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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 3 4 5...236 Hits 1 – 20 of 4.707 1 Cortical microstructure in primary progressive aphasia: a multicenter study. Illán-Gala, Ignacio; Montal, Victor; Borrego-Écija, Sergi; Mandelli, Maria Luisa; Falgàs, Neus; Welch, Ariane E; Pegueroles, Jordi; Santos-Santos, Miguel; Bejanin, Alexandre; Alcolea, Daniel; Dols-Icardo, Oriol; Belbin, Olivia; Sánchez-Saudinós, Mª Belén; Bargalló, Nuria; González-Ortiz, Sofía; Lladó, Albert; Blesa, Rafael; Dickerson, Bradford C; Rosen, Howard J; Miller, Bruce L; Lleó, Alberto; Gorno-Tempini, Maria Luisa; Sánchez-Valle, Raquel; Fortea, Juan In: Alzheimer's research & therapy, vol 14, iss 1 (2022) Abstract: BackgroundCortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been proposed as a sensitive biomarker that might antedate macroscopic cortical changes. We aimed to test the hypothesis that cortical mean diffusivity is more sensitive than cortical thickness to detect cortical changes in primary progressive aphasia (PPA).MethodsIn this multicenter, case-control study, we recruited 120 patients with PPA (52 non-fluent, 31 semantic, and 32 logopenic variants; and 5 GRN-related PPA) as well as 89 controls from three centers. The 3-Tesla MRI protocol included structural and diffusion-weighted sequences. Disease severity was assessed with the Clinical Dementia Rating scale. Cortical thickness and cortical mean diffusivity were computed using a surface-based approach.ResultsThe comparison between each PPA variant and controls revealed cortical mean diffusivity increases and cortical thinning in overlapping regions, reflecting the canonical loci of neurodegeneration of each variant. Importantly, cortical mean diffusivity increases also expanded to other PPA-related areas and correlated with disease severity in all PPA groups. Cortical mean diffusivity was also increased in patients with very mild PPA when only minimal cortical thinning was observed and showed a good correlation with measures of disease severity.ConclusionsCortical mean diffusivity shows promise as a sensitive biomarker for the study of the neurodegeneration-related microstructural changes in PPA. Keyword: 2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aging; Alzheimer's disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer’s disease; Aphasia; Biomedical Imaging; Brain Disorders; Case-Control Studies; Clinical Research; Dementia; Diffusion; Diffusion Magnetic Resonance Imaging; Frontotemporal Dementia (FTD); Frontotemporal lobar degeneration; Humans; Magnetic resonance; Magnetic Resonance Imaging; Medical and Health Sciences; Neurodegenerative; Neurological; Neurosciences; Primary Progressive; Primary progressive aphasia; Rare Diseases URL: https://escholarship.org/uc/item/4td346vg BASE Hide details 2 Moderators and predictors in a parent hearing aid management eHealth program ... San Miguel, Guadalupe G.; Muñoz, Karen; Barrett, Tyson S.. - : Taylor & Francis, 2022 BASE Show details 3 Moderators and predictors in a parent hearing aid management eHealth program ... San Miguel, Guadalupe G.; Muñoz, Karen; Barrett, Tyson S.. - : Taylor & Francis, 2022 BASE Show details 4 Cambridge Psycholinguistic Inventory of Christian Beliefs: A registered report of construct validity, internal consistency and test-retest reliability. ... Clackson, Kaili; Pohran, Nadya; Galli, Riccardo M. - : Apollo - University of Cambridge Repository, 2022 BASE Show details 5 Localization ... Jiménez Crespo, Miguel Ángel. - : Zenodo, 2022 BASE Show details 6 Localization ... Jiménez Crespo, Miguel Ángel. - : Zenodo, 2022 BASE Show details 7 World Literature & Linguistics, vol. 1, n.° 1, 2022. Número completo ... Barreto, Israel Barrutia; Girón, Jonathan Caicedo; Camargo, Rafael Ernesto. - : Zenodo, 2022 BASE Show details 8 World Literature & Linguistics, vol. 1, n.° 1, 2022. Número completo ... Barreto, Israel Barrutia; Girón, Jonathan Caicedo; Camargo, Rafael Ernesto. - : Zenodo, 2022 BASE Show details 9 Towards a Perceptual Model for Estimating the Quality of Visual Speech ... Aldeneh, Zakaria; Fedzechkina, Masha; Seto, Skyler. - : arXiv, 2022 BASE Show details 10 «Entrevista al Dr. Darío Villanueva, académico de número de la Real Academia Española. "Sin la creación, no existe literatura, pero solo con la creación de textos tampoco hay literatura"» ... Delgado Del Aguila, Jesús Miguel. - : figshare, 2022 BASE Show details 11 «Entrevista al Dr. Darío Villanueva, académico de número de la Real Academia Española. "Sin la creación, no existe literatura, pero solo con la creación de textos tampoco hay literatura"» ... Delgado Del Aguila, Jesús Miguel. - : figshare, 2022 BASE Show details 12 «Entrevista al doctor Darío Villanueva. “Sin la creación, no existe literatura, pero solo con la creación de textos tampoco hay literatura”» ... Delgado Del Aguila, Jesús Miguel. - : figshare, 2022 BASE Show details 13 Imagination-Augmented Natural Language Understanding ... Lu, Yujie; Zhu, Wanrong; Wang, Xin Eric. - : arXiv, 2022 BASE Show details 14 Entrevista a José Manuel Sánchez Ron, vicedirector de la Real Academia Española. Búsqueda de métodos de investigación de la Literatura en conjunción con la Física ... Delgado Del Aguila, Jesús Miguel. - : figshare, 2022 BASE Show details 15 Entrevista a José Manuel Sánchez Ron, vicedirector de la Real Academia Española. Búsqueda de métodos de investigación de la Literatura en conjunción con la Física ... Delgado Del Aguila, Jesús Miguel. - : figshare, 2022 BASE Show details 16 Entrevista a José Manuel Sánchez Ron, vicedirector de la Real Academia Española. Búsqueda de métodos de investigación de la Literatura en conjunción con la Física ... Delgado Del Aguila, Jesús Miguel. - : figshare, 2022 BASE Show details 17 Verbal Fluency & BNT ... Miguel Fernández. - : Mendeley, 2022 BASE Show details 18 Verbal Fluency & BNT ... Miguel Fernández. - : Mendeley, 2022 BASE Show details 19 Linguagem Específica de Domínio para a Integração de Sistemas Ciber Físicos ; Domain Specific Languages for Cyber-Physical Systems Component Integration Oliveira , Paulo Renato Mendes. - 2022 BASE Show details 20 Que futuro para a igualdade? Pensar a sociedade e o pós-pandemia Carmo, Renato Miguel do; Tavares, Inês; Cândido, Ana Filipa. - : Observatório das Desigualdades, 2022 BASE Show details Page: 1 2 3 4 5...236

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