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1
Difficulty processing temporary syntactic ambiguities in Lewy body spectrum disorder
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 120 (2012) 1, 52-60
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2
Sentence processing in Lewy body spectrum disorder: the role of working memory
In: Brain and cognition. - San Diego, Calif. [u.a.] : Elsevier Science 78 (2012) 2, 85-93
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SENTENCE PROCESSING IN LEWY BODY SPECTRUM DISORDER: THE ROLE OF WORKING MEMORY
Abstract: Prior work has related sentence processing to executive deficits in non-demented patients with Parkinson’s disease (PD). We extended this investigation to patients with dementia with Lewy bodies (DLB) and PD dementia (PDD) by examining grammatical and working memory components of sentence processing in the full range of patients with Lewy body spectrum disorder (LBSD). Thirty-three patients with LBSD were given a two-alternative, forced-choice sentence-picture matching task. Sentence type, working memory, and grammatical structure were systematically manipulated in the sentences. We found that patients with PDD and DLB were significantly impaired relative to non-demented PD patients and healthy controls. The deficit in PDD/DLB was most pronounced for sentences lengthened by the strategic placement of an additional prepositional phrase and for sentences with an additional proposition due to a center-embedded clause. However, there was no effect for subject-relative versus object-relative grammatical structure. An MRI voxel-based morphometry analysis in a subset of patients showed significant gray matter thinning in the frontal lobe bilaterally, and this extended to temporal, parietal and occipital regions. A regression analysis related sentence processing difficulty in LBSD to frontal neocortex, including inferiorprefrontal, premotor, and dorsolateral prefrontal regions, as well as right superior temporal cortex. These findings are consistent with the hypothesis that patients with PDD and DLB have difficulty processing sentences with increased working memory demands and that this deficit is related in part to their frontal disease.
Keyword: Article
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265703
http://www.ncbi.nlm.nih.gov/pubmed/22218297
https://doi.org/10.1016/j.bandc.2011.12.004
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4
Apathy in frontotemporal dementia: Behavioral and neuroimaging correlates
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5
DIFFICULTY PROCESSING TEMPORARY SYNTACTIC AMBIGUITIES IN LEWY BODY SPECTRUM DISORDER
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6
The Philadelphia Brief Assessment of Cognition (PBAC): A Validated Screening Measure for Dementia
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7
Social Cognition, Executive Functioning, and Neuroimaging Correlates of Empathic Deficits in Frontotemporal Dementia
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8
Speech errors in progressive non-fluent aphasia
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 113 (2010) 1, 13-20
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9
SPEECH ERRORS IN PROGRESSIVE NON-FLUENT APHASIA
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10
Non-fluent speech in frontotemporal lobar degeneration
In: Journal of neurolinguistics. - Orlando, Fla. : Elsevier 22 (2009) 4, 370-383
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11
Non-fluent speech in frontotemporal lobar degeneration
In: Journal of neurolinguistics. - Orlando, Fla. : Elsevier 22 (2009) 4, 370-383
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12
Neuropsychological Decline in Frontotemporal Lobar Degeneration: A Longitudinal Analysis
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13
Non-Fluent Speech in Frontotemporal Lobar Degeneration
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14
Longitudinal Patterns of Semantic and Episodic Memory in Frontotemporal Lobar Degeneration and Alzheimer’s Disease
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15
Neuropsychological patterns in magnetic resonance imaging-defined subgroups of patients with degenerative dementia
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16
Sentence comprehension and voxel-based morphometry in progressive nonfluent aphasia, semantic dementia, and nonaphasic frontotemporal dementia
In: Journal of neurolinguistics. - Orlando, Fla. : Elsevier 21 (2008) 5, 418-432
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17
Sentence comprehension and voxel-based morphometry in progressive nonfluent aphasia, semantic dementia, and nonaphasic frontotemporal dementia
In: Journal of neurolinguistics. - Orlando, Fla. : Elsevier 21 (2008) 5, 418-432
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18
Sentence comprehension and voxel-based morphometry in progressive nonfluent aphasia, semantic dementia, and nonaphasic frontotemporal dementia
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19
Syntactic and thematic components of sentence processing in progressive nonfluent aphasia and nonaphasic frontotemporal dementia
In: Journal of neurolinguistics. - Orlando, Fla. : Elsevier 20 (2007) 6, 482-494
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20
The decline of narrative discourse in Alzheimer’s disease
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 103 (2007) 1-2, 181
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