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The genetic architecture of oral language, reading fluency, and reading comprehension : A twin study from 7 to 16 years
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The Genetic Architecture of Oral Language, Reading Fluency, and Reading Comprehension: A Twin Study From 7 to 16 Years
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Fine mapping genetic associations between the HLA region and extremely high intelligence
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Socioeconomic status and the growth of intelligence from infancy through adolescence
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Why does parental language input style predict child language development? A twin study of gene–environment correlation
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Details of Genomewide Association Results, Protocol, Statistical Analysis, and Additional References (Harlaar et al., 2014) ...
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Details of Genomewide Association Results, Protocol, Statistical Analysis, and Additional References (Harlaar et al., 2014) ...
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Language impairment from 4 to 12 years : : prediction and etiology
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Common variation near ROBO2 is associated with expressive vocabulary in infancy
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St Pourcain, Beate; Cents, Rolieke A. M.; Whitehouse, Andrew J. O.; Haworth, Claire M. A.; Davis, Oliver S. P.; O’Reilly, Paul F.; Roulstone, Susan; Wren, Yvonne; Ang, Qi W.; Velders, Fleur P.; Evans, David M.; Kemp, John P.; Warrington, Nicole M.; Miller, Laura; Timpson, Nicholas J.; Ring, Susan M.; Verhulst, Frank C.; Hofman, Albert; Rivadeneira, Fernando; Meaburn, Emma L.; Price, Thomas S.; Dale, Philip S.; Pillas, Demetris; Yliherva, Anneli; Rodriguez, Alina; Golding, Jean; Jaddoe, Vincent W. V.; Jarvelin, Marjo-Riitta; Plomin, Robert; Pennell, Craig E.; Tiemeier, Henning; Davey Smith, George. - : Nature Publishing Group, 2014
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Abstract:
Twin studies suggest that expressive vocabulary at ~24 months is modestly heritable. However, the genes influencing this early linguistic phenotype are unknown. Here we conduct a genome-wide screen and follow-up study of expressive vocabulary in toddlers of European descent from up to four studies of the EArly Genetics and Lifecourse Epidemiology consortium, analysing an early (15–18 months, ‘one-word stage’, NTotal=8,889) and a later (24–30 months, ‘two-word stage’, NTotal=10,819) phase of language acquisition. For the early phase, one single-nucleotide polymorphism (rs7642482) at 3p12.3 near ROBO2, encoding a conserved axon-binding receptor, reaches the genome-wide significance level (P=1.3 × 10−8) in the combined sample. This association links language-related common genetic variation in the general population to a potential autism susceptibility locus and a linkage region for dyslexia, speech-sound disorder and reading. The contribution of common genetic influences is, although modest, supported by genome-wide complex trait analysis (meta-GCTA h215–18-months=0.13, meta-GCTA h224–30-months=0.14) and in concordance with additional twin analysis (5,733 pairs of European descent, h224-months=0.20).
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Keyword:
C420 Human Genetics; C841 Health Psychology
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URL: https://doi.org/10.1038/ncomms5831 https://eprints.lincoln.ac.uk/id/eprint/22920/ https://eprints.lincoln.ac.uk/id/eprint/22920/1/22920%20ncomms5831.pdf
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Common variation near ROBO2 is associated with expressive vocabulary in infancy
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Genome-Wide Association Study of Receptive Language Ability of 12-Year-Olds
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The high heritability of educational achievement reflects many genetically influenced traits, not just intelligence
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Genome-wide association study of receptive language ability of 12-year-olds
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Common variation near ROBO2 is associated with expressive vocabulary in infancy
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Genome-wide association study of receptive language ability of 12-year-olds
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Common variation near ROBO2 is associated with expressive vocabulary in infancy
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Childhood intelligence is heritable, highly polygenic and associated with FNBP1L
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