1 |
The puzzling nuanced status of who free relative clauses in English: a follow-up to Patterson and Caponigro (2015)
|
|
|
|
In: ENGLISH LANGUAGE & LINGUISTICS, vol 26, iss 1 (2022)
|
|
BASE
|
|
Show details
|
|
5 |
Preview benefits and preview costs during reading: Exploring the interplay between display change awareness and parafoveal visual degradation (VISDEG2 project)) ...
|
|
|
|
BASE
|
|
Show details
|
|
9 |
Spectral Degradation Influences Phonological Memory in Typically Hearing Adults
|
|
|
|
In: Communication Disorders Faculty Publications (2021)
|
|
BASE
|
|
Show details
|
|
10 |
SOCIO-CULTURAL TRANSFORMATION IN POST-SOVIET UKRAINE ; СОЦИОКУЛЬТУРНАЯ ТРАНСФОРМАЦИЯ В ПОСТСОВЕТСКОЙ УКРАИНЕ ; СОЦІОКУЛЬТУРНА ТРАНСФОРМАЦІЯ В ПОСТРАДЯНСЬКІЙ УКРАЇНІ
|
|
|
|
In: Skhid; No. 1(2) (2021): PHILOSOPHICAL SCIENCES; 43-51 ; Схид; № 1(2) (2021): ФИЛОСОФСКИЕ НАУКИ; 43-51 ; Схід; № 1(2) (2021): ФІЛОСОФСЬКІ НАУКИ; 43-51 ; 2411-3093 ; 1728-9343 ; 10.21847/1728-9343.2021.1(2) (2021)
|
|
BASE
|
|
Show details
|
|
11 |
Benchmark for the evaluation of named entity recognition over ancient documents ...
|
|
|
|
BASE
|
|
Show details
|
|
12 |
Benchmark for the evaluation of named entity recognition over ancient documents ...
|
|
|
|
BASE
|
|
Show details
|
|
13 |
Mapping of soil degradation and vulnerability in the Noun Syed watershed by water erosion: what impacts of climate change approach by remote sensing and GIS ...
|
|
AOURAGH, Mbark. - : Environmental and Water Sciences, public Health and Territorial Intelligence Journal, 2020
|
|
BASE
|
|
Show details
|
|
14 |
A Review on Alkali-Silica Reaction Evolution in Recycled Aggregate Concrete
|
|
|
|
In: Materials ; Volume 13 ; Issue 11 (2020)
|
|
BASE
|
|
Show details
|
|
15 |
Soil organic carbon stocks and trends (1984-2019) predicted at 30m spatial resolution for topsoil in natural areas of South Africa ...
|
|
|
|
BASE
|
|
Show details
|
|
16 |
Soil organic carbon stocks and trends (1984-2019) predicted at 30m spatial resolution for topsoil in natural areas of South Africa ...
|
|
|
|
BASE
|
|
Show details
|
|
17 |
High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation
|
|
|
|
In: J Biol Chem (2019)
|
|
Abstract:
Repeat-associated non-AUG (RAN) translation is a noncanonical translation initiation event that occurs at nucleotide-repeat expansion mutations that are associated with several neurodegenerative diseases, including fragile X–associated tremor ataxia syndrome (FXTAS), ALS, and frontotemporal dementia (FTD). Translation of expanded repeats produces toxic proteins that accumulate in human brains and contribute to disease pathogenesis. Consequently, RAN translation constitutes a potentially important therapeutic target for managing multiple neurodegenerative disorders. Here, we adapted a previously developed RAN translation assay to a high-throughput format to screen 3,253 bioactive compounds for inhibition of RAN translation of expanded CGG repeats associated with FXTAS. We identified five diverse small molecules that dose-dependently inhibited CGG RAN translation, while relatively sparing canonical translation. All five compounds also inhibited RAN translation of expanded GGGGCC repeats associated with ALS and FTD. Using CD and native gel analyses, we found evidence that three of these compounds, BIX01294, CP-31398, and propidium iodide, bind directly to the repeat RNAs. These findings provide proof-of-principle supporting the development of selective small-molecule RAN translation inhibitors that act across multiple disease-causing repeats.
|
|
Keyword:
Protein Synthesis and Degradation
|
|
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901296/ https://doi.org/10.1074/jbc.RA119.009951 http://www.ncbi.nlm.nih.gov/pubmed/31649034
|
|
BASE
|
|
Hide details
|
|
18 |
Polyadenylate-binding protein–interacting proteins PAIP1 and PAIP2 affect translation termination
|
|
|
|
In: J Biol Chem (2019)
|
|
BASE
|
|
Show details
|
|
19 |
Environmental Degradation and Language Instability
|
|
|
|
In: Voices in Dangerous Times: Language Endangerment & Political Instability, March 22, 2019. Washington, DC (2019)
|
|
BASE
|
|
Show details
|
|
20 |
Transparent free relatives with "who": Support for a unified analysis
|
|
|
|
In: Proceedings of the Linguistic Society of America; Vol 4 (2019): Proceedings of the Linguistic Society of America; 40:1–6 ; 2473-8689 (2019)
|
|
BASE
|
|
Show details
|
|
|
|