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UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings
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Functional maintenance in the multiple demand network characterizes superior fluid intelligence in aging
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Communication disorders in young children with cerebral palsy
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The influence of contextual constraint on verbal selection mechanisms and its neural correlates in Parkinson’s disease
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Posttraumatic growth following aphasia: a prospective cohort study of the first year post-stroke
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William Rutherford Sanders (1828-1881) and his neurologically fertile years (1865-1868)
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Establishing consensus on a definition of aphasia: an e-Delphi study of international aphasia researchers
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A narrative review of communication accessibility for people with aphasia and implications for multi-disciplinary goal setting after stroke
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Potential unintended effects of standardized pain questionnaires: A qualitative study
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Activation-based association profiles differentiate network roles across cognitive loads
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The functional communication classification system: extended reliability and concurrent validity for children with cerebral palsy aged 5 to 18 years
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Neuroplasticity and aphasia treatments: New approaches for an old problem
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Functional correlates of strategy formation and verbal suppression in Parkinson's disease
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Abstract:
Individuals with Parkinson's disease (PD) have shown impaired performance on the verbal suppression component of the Haylings Sentence Completion Test (HSCT). The present study aimed to determine whether this performance related to (i) the inability to suppress a pre-potent response or (ii) difficulty in the generation of a strategy to facilitate task execution. The study adopted a novel variation of the HSCT that isolated each process and employed fMRI to examine the associated neural correlates in a comparison of individuals with PD and matched healthy controls. No significant behavioral differences were detected between these two groups. However, fMRI results revealed atypical underlying neural activity in the PD group. Controls exhibited increased activation in the left dorsolateral prefrontal cortex and striatum when generating a response independently, relative to generation when a supporting strategy was provided. The PD group demonstrated the opposite pattern of activation, in addition to greater recruitment of right hemisphere regions. This pattern of activation was postulated to be evidence of compensatory mechanisms, acting to bolster the output of frontostriatal circuits compromised by disease pathology.
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Keyword:
2728 Clinical Neurology; 2741 Radiology Nuclear Medicine and imaging; 2805 Cognitive Neuroscience; 2808 Neurology; fMRI; Inhibition; Lexical-semantics; Parkinson's disease; Prefrontal cortex
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URL: https://espace.library.uq.edu.au/view/UQ:c3fa346
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Selection for sentence generation in the context of severe anomia: A case series of left temporal patients
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Semantic processing in children with cochlear implants: evidence from event-related potentials
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RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia
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Current practice and barriers and facilitators to outcome measurement in aphasia rehabilitation: a cross-sectional study using the theoretical domains framework
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Language as a predictor of motor recovery: the case for a more global approach to stroke rehabilitation
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Language and language disorders: neuroscience to clinical practice
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A how-to guide to aphasia services: celebrating Professor Linda Worrall’s contribution to the field
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