. It is essential for clinicians to consider such differences to provide appropriate care and treatment for those with DS and to provide prognostic information relating to cognitive outcomes in those with comorbidities.
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Keyword:
80 and over; Adolescent; Adult; Aged; Child; Cognition; Comorbidity; Down Syndrome; Female; Humans; Infant; Language Development Disorders; LonDownS Consortium; Longevity; Male; Mental Disorders; Middle Aged; Preschool; Sex Characteristics; United Kingdom; Young Adult
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URL: https://doi.org/10.17863/CAM.58181 https://www.repository.cam.ac.uk/handle/1810/311092
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A Cross-Lagged Analysis of Emotion Regulation, Peer Problems, and Emotional Problems in Children With and Without Early Language Difficulties: Evidence From the Millennium Cohort Study.
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Exploring Language Use Within a Parent-Mediated Intervention for Children Exhibiting Social Communication Difficulties
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In: Discovery Park Undergraduate Research Internship Program (2020)
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Aspects of Joint Attention in Autism Spectrum Disorder: Links to Sensory Processing, Social Competence, Maternal Attention, and Contextual Factors
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