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The genetic architecture of oral language, reading fluency, and reading comprehension : A twin study from 7 to 16 years
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The Genetic Architecture of Oral Language, Reading Fluency, and Reading Comprehension: A Twin Study From 7 to 16 Years
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Fine mapping genetic associations between the HLA region and extremely high intelligence
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Socioeconomic status and the growth of intelligence from infancy through adolescence
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Why does parental language input style predict child language development? A twin study of gene–environment correlation
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Details of Genomewide Association Results, Protocol, Statistical Analysis, and Additional References (Harlaar et al., 2014) ...
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Details of Genomewide Association Results, Protocol, Statistical Analysis, and Additional References (Harlaar et al., 2014) ...
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Language impairment from 4 to 12 years : : prediction and etiology
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Common variation near ROBO2 is associated with expressive vocabulary in infancy
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Common variation near ROBO2 is associated with expressive vocabulary in infancy
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Genome-Wide Association Study of Receptive Language Ability of 12-Year-Olds
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The high heritability of educational achievement reflects many genetically influenced traits, not just intelligence
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Genome-wide association study of receptive language ability of 12-year-olds
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Common variation near ROBO2 is associated with expressive vocabulary in infancy
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Genome-wide association study of receptive language ability of 12-year-olds
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Harlaar, Nicole; Meaburn, Emma L.; Hayiou-Thomas, Marianna E.; Davis, Oliver S. P.; Docherty, Sophia; Hanscombe, Ken B.; Haworth, Claire M. A.; Price, Tom S.; Trzaskowski, Maciej; Dale, Philip S.; Plomin, Robert. - : American Speech - Language - Hearing Association, 2014
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Abstract:
Purpose: Researchers have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. In the current study, the authors attempted to identify some of the genes responsible for the heritability of receptive language ability using a genome-wide association approach. Method: The authors administered 4 Internet-based measures of receptive language (vocabulary, semantics, syntax, and pragmatics) to a sample of 2,329 twelve-year-olds for whom DNA and genome-wide genotyping were available. Nearly 700,000 single-nucleotide polymorphisms (SNPs) and 1 million imputed SNPs were included in a genome-wide association analysis of receptive language composite scores. Results: No SNP associations met the demanding criterion of genome-wide significance that corrects for multiple testing across the genome ( p < 5 × 10 −8). The strongest SNP association did not replicate in an additional sample of 2,639 twelve-year-olds. Conclusions: These results indicate that individual differences in receptive language ability in the general population do not reflect common genetic variants that account for more than 3% of the phenotypic variance. The search for genetic variants associated with language skill will require larger samples and additional methods to identify and functionally characterize the full spectrum of risk variants.
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Keyword:
P Philology. Linguistics; RJ Pediatrics
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URL: http://wrap.warwick.ac.uk/65857/ https://doi.org/10.1044/1092-4388 http://wrap.warwick.ac.uk/65857/1/WRAP_JSLHR_57_1_96.pdf
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Common variation near ROBO2 is associated with expressive vocabulary in infancy
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Childhood intelligence is heritable, highly polygenic and associated with FNBP1L
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