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Clinical progression of PPAOS (Utianski et al., 2018) ...
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Clinical progression of PPAOS (Utianski et al., 2018) ...
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23
Clinical Progression in Four Cases of Primary Progressive Apraxia of Speech
Utianski, Rene L.; Duffy, Joseph R.; Clark, Heather M.. - : American Speech-Language-Hearing Association, 2018
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24
Molecular Neuroimaging in an Agraphia Predominant Primary Progressive Aphasia
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25
Electroencephalography in Primary Progressive Aphasia and Apraxia of Speech
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26
Patterns of Neuropsychological Dysfunction and Cortical Volume Changes in Logopenic Aphasia
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27
[18F]AV-1451 tau-PET and primary progressive aphasia
Abstract: OBJECTIVES: To assess [(18)F]AV-1451 tau-PET uptake patterns across the primary progressive aphasia (PPA) variants (logopenic, semantic and agrammatic), examine regional uptake patterns of [(18)F]AV-1451 independent of clinical diagnosis, and compare the diagnostic utility of [(18)F]AV-1451, [(18)F]-fluorodeoxygluclose (FDG)-PET and MRI to differentiate the PPA variants. METHODS: We performed statistical parametric mapping of [(18)F]AV-1451 across 40 PPA patients (logopenic-PPA=14, semantic-PPA=13 and agrammatic-PPA=13) compared to 80 cognitively normal, PiB-negative controls, age and gender matched 2:1. Principal component analysis of regional [(18)F]AV-1451 tau-PET SUVR was performed to understand underlying patterns of [(18)F]AV-1451 uptake independent of clinical diagnosis. Penalized multinomial regression analyses were utilized to assess diagnostic utility. RESULTS: Logopenic-PPA showed striking uptake throughout neocortex, particularly temporoparietal, compared to controls, semantic-PPA and agrammatic-PPA. Semantic-PPA and agrammatic-PPA showed milder patterns of focal [(18)F]AV-1451 uptake. Semantic-PPA showed elevated uptake (left>right) in anteromedial temporal lobes, compared to controls and agrammatic-PPA. Agrammatic-PPA showed elevated uptake (left>right) throughout prefrontal white matter and in subcortical grey matter structures, compared to controls and semantic-PPA. The principal component analysis of regional [(18)F]AV-1451 indicated two primary dimensions, a severity dimension that distinguished logopenic-PPA from agrammatic-PPA and semantic-PPA, and a frontal-versus-temporal contrast that distinguishes agrammatic-PPA and semantic-PPA cases. Diagnostic utility of [(18)F]AV-1451was superior to MRI and at least equal to FDG-PET. INTERPRETATION: [(18)F]AV-1451binding characteristics differ across the PPA variants, and were excellent at distinguishing between the variants. [(18)F]AV-1451binding characteristics were as good or better than other brain imaging modalities utilized in clinical practice, suggesting that [(18)F]AV-1451 may have clinical diagnostic utility in PPA.
Keyword: Article
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896771/
http://www.ncbi.nlm.nih.gov/pubmed/29451323
https://doi.org/10.1002/ana.25183
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28
Tau Uptake in Agrammatic Primary Progressive Aphasia with and without Apraxia of Speech
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29
Quantitative Analysis of Agrammatism in Agrammatic Primary Progressive Aphasia and Dominant Apraxia of Speech
Tetzloff, Katerina A.; Utianski, Rene L.; Duffy, Joseph R.. - : American Speech-Language-Hearing Association, 2018
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30
Longitudinal structural and molecular neuroimaging in agrammatic primary progressive aphasia
Tetzloff, Katerina A; Duffy, Joseph R; Clark, Heather M. - : Oxford University Press, 2018
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31
Quantitative assessment of grammar in amyloid-negative logopenic aphasia
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32
Disrupted functional connectivity in primary progressive apraxia of speech
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33
Tau-PET imaging with [18F]AV-1451 in Primary Progressive Apraxia of Speech
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34
Prosodic and Phonetic Subtypes of Primary Progressive Apraxia of Speech
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35
Predicting clinical decline in progressive agrammatic aphasia and apraxia of speech
Whitwell, Jennifer L.; Weigand, Stephen D.; Duffy, Joseph R.. - : Lippincott Williams & Wilkins, 2017
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36
Varying degrees of temporoparietal hypometabolism on FDG-PET reveal amyloid-positive logopenic primary progressive aphasia is not a homogeneous clinical entity
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37
Temporal acoustic measures distinguish primary progressive apraxia of speech from primary progressive aphasia
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38
A Predictive model for diagnosing stroke-related apraxia of speech
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39
Tracking the Development of Agrammatic Aphasia: a Tensor-Based Morphometry Study
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40
Clinical and MRI models predicting amyloid deposition in progressive aphasia and apraxia of speech
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