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Hits 1 – 15 of 15

1
Parkinson’s Disease Cognitive Phenotypes Show Unique Clock Drawing Features When Measured with Digital Technology
In: J Parkinsons Dis (2021)
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2
Phenotyping Cognitive Impairment using Graphomotor and Latency Features in Digital Clock Drawing Test
In: Annu Int Conf IEEE Eng Med Biol Soc (2020)
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3
Visuospatial Performance in Patients with Statistically-Defined Mild Cognitive Impairment
In: J Clin Exp Neuropsychol (2020)
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4
Visuoconstructional Impairment in Subtypes of Mild Cognitive Impairment
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5
Comparative semantic profiles in semantic dementia and Alzheimer's disease
Libon, David J.; Rascovsky, Katya; Powers, John. - : Oxford University Press, 2013
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6
Sparse canonical correlation analysis relates network-level atrophy to multivariate cognitive measures in a neurodegenerative population
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7
Comparative semantic profiles in semantic dementia and Alzheimer’s disease
Libon, David J.; Rascovsky, Katya; Powers, John. - : Oxford University Press, 2013
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8
Sentence processing in Lewy body spectrum disorder: the role of working memory
In: Brain and cognition. - San Diego, Calif. [u.a.] : Elsevier Science 78 (2012) 2, 85-93
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9
Yes/No Versus Forced-Choice Recognition Memory in Mild Cognitive Impairment and Alzheimer’s Disease: Patterns of Impairment and Associations with Dementia Severity
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10
SENTENCE PROCESSING IN LEWY BODY SPECTRUM DISORDER: THE ROLE OF WORKING MEMORY
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11
The Philadelphia Brief Assessment of Cognition (PBAC): A Validated Screening Measure for Dementia
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12
The importance of multiple assessments of object knowledge in semantic dementia: The case of the familiar objects task
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13
Neuropsychological Decline in Frontotemporal Lobar Degeneration: A Longitudinal Analysis
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14
Longitudinal Patterns of Semantic and Episodic Memory in Frontotemporal Lobar Degeneration and Alzheimer’s Disease
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15
Neuropsychological patterns in magnetic resonance imaging-defined subgroups of patients with degenerative dementia
Abstract: We hypothesized that specific neuropsychological deficits were associated with specific patterns of atrophy. A magnetic resonance imaging volumetric study and a neuropsychological protocol were obtained for patients with several frontotemporal lobar dementia phenotypes including a social/dysexecutive (SOC/EXEC, n = 17), progressive nonfluent aphasia (n = 9), semantic dementia (n = 7), corticobasal syndrome (n = 9), and Alzheimer’s disease (n = 21). Blinded to testing results, patients were partitioned according to pattern of predominant cortical atrophy; our partitioning algorithm had been derived using seriation, a hierarchical classification technique. Neuropsychological test scores were regressed versus these atrophy patterns as fixed effects using the covariate total atrophy as marker for disease severity. The results showed the model accounted for substantial variance. Furthermore, the “large-scale networks” associated with each neuropsychological test conformed well to the known literature. For example, bilateral prefrontal cortical atrophy was exclusively associated with SOC/EXEC dysfunction. The neuropsychological principle of “double dissociation” was supported not just by such active associations but also by the “silence” of locations not previously implicated by the literature. We conclude that classifying patients with degenerative dementia by specific pattern of cortical atrophy has the potential to predict individual patterns of cognitive deficits.
Keyword: Article
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918516
http://www.ncbi.nlm.nih.gov/pubmed/19402932
https://doi.org/10.1017/S1355617709090742
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