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Syntactic and Semantic Specialization and Integration in 5- to 6-Year-Old Children during Auditory Sentence Processing
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Family-based genetic investigation of SLI (Andres et al., 2020) ...
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Family-based genetic investigation of SLI (Andres et al., 2020) ...
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2019 ASHA Research Symposium: Mabel L. Rice, Panel Discussion on Specific Language Impairment ...
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2019 ASHA Research Symposium: Mabel L. Rice, What Studies of Twins Tell Us About Specific Language Impairment in Children: Twinning Effects & Heritability at 2, 4, 6, and 16 Years of Age ...
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2019 ASHA Research Symposium: Mabel L. Rice, Panel Discussion on Specific Language Impairment ...
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2019 ASHA Research Symposium: Mabel L. Rice, Panel Discussion on Specific Language Impairment ...
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2019 ASHA Research Symposium: Mabel L. Rice, What Studies of Twins Tell Us About Specific Language Impairment in Children: Twinning Effects & Heritability at 2, 4, 6, and 16 Years of Age ...
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2019 ASHA Research Symposium: Mabel L. Rice, What Studies of Twins Tell Us About Specific Language Impairment in Children: Twinning Effects & Heritability at 2, 4, 6, and 16 Years of Age ...
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Causal Pathways for Specific Language Impairment: Lessons From Studies of Twins
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In: J Speech Lang Hear Res (2020)
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Pedigree-Based Gene Mapping Supports Previous Loci and Reveals Novel Suggestive Loci in Specific Language Impairment
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In: J Speech Lang Hear Res (2020)
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Advances in Specific Language Impairment Research and Intervention: An Overview of Five Research Symposium Papers
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In: J Speech Lang Hear Res (2020)
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Heritability of Specific Language Impairment and Nonspecific Language Impairment at Ages 4 and 6 Years Across Phenotypes of Speech, Language, and Nonverbal Cognition
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In: J Speech Lang Hear Res (2020)
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Birth Prevalence of Congenital Cytomegalovirus Infection in HIV-Exposed Uninfected Children in the Era of Combination Antiretroviral Therapy
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In: J Pediatr (2019)
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Prenatal and perinatal risks for late language emergence in a population-level sample of twins at age 2
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Grammar Clinical Marker Yields Substantial Heritability for Language Impairments in 16-Year-Old Twins
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Risk for Speech and Language Impairments in Pre-school Aged HIV-Exposed Uninfected Children with in utero Combination Antiretroviral Exposure
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Mapping Chromosomal Loci in Specific Language Impairment: A Pedigree-Focused Approach
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Abstract:
Specific language impairment (SLI) is characterized by a delay in the mastery of language despite average or above average nonverbal intelligence (IQ). There are multiple assessments used in practice to measure the language abilities of individuals with SLI. Standardized language assessments in conjunction with a measure of nonverbal IQ are the most crucial for distinguishing individuals with and without SLI in research practice. Studies have found that the incidence of SLI in extended relatives of probands is significantly higher than population matched relatives of controls. The heritability estimates of SLI are higher in MZ twins than DZ twins. Both family and twin studies indicate genetic involvement in the transmission of SLI. Previous genetic studies in SLI have found candidate chromosomal loci on 2q24, 6p21, 10q26, 12p13, 21q, and several candidate genes including TM4SF20, NFXL1, CNTNAP2, KIAA0319, CMIP, and ATP2C2 have been implicated in SLI. However, the causes of SLI are not well understood and investigation may benefit from family-based approaches. The current study approached genetic investigation of SLI one pedigree at a time. We report SLI loci on chromosomes 4q, 3p, 6q, 9q, 10q, 12p, 14q and 15q linked with the omnibus standard score categorical phenotype, indicating genetic and phenotypic heterogeneity of SLI. These findings support the discussion of previous hypotheses that SLI is a polygenic disorder, with multiple loci reported in a few of the families included in this report.
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Keyword:
genetic linkage; Genetics; Language; language phenotypes; linkage analysis; pedigree; reading phenotypes; specific language impairment
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URL: http://hdl.handle.net/1808/27806 http://dissertations.umi.com/ku:15883
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Effects of Language Context on Ratings of Shy and Unsociable Behaviors in English Language Learning Children
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