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1
Sensitive measures of cognition in Mild Cognitive Impairment
In: J Alzheimers Dis (2021)
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2
Longitudinal progression of grey matter atrophy in non-amnestic Alzheimer’s disease
In: Brain (2019)
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3
18F-Flortaucipir PET/MRI Correlations in Nonamnestic and Amnestic Variants of Alzheimer Disease
Nasrallah, Ilya M.; Chen, Yin Jie; Hsieh, Meng-Kang. - : Society of Nuclear Medicine, 2018
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4
Prevalence of Amyloid-β Pathology in Distinct Variants of Primary Progressive Aphasia
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5
Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia: Amyloid-β Pathology in PPA
In: Annals of Neurology. - 84, 5 (2018) , 729-740, ISSN: 0364-5134 (2018)
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6
Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia
Giannini, Lucia A.A.; Irwin, David J.; McMillan, Corey T.. - : Lippincott Williams & Wilkins, 2017
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7
Tau PET Imaging Predicts Cognition in Atypical Variants of Alzheimer’s Disease
Abstract: Accumulation of paired helical filament tau contributes to neurodegeneration in Alzheimer’s disease (AD). 18F-flortaucipir is a positron emission tomography (PET) radioligand sensitive to tau in AD, but its clinical utility will depend in part on its ability to predict cognitive symptoms in diverse dementia phenotypes associated with selective, regional uptake. We examined associations between 18F-flortaucipir and cognition in 14 mildly-impaired patients (12 with cerebrospinal fluid analytes consistent with AD pathology) who had amnestic (n=5) and non-amnestic AD syndromes, including posterior cortical atrophy (PCA, n=5) and logopenic-variant primary progressive aphasia (lvPPA, n=4). Amnestic AD patients had deficits in memory; lvPPA in language; and both amnestic AD and PCA patients in visuospatial function. Associations with cognition were tested using sparse regression and compared to associations in anatomical regions-of-interest (ROIs). 18F-flortaucipir uptake was expected to show regionally-specific correlations with each domain. In multivariate analyses, uptake was elevated in neocortical areas specifically associated with amnestic and non-amnestic syndromes. Uptake in left anterior superior temporal gyrus accounted for 67% of the variance in language performance. Uptake in right lingual gyrus predicted 85% of the variance in visuospatial performance. Memory was predicted by uptake in right fusiform gyrus and cuneus as well as a cluster comprising right anterior hippocampus and amygdala; this eigenvector explained 57% of the variance in patients’ scores. These results provide converging evidence for associations between 18F-flortaucipir uptake, tau pathology, and patients’ cognitive symptoms.
Keyword: Article
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764792/
https://doi.org/10.1002/hbm.23874
http://www.ncbi.nlm.nih.gov/pubmed/29105977
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8
Neocortical Origin and Progression of Grey Matter Atrophy In Non-Amnestic Alzheimer’s Disease
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9
Amyloid Imaging in Atypical Presentations of Alzheimer’s Disease
Wolk, David A.. - 2013
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10
Amyloid Imaging in Dementias With Atypical Presentation
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11
Improved Proper Name Recall in Aging after Electrical Stimulation of the Anterior Temporal Lobes
Ross, Lars A.; McCoy, David; Coslett, H. Branch. - : Frontiers Research Foundation, 2011
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12
Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional–executive network function in Alzheimer’s disease
Wolk, David A.; Dickerson, Bradford C.; Weiner, Michael. - : National Academy of Sciences, 2010
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13
Preserved metamemorial ability in patients with mild Alzheimer's disease : shifting response bias
In: Brain and cognition. - San Diego, Calif. [u.a.] : Elsevier Science 66 (2008) 1, 32-39
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14
Increased Responsiveness to Novelty is Associated with Successful Cognitive Aging
In: Journal of cognitive neuroscience. - Cambridge, Mass. : MIT Press Journals 18 (2006) 10, 1759-1773
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15
The role of sensory-motor information in object recognition: Evidence from category-specific visual agnosia
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 94 (2005) 2, 131-146
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16
The role of sensory-motor information in object recognition : evidence from category-specific visual agnosia
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 94 (2005) 2, 131-146
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