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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 16 of 16 1 Sensitive measures of cognition in Mild Cognitive Impairment Klooster, Nathaniel; Humphries, Stacey; Cardillo, Eileen... In: J Alzheimers Dis (2021) BASE Show details 2 Longitudinal progression of grey matter atrophy in non-amnestic Alzheimer’s disease Phillips, Jeffrey S; Da Re, Fulvio; Irwin, David J; McMillan, Corey T; Vaishnavi, Sanjeev N; Xie, Sharon X; Lee, Edward B; Cook, Philip A; Gee, James C; Shaw, Leslie M; Trojanowski, John Q; Wolk, David A; Grossman, Murray In: Brain (2019) Abstract: Recent models of Alzheimer’s disease progression propose that disease may be transmitted between brain areas either via local diffusion or long-distance transport via white matter fibre pathways. However, it is unclear whether such models are applicable in non-amnestic Alzheimer’s disease, which is associated with domain-specific cognitive deficits and relatively spared episodic memory. To date, the anatomical progression of disease in non-amnestic patients remains understudied. We used longitudinal imaging to differentiate earlier atrophy and later disease spread in three non-amnestic variants, including logopenic-variant primary progressive aphasia (n = 25), posterior cortical atrophy (n = 20), and frontal-variant Alzheimer’s disease (n = 12), as well as 17 amnestic Alzheimer’s disease patients. Patients were compared to 37 matched controls. All patients had autopsy (n = 7) or CSF (n = 67) evidence of Alzheimer’s disease pathology. We first assessed atrophy in suspected sites of disease origin, adjusting for age, sex, and severity of cognitive impairment; we then performed exploratory whole-brain analysis to investigate longitudinal disease spread both within and outside these regions. Additionally, we asked whether each phenotype exhibited more rapid change in its associated disease foci than other phenotypes. Finally, we investigated whether atrophy was related to structural brain connectivity. Each non-amnestic phenotype displayed unique patterns of initial atrophy and subsequent neocortical change that correlated with cognitive decline. Longitudinal atrophy included areas both proximal to and distant from sites of initial atrophy, suggesting heterogeneous mechanisms of disease spread. Moreover, regional rates of neocortical change differed by phenotype. Logopenic-variant patients exhibited greater initial atrophy and more rapid longitudinal change in left lateral temporal areas than other groups. Frontal-variant patients had pronounced atrophy in left insula and middle frontal gyrus, combined with more rapid atrophy of left insula than other non-amnestic patients. In the medial temporal lobes, non-amnestic patients had less atrophy at their initial scan than amnestic patients, but longitudinal rate of change did not differ between patient groups. Medial temporal sparing in non-amnestic Alzheimer’s disease may thus be due in part to later onset of medial temporal degeneration than in amnestic patients rather than different rates of atrophy over time. Finally, the magnitude of longitudinal atrophy was predicted by structural connectivity, measured in terms of node degree; this result provides indirect support for the role of long-distance fibre pathways in the spread of neurodegenerative disease. Keyword: Original Articles URL: https://doi.org/10.1093/brain/awz091 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585881/ http://www.ncbi.nlm.nih.gov/pubmed/31135048 BASE Hide details 3 18F-Flortaucipir PET/MRI Correlations in Nonamnestic and Amnestic Variants of Alzheimer Disease Nasrallah, Ilya M.; Chen, Yin Jie; Hsieh, Meng-Kang. - : Society of Nuclear Medicine, 2018 BASE Show details 4 Prevalence of Amyloid-β Pathology in Distinct Variants of Primary Progressive Aphasia Bergeron, David; Gorno-Tempini, Maria L.; Rabinovici, Gil D.. - 2018 BASE Show details 5 Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia: Amyloid-β Pathology in PPA Bergeron, David; Gorno-Tempini, Maria L.; Rabinovici, Gil D.... In: Annals of Neurology. - 84, 5 (2018) , 729-740, ISSN: 0364-5134 (2018) BASE Show details 6 Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia Giannini, Lucia A.A.; Irwin, David J.; McMillan, Corey T.. - : Lippincott Williams & Wilkins, 2017 BASE Show details 7 Tau PET Imaging Predicts Cognition in Atypical Variants of Alzheimer’s Disease Phillips, Jeffrey S.; Das, Sandhitsu R.; McMillan, Corey T.. - 2017 BASE Show details 8 Neocortical Origin and Progression of Grey Matter Atrophy In Non-Amnestic Alzheimer’s Disease Phillips, Jeffrey S.; Re, Fulvio Da; Dratch, Laynie. - 2017 BASE Show details 9 Amyloid Imaging in Atypical Presentations of Alzheimer’s Disease Wolk, David A.. - 2013 BASE Show details 10 Amyloid Imaging in Dementias With Atypical Presentation Wolk, David A.; Price, Julie C.; Madeira, Charles. - 2012 BASE Show details 11 Improved Proper Name Recall in Aging after Electrical Stimulation of the Anterior Temporal Lobes Ross, Lars A.; McCoy, David; Coslett, H. Branch. - : Frontiers Research Foundation, 2011 BASE Show details 12 Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional–executive network function in Alzheimer’s disease Wolk, David A.; Dickerson, Bradford C.; Weiner, Michael. - : National Academy of Sciences, 2010 BASE Show details 13 Preserved metamemorial ability in patients with mild Alzheimer's disease : shifting response bias Budson, Andrew E.; Waring, Jill D.; Chong, Hyemi... In: Brain and cognition. - San Diego, Calif. [u.a.] : Elsevier Science 66 (2008) 1, 32-39 BLLDB OLC Linguistik Show details 14 Increased Responsiveness to Novelty is Associated with Successful Cognitive Aging Daffner, Kirk R.; Ryan, Katherine K.; Williams, Danielle M.... In: Journal of cognitive neuroscience. - Cambridge, Mass. : MIT Press Journals 18 (2006) 10, 1759-1773 OLC Linguistik Show details 15 The role of sensory-motor information in object recognition: Evidence from category-specific visual agnosia Wolk, David A.; Coslett, H.Branch; Glosser, Guila In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 94 (2005) 2, 131-146 OLC Linguistik Show details 16 The role of sensory-motor information in object recognition : evidence from category-specific visual agnosia Wolk, David A.; Coslett, H. Branch; Glosser, Guila In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 94 (2005) 2, 131-146 BLLDB Show details

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