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1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans
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Functional organisation for verb generation in children with developmental language disorder
In: Neuroimage (2021)
Abstract: Developmental language disorder (DLD) is characterised by difficulties in learning one's native language for no apparent reason. These language difficulties occur in 7% of children and are known to limit future academic and social achievement. Our understanding of the brain abnormalities associated with DLD is limited. Here, we used a simple four-minute verb generation task (children saw a picture of an object and were instructed to say an action that goes with that object) to test children between the ages of 10–15 years (DLD N = 50, typically developing N = 67). We also tested 26 children with poor language ability who did not meet our criteria for DLD. Contrary to our registered predictions, we found that children with DLD did not have (i) reduced activity in language relevant regions such as the left inferior frontal cortex; (ii) dysfunctional striatal activity during overt production; or (iii) a reduction in left-lateralised activity in frontal cortex. Indeed, performance of this simple language task evoked activity in children with DLD in the same regions and to a similar level as in typically developing children. Consistent with previous reports, we found sub-threshold group differences in the left inferior frontal gyrus and caudate nuclei, but only when analysis was limited to a subsample of the DLD group (N = 14) who had the poorest performance on the task. Additionally, we used a two-factor model to capture variation in all children studied (N = 143) on a range of neuropsychological tests and found that these language and verbal memory factors correlated with activity in different brain regions. Our findings indicate a lack of support for some neurological models of atypical language learning, such as the procedural deficit hypothesis or the atypical lateralization hypothesis, at least when using simple language tasks that children can perform. These results also emphasise the importance of controlling for and monitoring task performance.
Keyword: Article
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836232/
http://www.ncbi.nlm.nih.gov/pubmed/33285329
https://doi.org/10.1016/j.neuroimage.2020.117599
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3
Investigating the effects of handedness on the consistency of lateralization for speech production and semantic processing tasks using functional transcranial Doppler sonography
Bruckert, L.; Thompson, Paul A.; Watkins, K. E.. - : Taylor & Francis, 2021
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4
Profile of language abilities in a sample of adults with developmental disorders
Bradshaw, Abigail R.; Woodhead, Zoe V. J.; Thompson, Paul A.. - : John Wiley & Sons Ltd., 2021
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5
Functional organisation for verb generation in children with developmental language disorder
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6
PP30 The ambulance service and the child and young persons advance care plan: listening to families and professionals
Shaw, Karen; Spry, Jenna; Cottrell, Serena. - : BMJ Publishing Group Ltd, 2020
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7
L2 writers referencing corpora to address accuracy: a qualitative analysis of learners' lexicogrammatical error corrections
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8
The division of deontic labour in the discourse of HIV/AIDS post-1996. A critical discourse analysis of necessity and obligation in the British press and interviews with gay men with HIV
Ghio, Ivan. - 2020
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9
Linguistic variation across Twitter and Twitter trolling
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10
Linguistic and cultural oppositions in discourse about Thailand
Sukaew, Thitima. - 2020
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11
Profile of language abilities in a sample of adults with developmental disorders
In: Dyslexia (2020)
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12
Investigation into inconsistent lateralisation of language functions as a potential risk factor for language impairment
Bradshaw, Abigail R.; Woodhead, Zoe V. J.; Thompson, Paul A.. - : Wiley-Blackwell Publishing Ltd., 2020
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13
Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets
In: ISSN: 2041-1723 ; EISSN: 2041-1723 ; Nature Communications ; https://hal.archives-ouvertes.fr/hal-02365089 ; Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-13005-8⟩ (2019)
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14
Measurement of $W^{\pm}$-boson and $Z$-boson production cross-sections in $pp$ collisions at $\sqrt{s}=2.76$ TeV with the ATLAS detector
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15
Sulcal morphology in Alzheimer's disease: an effective marker of diagnosis and cognition
In: ISSN: 0197-4580 ; Neurobiology of Aging ; https://www.hal.inserm.fr/inserm-02266990 ; Neurobiology of Aging, Elsevier, 2019, Epub ahead of print. ⟨10.1016/j.neurobiolaging.2019.07.015⟩ (2019)
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16
The language of oral presentations given by PhD researchers in an EAP class: level of performance and disciplinary differences
Nausa, Ricardo. - 2019
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17
21st century language policy in Jamaica and Trinidad and Tobago
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18
Designing L2 literature circle discussion: tools for teachers and researchers
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19
Lexical phrases in research article and PhD thesis abstracts in applied linguistics and psychology
Ileri, Nurcan. - 2019
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20
Evaluative rhetorical strategies in the broadsheet review genre: the case of four British broadsheets
Ierace, Gaia. - 2019
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