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Common genetic variants in FOXP2 are not associated with individual differences in language development
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| 2 |
Measurement of the muon reconstruction performance of the ATLAS detector using 2011 and 2012 LHC proton-proton collision data.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2014)
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Observation of $Z$ production in proton-lead collisions at LHCb
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In: Symplectic Elements at Oxford ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; ArXiv (http://arxiv.org/) (2014)
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Observation of $Z$ production in proton-lead collisions at LHCb
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In: LHCb Collaboration; Bernet, R; Müller, K; Steinkamp, O; Straumann, U; Serra, N; Vollhardt, A; et al (2014). Observation of $Z$ production in proton-lead collisions at LHCb. Journal of High Energy Physics, 2014(30):online. (2014)
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| 5 |
Auditory stroop and absolute pitch: an fMRI study.
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In: Hum Brain Mapp , 34 (7) 1579 - 1590. (2013) (2013)
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Generative FDG-PET and MRI model of aging and disease progression in Alzheimer's disease.
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In: PLOS Computational Biology, vol. 9, no. 4, pp. e1002987 (2013)
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Abstract:
The failure of current strategies to provide an explanation for controversial findings on the pattern of pathophysiological changes in Alzheimer's Disease (AD) motivates the necessity to develop new integrative approaches based on multi-modal neuroimaging data that captures various aspects of disease pathology. Previous studies using [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) and structural magnetic resonance imaging (sMRI) report controversial results about time-line, spatial extent and magnitude of glucose hypometabolism and atrophy in AD that depend on clinical and demographic characteristics of the studied populations. Here, we provide and validate at a group level a generative anatomical model of glucose hypo-metabolism and atrophy progression in AD based on FDG-PET and sMRI data of 80 patients and 79 healthy controls to describe expected age and symptom severity related changes in AD relative to a baseline provided by healthy aging. We demonstrate a high level of anatomical accuracy for both modalities yielding strongly age- and symptom-severity- dependant glucose hypometabolism in temporal, parietal and precuneal regions and a more extensive network of atrophy in hippocampal, temporal, parietal, occipital and posterior caudate regions. The model suggests greater and more consistent changes in FDG-PET compared to sMRI at earlier and the inversion of this pattern at more advanced AD stages. Our model describes, integrates and predicts characteristic patterns of AD related pathology, uncontaminated by normal age effects, derived from multi-modal data. It further provides an integrative explanation for findings suggesting a dissociation between early- and late-onset AD. The generative model offers a basis for further development of individualized biomarkers allowing accurate early diagnosis and treatment evaluation.
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URL: https://doi.org/10.1371/journal.pcbi.1002987
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_F1DBEC7E3B779
https://serval.unil.ch/notice/serval:BIB_F1DBEC7E3B77
https://serval.unil.ch/resource/serval:BIB_F1DBEC7E3B77.P001/REF.pdf
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| 7 |
Overweight and obesity are associated with neuronal injury in the human cerebellum and hippocampus in young adults: a combined MRI, serum marker and gene expression study
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| 8 |
Effect of antenatal corticosteroids on fetal growth and gestational age at birth.
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In: Obstetrics and Gynecology, vol. 119, no. 5, pp. 917-923 (2012)
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| 9 |
Neuroarchitecture of Verbal and Tonal Working Memory in Nonmusicians and Musicians
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In: HUM BRAIN MAPP , 32 (5) 771 - 783. (2011) (2011)
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| 10 |
Maternal side-effects after multiple courses of antenatal corticosteroids (MACS): the three-month follow-up of women in the randomized controlled trial of MACS for preterm birth study.
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In: Journal of Obstetrics and Gynaecology Canada, vol. 33, no. 9, pp. 909-921 (2011)
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| 11 |
Functional architecture of verbal and tonal working memory: an FMRI study.
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In: Hum Brain Mapp , 30 (3) 859 - 873. (2009) (2009)
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Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial.
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In: Lancet, vol. 372, no. 9656, pp. 2143-2151 (2008)
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