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Investigating the effects of noise exposure on self-report, behavioral and electrophysiological indices of hearing damage in musicians with normal audiometric thresholds
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Sub-Clinical Auditory Neural Deficits in Patients with Type 1 Diabetes Mellitus
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Effects of Age and Noise Exposure on Proxy Measures of Cochlear Synaptopathy
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Subclinical Auditory Neural Deficits in Patients With Type 1 Diabetes Mellitus
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In: Ear Hear (2019)
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Impaired speech perception in noise with a normal audiogram:No evidence for cochlear synaptopathy and no relation to lifetime noise exposure
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Impaired speech perception in noise with a normal audiogram: No evidence for cochlear synaptopathy and no relation to lifetime noise exposure
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Abstract:
In rodents, noise exposure can destroy synapses between inner hair cells and auditory nerve fibers (“cochlear synaptopathy”) without causing hair cell loss. Noise-induced cochlear synaptopathy usually leaves cochlear thresholds unaltered, but is associated with long-term reductions in auditory brainstem response (ABR) amplitudes at medium-to-high sound levels. This pathophysiology has been suggested to degrade speech perception in noise (SPiN), perhaps explaining why SPiN ability varies so widely among audiometrically normal humans. The present study is the first to test for evidence of cochlear synaptopathy in humans with significant SPiN impairment. Individuals were recruited on the basis of self-reported SPiN difficulties and normal pure tone audiometric thresholds. Performance on a listening task identified a subset with “verified” SPiN impairment. This group was matched with controls on the basis of age, sex, and audiometric thresholds up to 14 kHz. ABRs and envelope-following responses (EFRs) were recorded at high stimulus levels, yielding both raw amplitude measures and within-subject difference measures. Past exposure to high sound levels was assessed by detailed structured interview. Impaired SPiN was not associated with greater lifetime noise exposure, nor with any electrophysiological measure. It is conceivable that retrospective self-report cannot reliably capture noise exposure, and that ABRs and EFRs offer limited sensitivity to synaptopathy in humans. Nevertheless, the results do not support the notion that noise-induced synaptopathy is a significant etiology of SPiN impairment with normal audiometric thresholds. It may be that synaptopathy alone does not have significant perceptual consequences, or is not widespread in humans with normal audiograms.
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URL: http://www.ncbi.nlm.nih.gov/pubmed/29680183
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993872/
https://doi.org/10.1016/j.heares.2018.03.008
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Magnified neural envelope coding predicts deficits in speech perception in noise
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Amplitude Modulation detection ability can be differentially affected using state-dependent Transcranial Magnetic Stimulation ...
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Magnified Neural Envelope Coding Predicts Deficits in Speech Perception in Noise
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Neural mechanisms underlying song and speech perception can be differentiated using an illusory percept
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Extracting Amplitude Modulations from Speech in the Time Domain
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In: ISSN: 0167-6393 ; EISSN: 1872-7182 ; Speech Communication ; https://hal.archives-ouvertes.fr/hal-00746108 ; Speech Communication, Elsevier : North-Holland, 2011, 53 (6), pp.903. ⟨10.1016/j.specom.2011.03.002⟩ (2011)
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