21 |
Common mental disorders and patient-reported swallowing disorders following total laryngectomy
|
|
|
|
In: Revista CEFAC, Vol 23, Iss 6 (2021) (2021)
|
|
BASE
|
|
Show details
|
|
22 |
Expressive language development in adolescents with Down syndrome and fragile X syndrome: change over time and the role of family-related factors.
|
|
|
|
In: Journal of neurodevelopmental disorders, vol 12, iss 1 (2020)
|
|
BASE
|
|
Show details
|
|
23 |
Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
|
|
Shdo, Suzanne M; Ranasinghe, Kamalini G; Sturm, Virginia E; Possin, Katherine L; Bettcher, Brianne M; Stephens, Melanie L; Foley, Jessica M; You, Shou-Chin Christine; Rosen, Howard J; Miller, Bruce L; Kramer, Joel H; Rankin, Katherine P. - : eScholarship, University of California, 2020
|
|
Abstract:
Background: During early stages, patients with neurodegenerative diseases (NDG) often present with depressive symptoms. However, because depression is a heterogeneous disorder, more precise delineation of the specific depressive symptom profiles that arise early in distinct NDG syndromes is necessary to enhance patient diagnosis and care. Methods and Findings: Five-hundred and sixty four participants self-reported their depressive symptoms using the Geriatric Depression Scale (GDS), including 111 healthy older control subjects (NC) and 453 patients diagnosed with one of six NDGs who were at the mild stage of disease (CDR® Dementia Staging Instrument ≤ 1) [186 Alzheimer's disease (AD), 76 behavioral variant frontotemporal dementia (bvFTD), 52 semantic variant primary progressive aphasia (svPPA), 46 non-fluent variant PPA (nfvPPA), 49 progressive supranuclear palsy syndrome (PSPS), 44 corticobasal syndrome (CBS)]. The GDS was divided into subscales based on a previously published factor analysis, representing five symptoms (dysphoria, hopelessness, withdrawal, worry, and cognitive concerns). Mixed models were created to examine differences in depression subscale by group, and logistic regression analyses were performed to determine if patterns of depressive symptoms could predict a patient's NDG syndrome. PSPS patients presented with a hopeless, dysphoric, and withdrawn pattern, while patients with CBS presented with a similar but less severe pattern. Worry was a key symptom in the profile of patients with svPPA, while ADs only had abnormally elevated cognitive concerns. Depressive profile accurately predicted NDG diagnosis at a rate of between 70 and 84% accuracy. Conclusions: These results suggest that attention to specific depressive symptom profile can improve diagnostic sensitivity and can be used to provide more individualized patient care.
|
|
Keyword:
2.1 Biological and endogenous factors; 7.3 Management and decision making; Acquired Cognitive Impairment; Aging; Alzheimer's; Alzheimer's Disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Behavioral and Social Science; Brain Disorders; Clinical Research; Clinical Sciences; Dementia; depression; dysphora; frontotemporal dementia; Frontotemporal Dementia (FTD); hopelessness; Mental Health; Neurodegenerative; neurodegenerative disease; Neurological; Neurosciences; progressive supranuclear palsy; Psychology; Rare Diseases; worry
|
|
URL: https://escholarship.org/uc/item/7d043256
|
|
BASE
|
|
Hide details
|
|
24 |
Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
|
|
|
|
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
|
|
BASE
|
|
Show details
|
|
25 |
Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
|
|
|
|
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
|
|
BASE
|
|
Show details
|
|
26 |
Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
|
|
|
|
BASE
|
|
Show details
|
|
27 |
Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
|
|
|
|
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
|
|
BASE
|
|
Show details
|
|
28 |
Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
|
|
|
|
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
|
|
BASE
|
|
Show details
|
|
29 |
A neurophysiological model of speech production deficits in fragile X syndrome.
|
|
|
|
In: Brain communications, vol 2, iss 1 (2020)
|
|
BASE
|
|
Show details
|
|
30 |
Screen time in 36-month-olds at increased likelihood for ASD and ADHD.
|
|
|
|
BASE
|
|
Show details
|
|
31 |
Screen time in 36-month-olds at increased likelihood for ASD and ADHD.
|
|
|
|
BASE
|
|
Show details
|
|
32 |
Molecular Biomarkers Predictive of Sertraline Treatment Response in Young Children With Autism Spectrum Disorder.
|
|
|
|
BASE
|
|
Show details
|
|
33 |
A Therapeutic Relational Agent for Reducing Problematic Substance Use (Woebot): Development and Usability Study (Preprint)
|
|
|
|
BASE
|
|
Show details
|
|
34 |
The Relationship between Expressive Language Sampling and Clinical Measures in Fragile X Syndrome and Typical Development.
|
|
|
|
In: Brain sciences, vol 10, iss 2 (2020)
|
|
BASE
|
|
Show details
|
|
35 |
Artificial intelligence approaches to predicting and detecting cognitive decline in older adults: A conceptual review.
|
|
|
|
BASE
|
|
Show details
|
|
36 |
Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.
|
|
|
|
In: Molecular psychiatry, vol 25, iss 10 (2020)
|
|
BASE
|
|
Show details
|
|
37 |
Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.
|
|
|
|
In: Molecular psychiatry, vol 25, iss 10 (2020)
|
|
BASE
|
|
Show details
|
|
38 |
Health comorbidities and cognitive abilities across the lifespan in Down syndrome. ...
|
|
|
|
BASE
|
|
Show details
|
|
39 |
Клинико-лингвистические характеристики психических нарушений при ВИЧ-инфицировании ... : Clinical and linguistic characteristics of mental disorders in HIV infection ...
|
|
|
|
BASE
|
|
Show details
|
|
40 |
Assessing Health Related Quality of Life, Language Impairment, and Psychosocial Factors in Post-Stroke Aphasia
|
|
|
|
In: Honors College (2020)
|
|
BASE
|
|
Show details
|
|
|
|