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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 16 of 16 1 Huli of Papua : A cognatic descent system Glasse, Robert M. [Verfasser]; Barnes, J. A. [Herausgeber]. - Berlin/Boston : De Gruyter, 2018 DNB Subject Category Language Show details 2 Cytisine versus varenicline for smoking cessation in Māori (the indigenous people of New Zealand) and their extended family: Study protocol for a randomised, non-inferiority trial Walker, N; Smith, B; Barnes, J. - : Wiley, 2018 BASE Show details 3 Utilising Openair to support multi-stakeholder engagement and the resolution of air quality issues Hayes, E. T.; Chatterton, T.; Barnes, J.. - : National Association for Clean Air, 2013 BASE Show details 4 The health and development of children born to older mothers in the United Kingdom: observational study using longitudinal cohort data. Sutcliffe, AG; Barnes, J; Belsky, J... In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2012) BASE Show details 5 The health and development of children born to older mothers in the United Kingdom: observational study using longitudinal cohort data Sutcliffe, AG; Barnes, J; Belsky, J... In: British Medical Journal , 345 , Article e5116. (2012) (2012) BASE Show details 6 Basic Visual Function and Cortical Thickness Patterns in Posterior Cortical Atrophy Lehmann, M; Barnes, J; Ridgway, GR... In: CEREB CORTEX , 21 (9) 2122 - 2132. (2011) (2011) BASE Show details 7 Effects of early child-care on cognition, language, and task-related behaviours at 18 months: an English study. Sylva, K; Stein, A; Leach, P... In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2011) BASE Show details 8 Reduced Cortical Thickness in the Posterior Cingulate Gyrus is Characteristic of Both Typical and Atypical Alzheimer's Disease Lehmann, M; Rohrer, JD; Clarkson, MJ... In: J ALZHEIMERS DIS , 20 (2) 587 - 598. (2010) (2010) BASE Show details 9 Cheminformatics Analysis of Assertions Mined from Literature that Describe Drug-Induced Liver Injury in Different Species Fourches, D.; Barnes, J. C.; Day, N. C.; Bradley, P.; Reed, J.Z.; Tropsha, A.. - 2010 Abstract: Drug Induced Liver Injury (DILI) is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structure is critical to help guiding experimental drug discovery projects towards safer medicines. In this study, we have compiled a dataset of 951 compounds reported to produce a wide range of effects in the liver in different species, comprising humans, rodents, and non-rodents. The liver effects for this dataset were obtained as assertional meta-data, generated from MEDLINE abstracts using a unique combination of lexical and linguistic methods and ontological rules. We have analyzed this dataset using conventional cheminformatics approaches and addressed several questions pertaining to cross-species concordance of liver effects, chemical determinants of liver effects in humans, and the prediction of whether a given compound is likely to cause a liver effect in humans. We found that the concordance of liver effects was relatively low (ca. 39–44%) between different species raising the possibility that species specificity could depend on specific features of chemical structure. Compounds were clustered by their chemical similarity, and similar compounds were examined for the expected similarity of their species-dependent liver effect profiles. In most cases, similar profiles were observed for members of the same cluster, but some compounds appeared as outliers. The outliers were the subject of focused assertion re-generation from MEDLINE, as well as other data sources. In some cases, additional biological assertions were identified which were in line with expectations based on compounds' chemical similarity. The assertions were further converted to binary annotations of underlying chemicals (i.e., liver effect vs. no liver effect), and binary QSAR models were generated to predict whether a compound would be expected to produce liver effects in humans. Despite the apparent heterogeneity of data, models have shown good predictive power assessed by external five-fold cross validation procedures. The external predictive power of binary QSAR models was further confirmed by their application to compounds that were retrieved or studied after the model was developed. To the best of our knowledge, this is the first study for chemical toxicity prediction that applied QSAR modeling and other cheminformatics techniques to observational data generated by the means of automated text mining with limited manual curation, opening up new opportunities for generating and modeling chemical toxicology data. Keyword: Article URL: http://www.ncbi.nlm.nih.gov/pubmed/20014752 https://doi.org/10.1021/tx900326k http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850112 BASE Hide details 10 Tracking progression in frontotemporal lobar degeneration Serial MRI in semantic dementia Rohrer, JD; McNaught, E; Foster, J... In: NEUROLOGY , 71 (18) 1445 - 1451. (2008) (2008) BASE Show details 11 Mapping the progression of progranulin-associated frontotemporal lobar degeneration Rohrer, JD; Warren, JD; Barnes, J... In: NAT CLIN PRACT NEURO , 4 (8) 455 - 460. (2008) (2008) BASE Show details 12 Effects of fully-established Sure Start Local Programmes on 3-year-old children and their families living in England: a quasi-experimental observational study Melhuish, E.; Belsky, J.; Leyland, A.H.. - 2008 BASE Show details 13 Effects of fully-established Sure Start Local Programmes on 3-year-old children and their families living in England: a quasi-experimental observational study. Melhuish, E; Belsky, J; Leyland, AH... In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2008) BASE Show details 14 The influence of maternal depression, caregiving, and socioeconomic status in the post-natal year on children's language development. Leach, P; Barnes, J; Malmberg, LE... In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2008) BASE Show details 15 Effects of Sure Start local programmes on children and families: early findings from a quasi-experimental, cross sectional study. Belsky, J; Melhuish, E; Barnes, J... In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2006) BASE Show details 16 The other side of the ecotourism coin: consumptive tourism in Southern Africa Novelli, Marina; Barnes, J.; Humavindu, M.. - 2006 BASE Show details

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