2 |
Cytisine versus varenicline for smoking cessation in Māori (the indigenous people of New Zealand) and their extended family: Study protocol for a randomised, non-inferiority trial
|
|
|
|
BASE
|
|
Show details
|
|
3 |
Utilising Openair to support multi-stakeholder engagement and the resolution of air quality issues
|
|
|
|
BASE
|
|
Show details
|
|
4 |
The health and development of children born to older mothers in the United Kingdom: observational study using longitudinal cohort data.
|
|
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2012)
|
|
BASE
|
|
Show details
|
|
5 |
The health and development of children born to older mothers in the United Kingdom: observational study using longitudinal cohort data
|
|
|
|
In: British Medical Journal , 345 , Article e5116. (2012) (2012)
|
|
BASE
|
|
Show details
|
|
6 |
Basic Visual Function and Cortical Thickness Patterns in Posterior Cortical Atrophy
|
|
|
|
In: CEREB CORTEX , 21 (9) 2122 - 2132. (2011) (2011)
|
|
BASE
|
|
Show details
|
|
7 |
Effects of early child-care on cognition, language, and task-related behaviours at 18 months: an English study.
|
|
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2011)
|
|
BASE
|
|
Show details
|
|
8 |
Reduced Cortical Thickness in the Posterior Cingulate Gyrus is Characteristic of Both Typical and Atypical Alzheimer's Disease
|
|
|
|
In: J ALZHEIMERS DIS , 20 (2) 587 - 598. (2010) (2010)
|
|
BASE
|
|
Show details
|
|
9 |
Cheminformatics Analysis of Assertions Mined from Literature that Describe Drug-Induced Liver Injury in Different Species
|
|
|
|
BASE
|
|
Show details
|
|
10 |
Tracking progression in frontotemporal lobar degeneration Serial MRI in semantic dementia
|
|
Rohrer, JD; McNaught, E; Foster, J; Clegg, SL; Barnes, J; Omar, R; Warrington, EK; Rossor, MN; Warren, JD; Fox, NC
|
|
In: NEUROLOGY , 71 (18) 1445 - 1451. (2008) (2008)
|
|
Abstract:
Background: Semantic dementia is a sporadic neurodegenerative disorder characterized by the progressive erosion of semantic processing and is one of the canonical subtypes of frontotemporal lobar degeneration. This study aimed to characterize the pattern of global and regional longitudinal brain atrophy in semantic dementia and to identify imaging biomarkers that could underpin therapeutic trials.Methods: Twenty-one patients with semantic dementia (including eight pathologically confirmed cases) underwent whole-brain and region-of-interest analyses on volumetric brain MRI scans at two time points. Sample size estimates for trials were subsequently calculated using these data.Results: Mean (SD) whole-brain atrophy rate was 39.6 (31.9) mL/y [3.2 (12.0) mL/y in controls], with ventricular enlargement of 8.9 (4.4) mL/y [1.0 (1.0) mL/y in controls]. All patients had a smaller left temporal lobe at baseline [left mean 31.9 (6.9) mL, right mean 49.2 (9.5) mL; p < 0.0001]; however, the mean rate of atrophy was significantly greater in the right temporal lobe [right 3.9 (1.7) mL/y, left 2.8 (1.2) mL/y; p = 0.02]. Similarly, whereas the left hippocampus was smaller at baseline, the mean atrophy rate was significantly greater in the right hippocampus. Using the atrophy rates generated, sample size requirements for clinical trials were found to be smallest for temporal lobe measurement.Conclusions: These findings show that the rate of tissue loss in the right temporal lobe overtakes the left temporal lobe as semantic dementia evolves, consistent with the later development of symptoms attributable to right temporal lobe dysfunction. Furthermore, our findings demonstrate that MRI measures of temporal lobe volume loss could provide a feasible and sensitive index of disease progression in semantic dementia. Neurology (R) 2008; 71: 1445-1451
|
|
Keyword:
ALZHEIMERS-DISEASE; APHASIA; ATROPHY; BRAIN; CEREBRAL VOLUME; CONSENSUS; CRITERIA; IMPAIRMENT; PATTERNS
|
|
URL: http://discovery.ucl.ac.uk/105401/
|
|
BASE
|
|
Hide details
|
|
11 |
Mapping the progression of progranulin-associated frontotemporal lobar degeneration
|
|
|
|
In: NAT CLIN PRACT NEURO , 4 (8) 455 - 460. (2008) (2008)
|
|
BASE
|
|
Show details
|
|
12 |
Effects of fully-established Sure Start Local Programmes on 3-year-old children and their families living in England: a quasi-experimental observational study
|
|
|
|
BASE
|
|
Show details
|
|
13 |
Effects of fully-established Sure Start Local Programmes on 3-year-old children and their families living in England: a quasi-experimental observational study.
|
|
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2008)
|
|
BASE
|
|
Show details
|
|
14 |
The influence of maternal depression, caregiving, and socioeconomic status in the post-natal year on children's language development.
|
|
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2008)
|
|
BASE
|
|
Show details
|
|
15 |
Effects of Sure Start local programmes on children and families: early findings from a quasi-experimental, cross sectional study.
|
|
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2006)
|
|
BASE
|
|
Show details
|
|
16 |
The other side of the ecotourism coin: consumptive tourism in Southern Africa
|
|
|
|
BASE
|
|
Show details
|
|
|
|