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The puzzling nuanced status of who free relative clauses in English: a follow-up to Patterson and Caponigro (2015)
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In: ENGLISH LANGUAGE & LINGUISTICS, vol 26, iss 1 (2022)
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Preview benefits and preview costs during reading: Exploring the interplay between display change awareness and parafoveal visual degradation (VISDEG2 project)) ...
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Spectral Degradation Influences Phonological Memory in Typically Hearing Adults
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In: Communication Disorders Faculty Publications (2021)
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SOCIO-CULTURAL TRANSFORMATION IN POST-SOVIET UKRAINE ; СОЦИОКУЛЬТУРНАЯ ТРАНСФОРМАЦИЯ В ПОСТСОВЕТСКОЙ УКРАИНЕ ; СОЦІОКУЛЬТУРНА ТРАНСФОРМАЦІЯ В ПОСТРАДЯНСЬКІЙ УКРАЇНІ
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In: Skhid; No. 1(2) (2021): PHILOSOPHICAL SCIENCES; 43-51 ; Схид; № 1(2) (2021): ФИЛОСОФСКИЕ НАУКИ; 43-51 ; Схід; № 1(2) (2021): ФІЛОСОФСЬКІ НАУКИ; 43-51 ; 2411-3093 ; 1728-9343 ; 10.21847/1728-9343.2021.1(2) (2021)
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Benchmark for the evaluation of named entity recognition over ancient documents ...
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Benchmark for the evaluation of named entity recognition over ancient documents ...
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Mapping of soil degradation and vulnerability in the Noun Syed watershed by water erosion: what impacts of climate change approach by remote sensing and GIS ...
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AOURAGH, Mbark. - : Environmental and Water Sciences, public Health and Territorial Intelligence Journal, 2020
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A Review on Alkali-Silica Reaction Evolution in Recycled Aggregate Concrete
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In: Materials ; Volume 13 ; Issue 11 (2020)
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Soil organic carbon stocks and trends (1984-2019) predicted at 30m spatial resolution for topsoil in natural areas of South Africa ...
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Soil organic carbon stocks and trends (1984-2019) predicted at 30m spatial resolution for topsoil in natural areas of South Africa ...
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High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation
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In: J Biol Chem (2019)
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Polyadenylate-binding protein–interacting proteins PAIP1 and PAIP2 affect translation termination
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In: J Biol Chem (2019)
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Abstract:
Polyadenylate-binding protein (PABP) stimulates translation termination via interaction of its C-terminal domain with eukaryotic polypeptide chain release factor, eRF3. Additionally, two other proteins, poly(A)-binding protein-interacting proteins 1 and 2 (PAIP1 and PAIP2), bind the same domain of PABP and regulate its translation-related activity. To study the biochemistry of eRF3 and PAIP1/2 competition for PABP binding, we quantified the effects of PAIPs on translation termination in the presence or absence of PABP. Our results demonstrated that both PAIP1 and PAIP2 prevented translation termination at the premature termination codon, by controlling PABP activity. Moreover, PAIP1 and PAIP2 inhibited the activity of free PABP on translation termination in vitro. However, after binding the poly(A) tail, PABP became insensitive to suppression by PAIPs and efficiently activated translation termination in the presence of eRF3a. Additionally, we revealed that PAIP1 binds eRF3 in solution, which stabilizes the post-termination complex. These results indicated that PAIP1 and PAIP2 participate in translation termination and are important regulators of readthrough at the premature termination codon.
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Keyword:
Protein Synthesis and Degradation
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544843/ https://doi.org/10.1074/jbc.RA118.006856 http://www.ncbi.nlm.nih.gov/pubmed/30992367
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Environmental Degradation and Language Instability
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In: Voices in Dangerous Times: Language Endangerment & Political Instability, March 22, 2019. Washington, DC (2019)
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Transparent free relatives with "who": Support for a unified analysis
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In: Proceedings of the Linguistic Society of America; Vol 4 (2019): Proceedings of the Linguistic Society of America; 40:1–6 ; 2473-8689 (2019)
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