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1
Digital Speech Analysis in Progressive Supranuclear Palsy and Corticobasal Syndromes
In: J Alzheimers Dis (2021)
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2
Automated analysis of lexical features in Frontotemporal Degeneration
In: Cortex (2021)
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3
Automated analysis of natural speech in amyotrophic lateral sclerosis spectrum disorders
In: Neurology (2020)
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4
Automated analysis of lexical features in Frontotemporal Degeneration
In: medRxiv (2020)
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5
A Longitudinal Study of Speech Production in Primary Progressive Aphasia and Behavioral Variant Frontotemporal Dementia
In: Brain Lang (2019)
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6
Linguistic markers in Parkinson’s disease (Smith et al., 2018) ...
Smith, Kara M.; Ash, Sharon; Xie, Sharon X.. - : Figshare, 2018
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7
Linguistic markers in Parkinson’s disease (Smith et al., 2018) ...
Smith, Kara M.; Ash, Sharon; Xie, Sharon X.. - : ASHA journals, 2018
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8
Validated automatic speech biomarkers in primary progressive aphasia
Nevler, Naomi; Ash, Sharon; Irwin, David J. - : John Wiley and Sons Inc., 2018
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9
Longitudinal Changes in Semantic Concreteness in Semantic Variant Primary Progressive Aphasia (svPPA)
Abstract: This study examines longitudinal changes in the concreteness of nouns produced by human patients with semantic variant primary progressive aphasia (svPPA). Cross-sectional studies show that patients with svPPA demonstrate severe loss of concrete noun knowledge linked to atrophy of the left ventral temporal lobe. It is unknown how disease spread and duration affect the magnitude of the concreteness impairment in svPPA. We evaluate longitudinal spoken production of concrete nouns in svPPA, and relate this to changes in longitudinal MRI measures of gray matter (GM). Noun concreteness in svPPA is compared to that of behavioral variant frontotemporal dementia (bvFTD) patients, who typically demonstrate highly concrete speech. We elicited naturalistic speech samples at two time points (time 1 and time 2) in patients with svPPA (n = 11) and bvFTD (n = 15) through descriptions of the Cookie Theft picture and evaluated each spoken noun for concreteness. Compared to bvFTD patients whose noun production remained highly concrete throughout the testing period, mixed-effects models revealed that noun concreteness significantly decreased as disease progressed in svPPA. We also measured longitudinal changes to GM in a subset of svPPA patients (n = 7), who showed significant decline in the left and right temporal and frontal regions. Regression analyses revealed that longitudinal GM atrophy in the right fusiform and parahippocampal gyri and the left superior temporal gyrus was related to decreasing noun concreteness. These results suggest that progressive atrophy of the ventral temporal lobe in svPPA contributes to declining concrete noun production over time.
Keyword: New Research
URL: https://doi.org/10.1523/ENEURO.0197-18.2018
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377408/
http://www.ncbi.nlm.nih.gov/pubmed/30783611
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10
Evaluation of Linguistic Markers of Word-Finding Difficulty and Cognition in Parkinson's Disease
Smith, Kara M.; Ash, Sharon; Xie, Sharon X.. - : American Speech-Language-Hearing Association, 2018
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11
Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia
Giannini, Lucia A.A.; Irwin, David J.; McMillan, Corey T.. - : Lippincott Williams & Wilkins, 2017
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12
Longitudinal decline in speech production in Parkinson's disease spectrum disorders
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13
Transcranial direct current stimulation for the treatment of primary progressive aphasia: An open-label pilot study
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14
Dissociation of Quantifiers and Object Nouns in Speech in Focal Neurodegenerative Disease
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15
Dissociable substrates underlie the production of abstract and concrete nouns
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16
Why study connected speech production?
In: Cognitive neuroscience of natural language use (Cambridge, 2015), p. 29-58
MPI für Psycholinguistik
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17
Why study connected speech production?
In: Cognitive neuroscience of natural language use (Cambridge, 2015), p. 29-58
MPI für Psycholinguistik
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18
Deficits in sentence expression in amyotrophic lateral sclerosis
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19
Differentiating primary progressive aphasias in a brief sample of connected speech
Ash, Sharon; Evans, Emily; O'Shea, Jessica. - : Lippincott Williams & Wilkins, 2013
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20
Grammatical comprehension deficits in non-fluent/agrammatic primary progressive aphasia
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