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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 9 of 9 1 New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures. Boxer, Adam L; Gold, Michael; Feldman, Howard... In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020) BASE Show details 2 New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures. Boxer, Adam L; Gold, Michael; Feldman, Howard; Boeve, Bradley F; Dickinson, Susan L-J; Fillit, Howard; Ho, Carole; Paul, Robert; Pearlman, Rodney; Sutherland, Margaret; Verma, Ajay; Arneric, Stephen P; Alexander, Brian M; Dickerson, Bradford C; Dorsey, Earl Ray; Grossman, Murray; Huey, Edward D; Irizarry, Michael C; Marks, William J; Masellis, Mario; McFarland, Frances; Niehoff, Debra; Onyike, Chiadi U; Paganoni, Sabrina; Panzara, Michael A; Rockwood, Kenneth; Rohrer, Jonathan D; Rosen, Howard; Schuck, Robert N; Soares, Holly D; Tatton, Nadine In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020) Abstract: IntroductionFrontotemporal lobar degeneration (FTLD) is the most common form of dementia for those under 60years of age. Increasing numbers of therapeutics targeting FTLD syndromes are being developed.MethodsIn March 2018, the Association for Frontotemporal Degeneration convened the Frontotemporal Degeneration Study Group meeting in Washington, DC, to discuss advances in the clinical science of FTLD.ResultsChallenges exist for conducting clinical trials in FTLD. Two of the greatest challenges are (1) the heterogeneity of FTLD syndromes leading to difficulties in efficiently measuring treatment effects and (2) the rarity of FTLD disorders leading to recruitment challenges.DiscussionNew personalized endpoints that are clinically meaningful to individuals and their families should be developed. Personalized approaches to analyzing MRI data, development of new fluid biomarkers and wearable technologies will help to improve the power to detect treatment effects in FTLD clinical trials and enable new, clinical trial designs, possibly leveraged from the experience of oncology trials. A computational visualization and analysis platform that can support novel analyses of combined clinical, genetic, imaging, biomarker data with other novel modalities will be critical to the success of these endeavors. Keyword: Acquired Cognitive Impairment; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer's Disease Related Dementias (ADRD); ARTFL; Atrophy; Biomarker; Biomarkers; Brain Disorders; C9orf72; Clinical Research; Clinical Sciences; Clinical trial; Clinical Trials and Supportive Activities; Clinical Trials as Topic; Congresses as Topic; Dementia; Frontotemporal dementia; Frontotemporal Dementia (FTD); Frontotemporal Lobar Degeneration; FTD; FTLD; Genetics; Geriatrics; GRN; Humans; LEFFTDS; Magnetic Resonance Imaging; MAPT; Neurodegenerative; Neurosciences; Primary progressive aphasia; Progressive supranuclear palsy; Rare Diseases URL: https://escholarship.org/uc/item/13t6f67b BASE Hide details 3 An Open-Labeled Trial of Bromocriptine in Nonfluent Aphasia: A Qualitative Analysis of Word Storage and Retrieval Gold, Michael; VanDam, Deborah; Silliman, Elaine R. In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 74 (2000) 2, 141-156 OLC Linguistik Show details 4 An open-label trial of bromocriptine in nonfluent aphasia : a qualitative analysis of word storage and retrieval Gold, Michael; VanDam, Deborah; Silliman, Elaine R. In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 74 (2000) 2, 141-156 BLLDB Show details 5 INTRODUCTION - Apraxia in Corticobasal Degeneration Jacobs, Daniel H.; Adair, John C.; Macauley, Beth... In: Brain and cognition. - San Diego, Calif. [u.a.] : Elsevier Science 40 (1999) 2, 336-354 OLC Linguistik Show details 6 Adynamic Aphasia: A Transcortical Motor Aphasia with Defective Semantic Strategy Formation Gold, Michael; Nadeau, Stephen E; Jacobs, Daniel H... In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 57 (1997) 3, 374-393 OLC Linguistik Show details 7 Adynamic aphasia : a transcortical motor aphasia with defective semantic strategy formation Gold, Michael; Nadeau, Stephen E.; Jacobs, Daniel H.... In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 57 (1997) 3, 374-393 BLLDB Show details 8 Adynamic Aphasia: A Transcortical Motor Aphasia with Defective Semantic Strategy Formation Department of Neurology, College of Medicine, University of Florida ( host institution ); Gold, Michael ( author ); Nadeau, Stephen E. ( author ). - : Elsevier Inc., 1997 BASE Show details 9 Adynamic Aphasia: A Transcortical Motor Aphasia with Defective Semantic Strategy Formation Department of Neurology, College of Medicine, University of Florida ( host institution ); Gold, Michael; Nadeau, Stephen E.. - : Elsevier Inc., 1997 BASE Show details

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